B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance

Journal of Immunology

Volumn 163, Issue 4, 1999, Pages 2284-2290

  Liu, Liming ^a   Kuchroo, Vijay K ^a   Weiner, Howard L ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 2; MONOCLONAL ANTIBODY; MYELIN BASIC PROTEIN; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HELPER CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; BINDING SITES, ANTIBODY; CLONAL ANERGY; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNE TOLERANCE; INJECTIONS, INTRAPERITONEAL; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MYCOBACTERIUM TUBERCULOSIS; MYELIN BASIC PROTEINS; OVALBUMIN;

EID: 0033567051     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Friedman, A., and H. Weiner. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA 91:6688.
2. Chen, Y., V. K. Kuchroo, J.-I. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T-cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
3. Chen, Y., J. Inobe, R. Marks, P. Gonnella, V. K. Kuchroo, and H. L. Weiner. 1995. Peripheral deletion of antigen-reactive T-cells in oral tolerance. Nature 376:177.
4. Chen, Y., J.-i. Inobe, and H. L. Weiner. 1997. Inductive events in oral tolerance in the TCR transgenic adoptive transfer model. Cell. Immunol. 178:62.
5. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, K.-Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
6. Lenschow D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
7. Diebler, G. E., R. E. Martenson, and M. W. Kies. 1972. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep. Biochem. 2:139.
8. Neurath, M. F., I. Fuss, B. L. Kelsall, D. H. Presky, W. Waegell, and W. Strober. 1996. Experimental granulomalous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J. Exp. Med. 183:2605.
9. Miller, A., O. Lider, A. B. Roberts, M. B. Sporn, and H. L. Weiner. 1992. Suppressor T-cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of TGF-β following antigen specific triggering. Proc. Natl. Acad. Sci. USA 89:421.
10. Kuchroo, V., M. Prabhu Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules differentially activate the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
11. Whitacre, C. C., I. E. Gienapp, C. G. Orosz, and D. Bitar. 1991. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. J. Immunol. 147:2155.
12. Perez, V. L., L. V. Parijs, A. Biuckians, X. X. Zheng, T. B. Strom, and A. K. Abbas. 1997. Induction of peripheral T-cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411.
13. Samoilova, E. B., J. L. Horton, H. Zhang, S. J. Khoury, H. L. Weiner, and Y. Chen. 1998. CTLA4 is required for the induction of high dose oral tolerance. Int. Immunol. 10:491.
14. Borriello, F., M. P. Sethna, S. D. Boyd, A. N. Schweitzer, E. A. Tivol, D. Jacoby, T. B. Strom, E. M. S. Simpson, G. J. Freeman, and A. H. Sharpe. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6:303.
15. Lenschow, D., K. Herold, L. Ree, B. Patel, A. Koons, B. Singh, C. Thompson, and J. Bluestone. 1996. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 5:285.
16. Nuriya, S., H. Yagita, K. Okumura, and M. Azuma. 1996. The differential role of CD86 and CD80 co-stimulatory molecules in the induction and the effector phases of contact hypersensitivity. Int. Immunol. 8:917.
17. Miller, S. D., C. L. Vanderlugt, D. J. Lenschow, J. G. Pope, N. J. Karandikar, M. C. D. Canto, and J. A. Bluestone. 1995. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3:739.
18. Lenschow, D. J., A. I. Sperling, M. P. Cooke, G. Freeman, L. Rhee, D. C. Decker, G. Gray, L. M. Nadler, C. C. Goodnow, and J. A. Bluestone. 1994. Differential upregulation of the B7-1 and B7-2 costimulatory molecules following immunoglobulin receptor engagement by antigen. J. Immunol. 153:1990.
19. Inaba, K., M. Witmer-Pack, M. Inaba, K. S. Hathcock, H. Sakuta, M. Azuma, H. Yagita, K. Okumura, P. S. Linsley, S. Ikehara, et al. 1994. The tissue distribution of the B7-2 costimulation in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180:1849.
20. Inobe, J., A. J. Slavin, Y. Komagata, Y. Chen, L. Liu, and H. L. Weiner. 1998. IL-4 is a differentiation factor for transforming growth factor-β-secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur. J. Immunol. 28:2780.
21. + T cells: IL-4 and IFN-γ have opposing effects, while TGF-β positively regulates its own production. J. Immunol. 160:5719.
22. Cong, Y., C. T. Weaver, and C. O. Elson. 1997. The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective upregulation of B7.2 expression. J. Immunol. 159:5301.
23. Kweon, M. N., K. Fujihashi, Y. Wakatsuki, T. Koga, M. Yamamoto, J. R. McGhee, and H. Kiyono. 1999. Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions. J. Immunol. 162:1904.