Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: Involvement of mitogen-activated protein kinase and Fas pathways

Cancer Research

Volumn 61, Issue 20, 2001, Pages 7479-7487

  Ghose, Aurnab ^a   Fleming, Janis ^a   El Bayoumy, Karam ^b   Harrison, Paul R ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; SELENITE; SELENIUM;

APOPTOSIS; ARTICLE; CANCER RISK; CELL GROWTH; CHEMICAL CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DELETION MUTANT; HUMAN; HUMAN CELL; MOUTH CARCINOMA; MOUTH MUCOSA; PRIORITY JOURNAL; RESPIRATORY TRACT CANCER; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; ENZYME INDUCTION; FAS LIGAND PROTEIN; GLUTATHIONE; GROWTH INHIBITORS; HELA CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOUTH MUCOSA; MOUTH NEOPLASMS; ORGANOSELENIUM COMPOUNDS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 0035886849     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. Chemopreventive agents: Selenium
2. Prospective study of serum selenium levels and incident esophageal and gastric cancers
3. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin
4. Decreased incidence of prostate cancer with selenium supplementation: Results of a double-blind cancer prevention trial
5. Lessons from basic research in selenium and cancer prevention
6. Selenium, the element of the moon, in life on earth
7. In vitro and in vivo studies of methylseleninic acid: Evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention
8. Chemoprevention of colon carcinogenesis by the synthetic organoselenium compound, 1, 4-phenylenebis(methylene)selenocyanate
9. Chemoprevention of colon carcinogenesis by the synthetic organoselenium compound 1, 4-phenylenebis(methylene)selenocyanate
10. Inhibition of 4-(methylnitrosamino)-I-(3-pyridyl)-I-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1, 4-phenylenebis(methylene)selenocyanate
11. Chemopreventive and growth inhibitory, effects of selenium
12. Selenium and signal transduction: Roads to cell death and anti-tumor activity
13. Responsiveness of selenoproteins to dietary selenium
14. Tissue-specific regulation of selnoenzyme gene expression during selenium deficiency in rats
15. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
16. Cellular glutathione peroxidase knockout mice express normal levels of selenium-dependent plasma and phospholipid hydroperoxide glutathione peroxidases in various tissues
17. Mice with a homozygous null mutation for the most abundant gluthione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
18. Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase
19. Selenium metabolism, selenoproteins and mechansims of cancer prevention: Complexities with thioredoxin reductase
20. Effect of methylated forms of selenium on cell viability and the induction of DNA strand breakage
21. The selenium metabolite selenodiglutathione induces p53 and apoptosis: Relevance to the chemopreventive effects of selenium
22. Comparison of the effects of an organic and inorganic form of selenium on a mammary carcinoma cell line
23. Effects of organic and inorganic selenium compounds on rat mammary tumor cells
24. Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells
25. Differential induction of growth arrest inducible genes by selenium compounds
26. Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronised mouse mammary, epithelial tumor cells
27. Inappropriate retinoic acid receptor-β expression in oral dysplasias: Correlation with acquisition with the immortal phenotype
28. Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss
29. Reduction of the selenotrisulphide derivative of glutathione to a persulfide analog by glutathione reductase
30. Inhibition of 7, 12-dimethylbenz(a)anthracene-induced tumors and DNA adduct formation in the mammary glands of female Spague-Dawley rats by the synthetic organoselenium compound, 1, 4-phenylenebis(methylene)selenocyanate
31. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
32. Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signalling pathways while having opposite effects on myeloid cell survival
33. Molecular mechanisms of cancer prevention by selenium compounds
34. Expression of the functional soluble form of human Fas ligand in activated lymphocytes
35. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
36. The search for physiological substrates of MAP and SAP kinases in mammalian cells
37. P13K: Downstream AKTion blocks apoptosis
38. Big mitogen activated protein kinase I (BMK1) is a redox-sensitive kinase
39. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
40. Specificity and mechanism of action of some commonly used protein kinase inhibitors
41. Role of p38 and JNK mitogens-activated protein kinases in the activation of ternary complex factors
42. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes
43. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
44. Signal transduction by the JNK group of MAP kinases
45. The biochemistry of apoptosis
46. A novel AP1 element in the CD95 ligand promoter is required for induction of apoptosis in hepacellular carcinoma cells upon treatment with anticancer drugs
47. Mechanism of action of a dominant-negative mutant of c-Jun
48. Dominant-negative PADD inhibits TNFR60-, Fas/Apo1-, and TRAIL-R/Apo2-mediated cell death but not gene induction
49. Selenium effects on prostate cell growth
50. Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apomsis of T lymphocytes
51. c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents
52. Role of CD95 (APO-1/Fas) system in chemotherapy
53. From bench to clinic with apoptosis-based therapeutic agents
54. CD95's deadly mission in the immune system
55. Selenium and immunocompetence in patients with head and neck cancer
56. Selenium in diet, blood, and toenails in relation to human health in a seleniferous area
57. 1, 4-phenylenebis (methylene)selenocyanate exerts exceptional chemopreventive activity in rat tongue carcinogenesis
58. Effects of chemopreventive selenium compounds on Jun N-kinase activities
59. Selenite inhibits the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) through a thiol redox mechanism
60. Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP or RAIDDD
61. Mitogen-activated protein kinase-mediated Fas apoptotic signalling pathway
62. Dissecting Fas signalling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation
63. Lack of a role for Jun kinase and AP1 in Fas-induced apoptosis
64. JNK activation is not required for Fas-mediated apoptosis
65. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases
66. FADD: Essential for embryo development and signalling from some. but not all, inducers of apoptosis
67. On the nature of selenium toxicity and carcinostatic activity
68. Active oxygen generation by the reaction of selenite with reduced glutathione in vitro
69. Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells
70. 2 toxicity
71. The role of the redox protein thioredoxin in cell growth and cancer
72. Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase
73. Selenite is a substrate for calf thymus thioredoxin reductase and thiomdoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen
74. Induction of apoptosis by ASKI, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
75. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK)I
76. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents