Molecular mechanisms of cancer prevention by selenium compounds

Nutrition and Cancer

Volumn 40, Issue 1, 2001, Pages 42-49

  Fleming, Janis ^a   Ghose, Aurnab ^a   Harrison, Paul R ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 PHENYLENEBIS(METHYLENE)SELENOCYANATE; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; FAS LIGAND; GLUTATHIONE PEROXIDASE; HEME OXYGENASE; MANNITOL; PYRROLIDINE DITHIOCARBAMATE; SCAVENGER; SELENIUM; SELENIUM DERIVATIVE; SELENODIGLUTATHIONE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL CULTURE; CANCER PREVENTION; CARCINOGENESIS; CELL GROWTH; CHEMOPROPHYLAXIS; DISEASE MARKER; ENZYME ACTIVATION; IMMUNE RESPONSE; IN VIVO STUDY; MOUTH CARCINOMA; MOUTH MUCOSA; NONHUMAN; OXIDATION REDUCTION REACTION; REVIEW; SIGNAL TRANSDUCTION; TUMOR BIOPSY;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DISEASE MODELS, ANIMAL; FAS LIGAND PROTEIN; GLUTATHIONE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOUTH NEOPLASMS; ORGANOSELENIUM COMPOUNDS; SELENIUM COMPOUNDS; TUMOR CELLS, CULTURED;

ANIMALIA; LETHRINIDAE;

EID: 0035679690     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S15327914NC401_9     Document Type: Review

References (90)

1. Mechanisms of selenium inhibition of tumorigenesis
2. Factors affecting the antitumorigenic properties of selenium in mice
3. Effect of inorganic and organic forms of dietary selenium on the promotional phase of mammary carcinogenesis in the rat
4. Lessons from basic research in selenium and cancer prevention
5. Chemopreventive agents: Selenium
6. Activity of methylated forms of selenium in cancer prevention
7. Chemical form of selenium, critical metabolites, and cancer prevention
8. Effects of organoselenium compounds on induction of mouse forestomach tumors by benzo[a]pyrene
9. Evaluation of organoselenium compounds for potential chemopreventive properties in colon carcinogenesis
10. Chemoprevention of experimental mammary carcinogenesis by the synthetic organoselenium compound, benzylselenocyanate, in rats
11. Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention
12. Cancer chemoprevention by aliphatic selenocyanates: Effect of chain length on inhibition of mammary tumors and DMBA adducts
13. Inhibition of 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate
14. Chemoprevention of colon carcinogenesis by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate
15. Inhibition of 7,12-dimethylbenz[a]anthracene-induced tumors and DNA adduct formation in the mammary glands of female Spague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate
16. Allium chemistry: Identification of selenoaminoacids in ordinary and selenium-enriched garlic, onion and broccoli using gas chromatography with atomic emission detection
17. Prediagnostic serum selenium and risk of cancer
18. Association between serum selenium and the risk of cancer
19. Is serum selenium a risk factor for cancer?
20. Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: Matched case-control analysis of prospective data
21. Low plasma selenium as a risk factor for cancer death in middle-aged men
22. Is serum selenium a risk factor for cancer in men only?
23. Serum selenium and risk of cancer, by specific sites: Case-control analysis of prospective data
24. Serum selenium and risk of cancer: A prospective follow-up of nine years
25. Serum levels of selenium and retinol and the subsequent risk of cancer
26. Serum selenium concentration associated with risk of cancer
27. Serum selenium and subsequent risk of cancer among Finnish men and women
28. A prospective study of toenail selenium levels and cancer among women
29. A prospective study on selenium status and the risk of lung cancer
30. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer
31. Serum β-carotene, vitamins A and E, selenium and the risk of lung cancer
32. A prospective cohort study on toenail selenium levels and risk of gastrointestinal cancer
33. Prospective study of serum selenium levels and incident esophageal and gastric cancers
34. A prospective study of selenium status and breast cancer risk
35. Toenail selenium levels and the risk of breast cancer
36. Selenium in human mammary carcinogenesis: A case-cohort study
37. A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China
38. Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence and disease-specific mortality in the general population
39. Nutrition intervention trials in Linxian, China: Multiple vitamin/mineral supplementation, cancer incidence and disease-specific mortality among adults with esophageal dysplasia
40. β-carotene supplementation and incidence of cancer and cardiovascular disease: The Women's Health Study
41. A clinical trial of antioxidant vitamins to prevent colorectal adenoma
42. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease
43. β-carotene supplementation and incidence of cancer and cardiovascular disease: The Women's Health Study
44. The association between baseline vitamin E, selenium and prostate cancer in the α-Tocopherol, β-Carotene Cancer Prevention Study
45. Prostate cancer and supplementation with α-tocopherol and β-carotene: Incidence and mortality in a controlled trial
46. The effect of vitamin E and βcarotene on the incidence of lung cancer and other cancers in male smokers
47. α-tocopherol and β-carotene supplements and lung cancer incidence in the α-Tocopherol, β-Carotene Cancer Prevention Study: Effects of base-line characteristics and study compliance
48. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease
49. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin
50. Decreased incidence of prostate cancer with selenium supplementation: Results of a double-blind cancer prevention trial
51. Response of rat selenoprotein P to selenium administration and fate of its selenium
52. Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selnium deficiency and repletion
53. Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats
54. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
55. Cellular glutathione peroxidase knockout mice express normal levels of selenium-dependent plasma and phospholipid hydroperoxide glutathione peroxidases in various tissues
56. Mice with a homozygous null mutation for the most abundant gluthione peroxidase, Gpxl, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
57. Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase
58. Selenium metabolism, selenoproteins and mechansims of cancer prevention: Complexities with thioredoxin reductase
59. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequences
60. Structure-expression relationships of the 15 kDa selenoprotein: Possible role of the protein in cancer etiology
61. In vitro and in vivo effects of sodium selenite on 7,12-dimethylbenz[a]anthracene-DNA adduct formation in isolated rat mammary epithelial cells
62. Inhibition of 7,12-dimethylbenz[a]anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic selenium compound, 1,4-phenylenebis(methylene)selenocyanate
63. Mechanism of benzylselenocyanate inhibition of azo-methane-induced colon carcinogenesis in F344 Rats
64. Effect of methylated forms of selenium on cell viability and the induction of DNA strand breakage
65. The selenium metabolite selenodiglutathione induces p53 and apoptosis: Relevance to the chemopreventive effects of selenium
66. Comparison of the effects of an organic and inorganic form of selenium on a mammary carcinoma cell line
67. Effects of organic and inorganic selenium compounds on rat mammary tumor cells
68. Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells
69. Differential induction of growth arrest inducible genes by selenium compounds
70. On the nature of selenium toxicity and carcinostatic activity
71. Active oxygen generation by the reaction of selenite with reduced glutathione in vitro
72. Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells
73. 2 toxicity
74. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide and sodium arsenite
75. The role of the redox protein thioredoxin in cell growth and cancer
76. Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: Involvement of MAP kinase and Fas pathways
77. Inappropriate retinoic acid receptor-β expression in oral dysplasias: Correlation with acquisition with the immortal phenotype
78. Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss
79. Selenium effects on prostate cell growth
80. Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apotosis of T lymphocytes
81. CD95's deadly mission in the immune system
82. Selenium and immunocompetence in patients with head and neck cancer
83. 1,4-Phenylenebis(methylene)selenocyanate exerts exceptional chemo-preventive activity in rat tongue carcinogenesis
84. Signal transduction by the JNK group of MAP kinases
85. Induction of apoptosis by ASKI, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
86. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK)1
87. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents
88. Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase
89. Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen
90. Selenium in diet, blood, and toenails in relation to human health in a seleniferous area