The glucocorticoid receptor is required for stress erythropoiesis

Genes and Development

Volumn 13, Issue 22, 1999, Pages 2996-3002

  Bauer, Anton ^a,b   Tronche, Francois ^b   Wessely, Oliver ^b,c   Kellendonk, Christoph ^b   Reichardt, Holger M ^b   Steinlein, Peter ^a   Schütz, Günther ^b   Beug, Hartmut ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Glucocorticoid receptor; Mice; Spleen; Stress erythropoiesis; Targeted mutation

Indexed keywords

GLUCOCORTICOID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; ERYTHROPOIESIS; FETUS; GENE EXPRESSION; GENE MUTATION; HEMOLYSIS; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STEM CELL; STRESS;

ANEMIA; ANIMALS; ANOXIA; CELLS, CULTURED; CHICKENS; CULTURE MEDIA, SERUM-FREE; DIMERIZATION; ERYTHROID PROGENITOR CELLS; ERYTHROPOIESIS; ERYTHROPOIETIN; HEMATOPOIESIS, EXTRAMEDULLARY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOLYSIS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; LIVER; MICE; MICE, KNOCKOUT; RADIATION CHIMERA; RECEPTORS, GLUCOCORTICOID; STEM CELL FACTOR; STRESS; TRANS-ACTIVATION (GENETICS);

EID: 0032758352     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.22.2996     Document Type: Article

References (42)

1. Axelrod, J. and T.D. Reisine. 1984. Stress hormones: Their interaction and regulation. Science 224: 452-459.
2. Bauer, A., E. Ulrich, M. Andersson, H. Beug, and M. von Lindern. 1997. Mechanism of transformation by v-ErbA: Replacement of steroid hormone receptor function in self-renewal induction. Oncogene 15: 701-715.
3. Bauer, A., W. Mikulits, G. Lagger, G. Stengl, G. Brosch, and H. Beug. 1998. The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors. EMBO J. 17: 4291-4303.
4. Beato, M., P. Herrlich, and G. Schütz. 1995. Steroid hormone receptors: Many actors in search of a plot. Cell 83: 851-857.
5. Beug, H., M.J. Hayman, T. Graf, S.H. Benedict, A.M. Wallbank, and P.K. Vogt. 1985. S13, a rapidly oncogenic replication-defective avian retrovirus. Virology 145: 141-153.
6. Beug, H., R. Dahl, P. Steinlein, S. Meyer, E.M. Deiner, and M.J. Hayman. 1995. In vitro growth of factor-dependent multipotential hematopoietic cells is induced by the nuclear oncoprotein v-Ski. Oncogene 11: 59-72.
7. Brewer, G.J. and A.S. Prasad. 1993. Biochemistry and function of the erythron. In Hematology: Clinical and laboratory practice (ed. R.L. Bick), pp. 185-202. Mosby-Year Book, Inc., St. Louis, MO.
8. Broudy, V.C. 1997. Stem cell factor and hematopoiesis. Blood 90: 1345-1364.
9. Broudy, V.C., N.L. Lin, G.V. Priestley, K. Nocka, and N.S. Wolf. 1996. Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen. Blood 88: 75-81.
10. Chabot, B., D.A. Stephenson, V.M. Chapman, P. Besmer, and A. Bernstein. 1988. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335: 88-89.
11. Chang, T.J., B.M. Scher, S. Waxman, and W. Scher. 1993. Inhibition of mouse GATA-1 function by the glucocorticoid receptor: Possible mechanism of steroid inhibition of erythro-leukemia cell differentiation. Mol. Endocrinol. 7: 528-542.
12. Cole, P.J., J.A. Blendy, A.P. Monaghan, K. Kriegelstein, W. Schmid, A. Aguzzi, G. Fantuzzi, E. Hummler, K. Unsicker, and G. Schütz. 1995. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes & Dev. 9: 1608-1621.
13. Fisher, J.W. 1998. A quest for erythropoietin over nine decades. Annu. Rev. Pharmacol. Toxicol. 38: 1-20.
14. Galson, D.L., T. Tsuchiya, D.S. Tendler, L.E. Huang, Y. Ren, T. Ogura, and H.F. Bunn. 1995. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol. Cell. Biol. 15: 2135-2144.
15. Golde, D.W., N. Bersch, and M.J. Cline. 1976. Potentiation of erythropoiesis in vitro by dexamethasone. J. Clin. Invest. 57: 57-62.
16. Gottlicher, M., S. Heck, and P. Herrlich. 1998. Transcriptional cross-talk, the second mode of steroid hormone receptor action. J. Mol. Med. 76: 480-489.
17. Graf, T. and H. Beug. 1978. Avian leukemia viruses: Interaction with their target cells in vivo and in vitro. Biochim. Biophys. Acta 516: 269-299.
18. Guillemin, K. and M.A. Krasnow. 1997. The hypoxic response: Huffing and HIFing. Cell 89: 9-12.
19. Hara, H. and M. Ogawa. 1976. Erthropoietic precursors in mice with phenylhydrazine-induced anemia. Am. J. Hematol. 1: 453-458.
20. Harkness, J.E. and J.E. Wagner. 1995. The biology and medicine of rabbits and rodents. Williams & Wilkins, Baltimore, MD.
21. Lacombe, C. and P. Mayeux. 1998. Biology of erythropoietin. Haematologica 83: 724-732.
22. Liang, R., T.K. Chan, and D. Todd. 1994. Childhood acute lytnphoblastic leukaemia and aplastic anaemia. Leuk. Lymphoma 13: 411-415.
23. Lindemann, R., O. Trygstad, and S. Halvorsen, 1969. Pituitary control of erythropoiesis. Scand. J. Haematol. 6: 77-86.
24. Means, R.T.J. and E.N. Dessypris. 1993. The anemias of chronic disease, renal failure, and endocrine disorders. In Hematology: Clinical and laboratory practice (ed. R.L. Bick), pp. 419-429. Mosby-Year Book, Inc., St. Louis, MO.
25. Miller, W.L. and J.B. Tyrrell. 1995. The Adrenal Cortex. In Endocrinology and metabolism (ed. P. Fehlig, J.D. Baxter, and L.A. Frohman), pp. 555-711. McGraw-Hill, Inc., New York, NY.
26. Morrison, S.J., A.M. Wandycz, K. Akashi, A. Globerson, and I.L. Weissman. 1996. The aging of hematopoietic stem cells. Nat. Med. 2: 1011-1016.
27. Mucenski, M.L., K. McLain, A.B. Kier, S.H. Swerdlow, C.M. Schreiner, T.A. Miller, D.W. Pietryga, W.J. Scott Jr., and S.S. Potter. 1991. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65: 677-689.
28. Ou, L.C., D. Kim, W.M. Layton Jr., and R.P. Smith. 1980. Splenic erythropoiesis in polycythemic response of the rat to high-altitude exposure. J. Appl. Physiol. 48: 857-861.
29. Pevny, L., M.C. Simon, E. Robertson, W.H. Klein, S.F. Tsai, V. D'Agati, S.H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349: 257-260.
30. Reichardt, H.M., K.H. Kaestner, J. Tuckermann, O. Kretz, O. Wessely, R. Bock, P. Gass, W. Schmid, P. Herrlich, P. Angel, and G. Schütz. 1998. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93: 531-541.
31. Tronche, F., C. Kellendonk, H.M. Reichardt, and G. Schütz. 1998. Genetic dissection of glucocorticoid receptor function in mice. Curr. Opin. Genet. Dev. 8: 532-538.
32. Tronche, F., C. Kellendonk, O. Kretz, P. Gass, K. Anlag, O.P. C., R. Bock, R. Klein, and G. Schütz. 1999. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23: 99-103.
33. Uchida, N. and I.L. Weissman. 1992. Searching for hematopoietic stem cells: Evidence that Thy-1.1lo Lin-Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J. Exp. Med. 175: 175-184.
34. Udupa, K.B., H.M. Crabtree, and D.A. Lipschitz. 1986. In vitro culture of proerythroblasts: Characterization of proliferative response to erythropoietin and steroids. Br. J. Haematol. 62: 705-714.
35. Van Dyke, D.C., A.N. Contopoulos, B.S. Williams, M.E. Simpson, J.H. Lawrence, and H.M. Evans. 1954. Hormonal factors influencing erythropoiesis. Acta Haemat. 11: 203-222.
36. von Lindern, M., L. Boer, O. Wessely, M. Parker, and H. Beug. 1998. The transactivation domain AF-2 but not the DNA-binding domain of the estrogen receptor is required to inhibit differentiation of avian erythroid progenitors. Mol. Endocrinol. 12: 263-277.
37. von Lindern, M., W. Zauner, G. Mellitzer, P. Steinlein, G. Fritsch, K. Huber, B. Löwenberg, and H. Beug. 1999. The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitor in vitro. Blood 94: 550-559.
38. Wang, G.L. and G.L. Semenza. 1996. Molecular basis of hypoxia-induced erythropoietin expression. Curr. Opin. Hematol. 3: 156-162.
39. Wessely, O., E.M. Deiner, H. Beug, and M. von Lindern. 1997. The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J. 16: 267-280.
40. Wessely, O., A. Bauer, C.T. Quang, E.M. Deiner, M. von Lindern, G. Mellitzer, P. Steinlein, J. Ghysdael, and H. Beug. 1999. A novel way to induce erythroid progenitor self renewal: Cooperation of c-Kit with the erythropoietin receptor. Biol. Chem. 380: 187-202.
41. Wu, H., X. Liu, R. Jaenisch, and H.F. Lodish. 1995. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83: 59-67.
42. Zito, G.E. and E.C. Lynch. 1977. Prednisone-responsive congenital erythroid hypoplasia. J. Am. Med. Assoc. 237: 991-992.