Ouabain interactions with the H5-H6 hairpin of the Na,K-ATPase reveal a possible inhibition mechanism via the cation binding domain

Journal of Biological Chemistry

Volumn 271, Issue 24, 1996, Pages 14176-14182

  Palasis, Maria ^a   Kuntzweiler, Theresa A ^a   Argüello, José M ^a   Lingrel, Jerry B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BUFALIN; CARDIAC GLYCOSIDE; DIGITOXIN; DIGOXIN; OUABAGENIN; OUABAIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATION TRANSPORT; DNA SEQUENCE; DOSE RESPONSE; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; MUTAGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARDIAC GLYCOSIDES; CATIONS; CELL MEMBRANE; HELA CELLS; HUMANS; KINETICS; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; POINT MUTATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SHEEP; TRANSFECTION;

EID: 15844371622     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.24.14176     Document Type: Article

References (53)

1. Glynn, I. M. (1985) in Enzymes of Biological Membranes (Martonosi, A., ed) Vol. 3, pp. 35-114, Plenum Publishing Corp., New York
2. Bamberg, E., and Schoner, W. (eds) (1994) The Sodium Pump: Structure, Mechanism, Hormonal Control, and Its Role in Disease, Springer-Verlag Inc., New York
3. Lingrel, J. B, and Kuntzweiler, T. (1994) J. Biol. Chem. 269, 19659-19662
4. Jørgensen, P. L. (1992) in Molecular Aspects of Transport Proteins (De Pont. J. J., ed) pp. 1-26, Elsevier Science Publishers B. V., Amsterdam
5. Hansen, O. (1984) Pharmacol. Rev. 36, 143-163
6. Thomas, R., Gray, P., and Andrews, J. (1990) Adv. Drug Res. 19, 311-562
7. Forbush, B., III, Kaplan, J., and Hoffman, J. F. (1978) Biochemistry 17, 3667-3676
8. Rossi, B., Vuilleumier, P., Cache, C., Balerna, M., and Lazdunski, M. (1980) J. Biol. Chem. 255, 9936-9941
9. Antolovic, R., Schoner, W., Geering, K., Canesa, C., Rossier, B. C., and Horisberger, J. D. (1995) FEBS Lett. 368, 169-172
10. Jørgensen, P. L., Karlish, S. J. D., and Gilter, C. (1982) J. Biol. Chem. 257, 7435-7442
11. Price, E. M., and Lingrel, J. B (1988) Biochemistry 27, 8400-8408
12. Price, E. M., Rice, D. A., and Lingrel, J. B (1989) J. Biol. Chem. 264, 21902-21906
13. Price, E. M., Rice, D. A., and Lingrel, J. B (1990) J. Biol. Chem. 265, 6638-6641
14. Canfield, V., Emanuel, J. R., Speckofsky, N., Levenson, R., and Margolskee, R. F. (1990) Mol Cell. Biol. 10, 1367-1372
15. Canesa, C. M., Horisberger, J. D., Louvard, D., and Rossier, B. C. (1992) EMBO J. 11, 1681-1687
16. Schultheis, P. J., and Lingrel, J. B (1993) Biochemistry 32, 544-550
17. Schultheis, P. J., Wallick, E. T., and Lingrel, J. B (1993) J. Biol. Chem. 268, 22686-22694
18. Burns, E. L., and Price, E. M. (1993) J. Biol. Chem. 268, 25632-25635
19. Feng, J., and Lingrel, J. B (1994) Biochemistry 33, 4218-4224
20. Askew, G. R., and Lingrel, J. B (1994) J. Biol. Chem. 269, 24120-24126
21. Emanuel, J. R., Schulz, J., Zhou, X. M., Kent, R. B., Housman, D., Cantley, L., and Levenson, R. (1988) J. Biol. Chem. 263, 7726-7733
22. Ishii, T., and Takeyasu, K. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 8881-8885
23. Blostein, R., Zhang, R., Gottardi, C. J., and Caplan, M. J. (1993) J. Biol. Chem. 268, 10654-10658
24. Canessa, C. M., Horisberger, J. D., and Rossier, B. C. (1993) J. Biol. Chem. 268, 17722-17726
25. Yoda, A., and Yoda, S. (1975) Mol. Pharmacol. 11, 653-662
26. Wallick, E. T., and Schwartz, A. (1988) Methods Enzymol. 156, 201-213
27. Akera, T., and Brody, T. M. (1978) Pharmacol. Rev. 29, 311-562
28. Jewell-Motz, E. A., and Lingrel, J. B (1993) Biochemistry 32, 13523-13530
29. Argüello, J. M., and Kaplan, J. H. (1991) J. Biol. Chem. 266, 14627-14635
30. Argüello, J. M., and Kaplan, J. H. (1994) J. Biol. Chem. 269, 6892-6899
31. Vilsen, B. (1995) Biochemistry 34, 1455-1463
32. Feng, J., and Lingrel, J. B (1995) Cell. & Mol. Biol. Res. 41, 29-37
33. Lutsenko, S., and Kaplan, J. H. (1994) J. Biol. Chem. 269, 4555-4564
34. Lutsenko, S., Anderko, R., and Kaplan, J. H. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7936-7940
35. Argüello, J. M., and Lingrel, J. B (1995) J. Biol. Chem. 270, 22764-22771
36. Myers, R. M., Lerman, L. S., and Maniatis, T. (1985) Science 224, 242-247
37. Cadwell, R. C., and Joyce, G. F. (1992) PCR Methods and Appl. 2, 28-33
38. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) in Molecular Cloning: A Laboratory Manual, pp. 18.60-18.74, Cold Spring Harbor Laboratory Press, Plainview, NY
39. Malik, B., Jamieson, G. A., and Ball, W., Jr. (1993) Protein Sci. 2, 2103-2111
40. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
41. Lane, L. K., Copenhaver, J. H., Jr., Lindenmayer, G. E., and Schwartz, A. (1973) J. Biol. Chem. 248, 7197-7200
42. Jewell, E. A., and Lingrel, J. B (1991) J. Biol. Chem. 266, 16925-16930
43. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
44. Lanzetta, P. A., Alvarez, L. J., Reinach, P. S., and Candia, O. A. (1979) Anal. Biochem. 100, 5-97
45. Feller, W. (1970) in An Introduction to Probability Theory and Its Application, 3rd Ed., Wiley Publishing Co., New York
46. Schonfel, W., Weiland, J., Lindig, C., Masnyk, M., Kabat, M. M., Kurk, A., Wicha, J., and Repke, K. R. H. (1985) Naunyn-Schmiedeberg's Arch. Pharmacol. 329, 14-426
47. Green, N. M. (1994) in The Sodium Pump: Structure, Mechanism, Hormonal Control, and Its Role in Disease (Banberg, E., and Schoner, W., eds) pp. 110-119, Springer, New York
48. Baldwin, J. M. (1993) EMBO J. 12, 1693-1703
49. Gadsby, D. C., Rakowski, R. F., and DeWeer, P. (1993) Science 260, 100-103
50. Hilgemann, D. W. (1994) Science 263, 1429-1432
51. Jørgensen, P. L. (1992) Acta Physiol. Scand. 146, 89-94
52. Besancon, M., Shin, J. M., Mercier, F., Munson, K., Miller, M., Hersey, S. and Sachs, G. (1993) Biochemistry 32, 2345-2355
53. Shin, J. M., Besancon, M., Simon, A., and Sachs, G. (1993) Biochim. Biophys. Acta 1148, 223-233