Predicted location and limited accessibility of protein kinase A phosphorylation site on Na-K-ATPase

American Journal of Physiology - Cell Physiology

Volumn 280, Issue 4 49-4, 2001, Pages

  Sweadner, Kathleen J ^a   Feschenko, Marina S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Adenosine 3 ,5 cyclic monophosphate; Crystal structure

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM); CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL;

EID: 0035016483     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.280.4.c1017     Document Type: Article

References (16)

1. Altschul SF, Madden TL, Schaffer AA, Zhang J, Miller W, and Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402, 1997.
2. +-transporting ATPase. Biochemistry 34: 9508-9516, 1995.
3. Arystarkhova E, Gasparian M, Modyanov NN, and Sweadner KJ. Na,K-ATPase extracellular surface probed with a monoclonal antibody that enhances ouabain binding. J Biol Chem 267: 13694-13701, 1992.
4. Arystarkhova E, Gibbons DL, and Sweadner KJ. Topology of the Na,K-ATPase: evidence for externalization of a labile transmembrane structure during heating. J Biol Chem 270: 8785-8796, 1995.
5. Beguin P, Beggah A, Cotecchia S, and Geering K. Adrenergic, dopaminergic, and muscarinic receptor stimulation leads to PKA phosphorylation of Na-K-ATPase. Am J Physiol Cell Physiol 270: C131-C137, 1996.
6. Beguin P, Beggah AT, Chibalin AV, Burgener-Kairuz P, Jaisser F, Mathews PM, Rossier BC, Cotecchia S, and Geering K. Phosphorylation of the Na,K-ATPase α-subunit by protein kinases A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation. J Biol Chem 269: 24437-24445, 1994.
7. Bertorello A and Aperia A. Inhibition of proximal tubule Na,K-ATPase activity requires simultaneous activation of DA1 and DA2 receptors. Am J Physiol Renal Fluid Electrolyte Physiol 259: F924-F928, 1990.
8. +-ATPase inhibits the activity of the enzyme. Proc Natl Acad Sci USA 88: 11359-11362, 1991.
9. +)-ATPase activity in neostriatal neurons through D1 and D2 dopamine receptor synergism. Nature 347: 386-388, 1990.
10. +-ATPase activity by membrane insertion of α-subunits in lung alveolar cells. Am J Physiol Lung Cell Mol Physiol 276: L20-L27, 1999.
11. Blanco G, Sanchez G, and Mercer RW. Differential regulation of Na,K-ATPase isozymes by protein kinases and arachidonic acid. Arch Biochem Biophys 359: 139-150, 1998.
12. Borghini I, Geering K, Gjinovci A, Wollheim CB, and Pralong WF. In vivo phosphorylation of the Na,K-ATPase a subunit in sciatic nerves of control and diabetic rats: effects of protein kinase modulators. Proc Natl Acad Sci USA 91: 6211-6215, 1994.
13. Canfield VA and Levenson R. Transmembrane organization of the Na,K-ATPase determined by epitope addition. Biochemistry 32: 13782-13786, 1993.
14. + uptake and Na,K-ATPase α-subunit phosphorylation by a cAMP-dependent signalling pathway in intact cells from rat kidney cortex. FEBS Lett 396: 309-314, 1996.
15. +-ATPase. J Physiol (Lond) 518: 37-46, 1999.
16. 1-subunit in response to β-adrenergic hormone. Am J Physiol Cell Physiol 273: C893-C901, 1997.