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Volumn 71, Issue 7, 2001, Pages 941-950

HuM291(nuvion), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD69 ANTIGEN; FC RECEPTOR; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HUM291; PROTEIN ERK1; PROTEIN ERK2; PROTEIN TYROSINE KINASE; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VISILIZUMAB;

EID: 0035870674     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200104150-00020     Document Type: Article
Times cited : (32)

References (84)
  • 1
    • 0021816056 scopus 로고
    • A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants
    • (1985) N Engl J Med , vol.313 , Issue.6 , pp. 337
  • 2
    • 0023225834 scopus 로고
    • Overview of the development of Orthoclone OKT3: Monoclonal antibody for therapeutic use in transplantation
    • (1987) Transplant Proc , vol.19 , Issue.SUPPL. , pp. 1
    • Goldstein, G.1
  • 5
    • 0023274950 scopus 로고
    • Immunologic monitoring of Orthoclone OKT3-treated patients: The problem of antimonoclonal immune response
    • (1987) Transplant Proc , vol.19 , Issue.SUPPL. , pp. 17
    • Bach, J.F.1    Chatenoud, L.2
  • 12
    • 0344604333 scopus 로고    scopus 로고
    • A humanized anti-CD3 antibody, HuM291, with low mitogenic activity, mediates complete and reversible T-cell depletion in chimpanzees
    • (1999) Transplantation , vol.68 , Issue.4 , pp. 545
    • Hsu, D.H.1    Shi, J.D.2    Homola, M.3
  • 17
    • 0026091196 scopus 로고
    • Differential T cell hyporesponsiveness induced by in vivo administration of intact or F(ab′)2 fragments of anti-CD3 monoclonal antibody. F(ab′)2 fragments induce a selective T helper dysfunction
    • (1991) J Immunol , vol.147 , Issue.7 , pp. 2088
    • Hirsch, R.1    Archibald, J.2    Gress, R.E.3
  • 26
    • 0034650845 scopus 로고    scopus 로고
    • Enhancement of susceptibility to Fas-mediated apoptosis of TH1 cells by nonmitogenic anti-CD3epsilon F(ab′)2
    • (2000) Transplantation , vol.69 , Issue.1 , pp. 104
    • Yu, X.Z.1    Anasetti, C.2
  • 28
    • 0032524957 scopus 로고    scopus 로고
    • Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets
    • (1998) J Immunol , vol.160 , Issue.10 , pp. 4841
    • Smith, J.A.1    Tang, Q.2    Bluestone, J.A.3
  • 31
    • 0033593607 scopus 로고    scopus 로고
    • Differential signaling by variant ligands of the T cell receptor and the kinetic model of T cell activation
    • (1999) Life Sci , vol.64 , Issue.9 , pp. 717
    • Madrenas, J.1
  • 37
    • 0030008145 scopus 로고    scopus 로고
    • Variant TCR ligands: New insights into the molecular basis of antigen- dependent signal transduction and T-cell activation
    • (1996) Semin Immunol , vol.8 , Issue.2 , pp. 83
    • Madrenas, J.1    Germain, R.N.2
  • 43
    • 0033566749 scopus 로고    scopus 로고
    • Phospho-LAT-independent activation of the ras-mitogen-activated protein kinase pathway: A differential recruitment model of TCR partial agonist signaling
    • (1999) J Immunol , vol.163 , Issue.4 , pp. 1853
    • Chau, L.A.1    Madrenas, J.2
  • 48
    • 0029071585 scopus 로고
    • Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function
    • (1995) EMBO J , vol.14 , Issue.11 , pp. 2499
    • Chan, A.C.1    Dalton, M.2    Johnson, R.3
  • 52
    • 0027409792 scopus 로고
    • Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling
    • (1993) J Exp Med , vol.177 , Issue.4 , pp. 1047
    • Racioppi, L.1    Ronchese, F.2    Matis, L.A.3    Germain, R.N.4
  • 55
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
    • (1991) Nature , vol.353 , Issue.6347 , pp. 858
    • Lenardo, M.J.1
  • 58
    • 0029102761 scopus 로고
    • An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1544
    • Alegre, M.L.1    Tso, J.Y.2    Sattar, H.A.3
  • 72
    • 13044283432 scopus 로고    scopus 로고
    • Downregulation of antigen-presenting cell functions after administration of mitogenic anti-CD3 monoclonal antibodies in mice
    • (1999) Blood , vol.94 , Issue.12 , pp. 4347
    • Muraille, E.1    Andris, F.2    Pajak, B.3
  • 82
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • (2000) Immunity , vol.12 , Issue.4 , pp. 431
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 83
    • 0032192469 scopus 로고    scopus 로고
    • Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands
    • [erratum Immunity 1998; 9(6): 891.]
    • (1998) Immunity , vol.9 , Issue.4 , pp. 459
    • Boniface, J.J.1    Rabinowitz, J.D.2    Wulfing, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.