-
1
-
-
0014941813
-
A theory of self - Nonself discrimination
-
Bretscher P, Cohn M. A theory of self - nonself discrimination. Science. 169:1970;1042-1049.
-
(1970)
Science
, vol.169
, pp. 1042-1049
-
-
Bretscher, P.1
Cohn, M.2
-
2
-
-
0030300154
-
The complexities of T-cell costimulation: CD28 and beyond
-
Sperling AI, Bluestone JA. The complexities of T-cell costimulation: CD28 and beyond. Immunol Rev. 153:1996;155-182.
-
(1996)
Immunol Rev
, vol.153
, pp. 155-182
-
-
Sperling, A.I.1
Bluestone, J.A.2
-
3
-
-
0023266396
-
Stimulation of normal inducer T cell clones with antigen presented by purified la molecules in planar lipid membranes: Specific induction of a long-lived state of proliferative nonresponsiveness
-
Quill H, Schwartz RH. Stimulation of normal inducer T cell clones with antigen presented by purified la molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J Immunol. 138:1987;3704-3712.
-
(1987)
J Immunol
, vol.138
, pp. 3704-3712
-
-
Quill, H.1
Schwartz, R.H.2
-
4
-
-
0025058266
-
Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody
-
Jenkins MK, Chen CA, Jung G, Mueller DL, Schwartz RH. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J Immunol. 144:1990;16-22.
-
(1990)
J Immunol
, vol.144
, pp. 16-22
-
-
Jenkins, M.K.1
Chen, C.A.2
Jung, G.3
Mueller, D.L.4
Schwartz, R.H.5
-
5
-
-
0023143676
-
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
-
Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med. 165:1987;302-319.
-
(1987)
J Exp Med
, vol.165
, pp. 302-319
-
-
Jenkins, M.K.1
Schwartz, R.H.2
-
6
-
-
0026537347
-
CD28-mediated signalling co-stimulates murine T cells and prevents induction of energy in T cell clones
-
Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP. CD28-mediated signalling co-stimulates murine T cells and prevents induction of energy in T cell clones. Nature. 356:1992;607-610.
-
(1992)
Nature
, vol.356
, pp. 607-610
-
-
Harding, F.A.1
McArthur, J.G.2
Gross, J.A.3
Raulet, D.H.4
Allison, J.P.5
-
7
-
-
0027298445
-
Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
-
Sloan-Lancaster J, Evavold BD, Allen PM. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature. 363:1993;156-159.
-
(1993)
Nature
, vol.363
, pp. 156-159
-
-
Sloan-Lancaster, J.1
Evavold, B.D.2
Allen, P.M.3
-
8
-
-
0029933309
-
Altered peptide ligand induced partial T cell activation: Molecular mechanisms and role in T cell biology
-
of outstanding interest. The authors present a comprehensive review of signaling induced by, and the functional properties of, altered peptide ligands. Models of how partial signals are generated and the role of altered peptide ligands in various aspects of T cell biology are discussed.
-
Sloan-Lancaster J, Allen PM. Altered peptide ligand induced partial T cell activation: molecular mechanisms and role in T cell biology. of outstanding interest Annu Rev Immunol. 14:1996;1-27 The authors present a comprehensive review of signaling induced by, and the functional properties of, altered peptide ligands. Models of how partial signals are generated and the role of altered peptide ligands in various aspects of T cell biology are discussed.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 1-27
-
-
Sloan-Lancaster, J.1
Allen, P.M.2
-
9
-
-
0031048822
-
The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands
-
of outstanding interest. This study examines the role of the CD4 co-receptor in proximal TCR signaling. Limiting the association of CD4 with the TCR complex resulted in a partial agonist pattern of signaling and T cell clonal anergy.
-
Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. of outstanding interest J Exp Med. 185:1997;219-229 This study examines the role of the CD4 co-receptor in proximal TCR signaling. Limiting the association of CD4 with the TCR complex resulted in a partial agonist pattern of signaling and T cell clonal anergy.
-
(1997)
J Exp Med
, vol.185
, pp. 219-229
-
-
Madrenas, J.1
Chau, L.A.2
Smith, J.3
Bluestone, J.A.4
Germain, R.N.5
-
10
-
-
0019851727
-
Treatment of acute renal allograft rejection with OKT3 monoclonal antibody
-
Cosimi AB, Burton RC, Colvin B. Treatment of acute renal allograft rejection with OKT3 monoclonal antibody. Transplantation. 32:1981;535-539.
-
(1981)
Transplantation
, vol.32
, pp. 535-539
-
-
Cosimi, A.B.1
Burton, R.C.2
Colvin, B.3
-
11
-
-
0020957994
-
The human immune response to murine OKT3 monoclonal antibody
-
Jaffers GJ, Colvin RB, Cosimi AB, Giorgi JV, Goldstein G, Fuller TC, Kurnick JT, Lillehei C, Russell PS. The human immune response to murine OKT3 monoclonal antibody. Transplant Proc. 15:1983;646-648.
-
(1983)
Transplant Proc
, vol.15
, pp. 646-648
-
-
Jaffers, G.J.1
Colvin, R.B.2
Cosimi, A.B.3
Giorgi, J.V.4
Goldstein, G.5
Fuller, T.C.6
Kurnick, J.T.7
Lillehei, C.8
Russell, P.S.9
-
12
-
-
0025342326
-
Cytokine related syndrome following injection of anti-CD3 monoclonal antibody: Further evidence for transient in vivo T cell activation
-
Ferran C, Sheehan K, Dy M, Schreiber R, Merite S, Landais P, Noel L, Grau G, Bluestone JA, Bach JF, Chatenoud L. Cytokine related syndrome following injection of anti-CD3 monoclonal antibody: further evidence for transient in vivo T cell activation. Eur J Immunol. 20:1990;509-515.
-
(1990)
Eur J Immunol
, vol.20
, pp. 509-515
-
-
Ferran, C.1
Sheehan, K.2
Dy, M.3
Schreiber, R.4
Merite, S.5
Landais, P.6
Noel, L.7
Grau, G.8
Bluestone, J.A.9
Bach, J.F.10
Chatenoud, L.11
-
13
-
-
0027076729
-
Evidence that antihuman tumor necrosis factor monoclonal antibody prevents OKT3-induced acute syndrome
-
Charpentier B, Hiesse C, Lantz O, Ferran C, Stephens S, O'Shaugnessy D, Bodmer M, Benoit G, Bach JF, Chatenoud L. Evidence that antihuman tumor necrosis factor monoclonal antibody prevents OKT3-induced acute syndrome. Transplantation. 54:1992;997-1002.
-
(1992)
Transplantation
, vol.54
, pp. 997-1002
-
-
Charpentier, B.1
Hiesse, C.2
Lantz, O.3
Ferran, C.4
Stephens, S.5
O'Shaugnessy, D.6
Bodmer, M.7
Benoit, G.8
Bach, J.F.9
Chatenoud, L.10
-
14
-
-
0022610836
-
Fc receptors on monocytes cause OKT3-treated lymphocytes to internalize T3 and to secrete IL-2
-
Kan EAR, Wright SD, Welte K, Wang CY. Fc receptors on monocytes cause OKT3-treated lymphocytes to internalize T3 and to secrete IL-2. Cell Immunol. 98:1986;181-187.
-
(1986)
Cell Immunol
, vol.98
, pp. 181-187
-
-
Kan, E.A.R.1
Wright, S.D.2
Welte, K.3
Wang, C.Y.4
-
15
-
-
0025157238
-
Cross-linking of both FcγRI and FcγRII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-FcγR interactions: Functional activation of FcγRII by treatment with proteases or neuraminidase
-
Debets JM, Van de Winkel JG, Cueppens IE, Dieteren M, Buurman WA. Cross-linking of both FcγRI and FcγRII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-FcγR interactions: functional activation of FcγRII by treatment with proteases or neuraminidase. J Immunol. 144:1990;1304-1309.
-
(1990)
J Immunol
, vol.144
, pp. 1304-1309
-
-
Debets, J.M.1
Van De Winkel, J.G.2
Cueppens, I.E.3
Dieteren, M.4
Buurman, W.A.5
-
16
-
-
0025168113
-
Cross-linking Fc receptors on monocytes triggers IL-6 production. Role in anti-CD3 induced T cell activation
-
Krutmann J, Kirnbauer R, Kock A, Schwarz T, Schopf E, May T, Sehgal PB, Luger TA. Cross-linking Fc receptors on monocytes triggers IL-6 production. Role in anti-CD3 induced T cell activation. J Immunol. 145:1990;1337-1341.
-
(1990)
J Immunol
, vol.145
, pp. 1337-1341
-
-
Krutmann, J.1
Kirnbauer, R.2
Kock, A.3
Schwarz, T.4
Schopf, E.5
May, T.6
Sehgal, P.B.7
Luger, T.A.8
-
17
-
-
0025313268
-
Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb
-
Hirsch R, Bluestone JA, DeNenno L, Gress RE. Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb. Transplantation. 49:1990;1117-1120.
-
(1990)
Transplantation
, vol.49
, pp. 1117-1120
-
-
Hirsch, R.1
Bluestone, J.A.2
Denenno, L.3
Gress, R.E.4
-
18
-
-
0028178492
-
A non-activating humanized anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo
-
Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA. A non-activating humanized anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation. 57:1994;1537-1543.
-
(1994)
Transplantation
, vol.57
, pp. 1537-1543
-
-
Alegre, M.L.1
Peterson, L.J.2
Xu, D.3
Sattar, H.A.4
Jeyarajah, D.R.5
Kowalkowski, K.6
Thistlethwaite, J.R.7
Zivin, R.A.8
Jolliffe, L.9
Bluestone, J.A.10
-
19
-
-
0029102761
-
An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity
-
Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol. 155:1995;1544-1555.
-
(1995)
J Immunol
, vol.155
, pp. 1544-1555
-
-
Alegre, M.L.1
Tso, J.Y.2
Sattar, H.A.3
Smith, J.4
Desalle, F.5
Cole, M.6
Bluestone, J.A.7
-
20
-
-
0027458717
-
The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties
-
Bolt S, Routledge E, Lloyd I, Chatenoud L, Pope H, Gorman SD, Clark M, Waldmann H. The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. Eur J Immonol. 23:1993;403-411.
-
(1993)
Eur J Immonol
, vol.23
, pp. 403-411
-
-
Bolt, S.1
Routledge, E.2
Lloyd, I.3
Chatenoud, L.4
Pope, H.5
Gorman, S.D.6
Clark, M.7
Waldmann, H.8
-
21
-
-
0030896612
-
Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy
-
of outstanding interest. This study examines the biological and biochemical consequences of soluble anti-CD3 mAb treatment in naive T cells and T cell clones. Insufficient TCR aggregation by an FcR-nonbinding anti-CD3 mAb induces a signal similar to an altered peptide ligand signal, resulting in clonal, but not naive T cell anergy.
-
Smith JA, Tso JY, Clark MR, Cole MS, Bluestone JA. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. of outstanding interest J Exp Med. 185:1997;1413-1422 This study examines the biological and biochemical consequences of soluble anti-CD3 mAb treatment in naive T cells and T cell clones. Insufficient TCR aggregation by an FcR-nonbinding anti-CD3 mAb induces a signal similar to an altered peptide ligand signal, resulting in clonal, but not naive T cell anergy.
-
(1997)
J Exp Med
, vol.185
, pp. 1413-1422
-
-
Smith, J.A.1
Tso, J.Y.2
Clark, M.R.3
Cole, M.S.4
Bluestone, J.A.5
-
22
-
-
0023949756
-
Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses
-
Hirsch R, Eckhaus M, Auchincloss H Jr, Sachs DH, Bluestone JA. Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses. J Immunol. 140:1988;3766-3772.
-
(1988)
J Immunol
, vol.140
, pp. 3766-3772
-
-
Hirsch, R.1
Eckhaus, M.2
Auchincloss H., Jr.3
Sachs, D.H.4
Bluestone, J.A.5
-
23
-
-
0028014460
-
Signal transduction by lymphocyte antigen receptors
-
Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell. 76:1994;263-274.
-
(1994)
Cell
, vol.76
, pp. 263-274
-
-
Weiss, A.1
Littman, D.R.2
-
24
-
-
0029874657
-
T cell antigen receptor signal transduction pathways
-
of special interest. This is a comprehensive review of T cell receptor signal transduction, especially useful for its discussion of the Ras pathway and the biochemical signaling cascades that link the T cell receptor to the activation of nuclear transcription factors
-
Cantrell D. T cell antigen receptor signal transduction pathways. of special interest Annu Rev Immunol. 14:1996;259-274 This is a comprehensive review of T cell receptor signal transduction, especially useful for its discussion of the Ras pathway and the biochemical signaling cascades that link the T cell receptor to the activation of nuclear transcription factors.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 259-274
-
-
Cantrell, D.1
-
25
-
-
0028291525
-
JNK is involved in signal integration during costimulation of T lymphocytes
-
Su B, Jacinto E, Hibi M, Kallunki T, Kanin M, Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 77:1994;727-736.
-
(1994)
Cell
, vol.77
, pp. 727-736
-
-
Su, B.1
Jacinto, E.2
Hibi, M.3
Kallunki, T.4
Kanin, M.5
Ben-Neriah, Y.6
-
26
-
-
0027967385
-
Partial T cell signaling: Altered phospho-zeta and lack of ZAP70 recruitment in APL-induced T cell energy
-
Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM. Partial T cell signaling: altered phospho-zeta and lack of ZAP70 recruitment in APL-induced T cell energy. Cell. 79:1994;913-922.
-
(1994)
Cell
, vol.79
, pp. 913-922
-
-
Sloan-Lancaster, J.1
Shaw, A.S.2
Rothbard, J.B.3
Allen, P.M.4
-
27
-
-
0028902752
-
Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
-
Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 267:1995;515-518.
-
(1995)
Science
, vol.267
, pp. 515-518
-
-
Madrenas, J.1
Wange, R.L.2
Wang, J.L.3
Isakov, N.4
Samelson, L.E.5
Germain, R.N.6
-
28
-
-
0028209548
-
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
-
Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 263:1994;1136-1139.
-
(1994)
Science
, vol.263
, pp. 1136-1139
-
-
Iwashima, M.1
Irving, B.A.2
Van Oers, N.S.3
Chan, A.C.4
Weiss, A.5
-
29
-
-
0030888186
-
2+ response amplitude and duration
-
of special interest. Low calcium levels were sufficient to induce NF-AT translocation, but higher levels were required for NF-κB translocation in B cells. By extension, this study has implications for TCR signals which induce a low calcium flux level
-
2+ response amplitude and duration. of special interest Nature. 386:1997;855-858 Low calcium levels were sufficient to induce NF-AT translocation, but higher levels were required for NF-κB translocation in B cells. By extension, this study has implications for TCR signals which induce a low calcium flux level.
-
(1997)
Nature
, vol.386
, pp. 855-858
-
-
Dolmetsch, R.E.1
Lewis, R.S.2
Goodnow, C.C.3
Healy, J.I.4
-
30
-
-
0029847368
-
Functional diversity of helper T lymphocytes
-
Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
-
(1996)
Nature
, vol.383
, pp. 787-793
-
-
Abbas, A.K.1
Murphy, K.M.2
Sher, A.3
-
31
-
-
0028058940
-
Induction of T helper cell hyporesponsiveness in an experimental model of autoimmunity by using nonmitogenic anti-CD3 monoclonal antibody
-
Hughes C, Wolos JA, Giannini EH, Hirsch R. Induction of T helper cell hyporesponsiveness in an experimental model of autoimmunity by using nonmitogenic anti-CD3 monoclonal antibody. J Immunol. 153:1994;3319-3325.
-
(1994)
J Immunol
, vol.153
, pp. 3319-3325
-
-
Hughes, C.1
Wolos, J.A.2
Giannini, E.H.3
Hirsch, R.4
-
32
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
-
2 fragments resolved diabetes only after the onset of disease, but not when administered beforehand. This study has implications for the required activation state of the target T cells for anti-CD3 antibody treatment and for the mechanism of anti-CD3 induced cytokine deviation.
-
2 fragments resolved diabetes only after the onset of disease, but not when administered beforehand. This study has implications for the required activation state of the target T cells for anti-CD3 antibody treatment and for the mechanism of anti-CD3 induced cytokine deviation.
-
(1997)
J Immunol
, vol.158
, pp. 2947-2954
-
-
Chatenoud, L.1
Primo, J.2
Bach J-F3
-
33
-
-
0028157768
-
A common factor regulates both Th1- And Th2-specific cytokine gene expression
-
Rooney JW, Hodge MR, McCaffrey PG, Rao A, Glimcher LH. A common factor regulates both Th1- and Th2-specific cytokine gene expression. EMBO J. 13:1994;625-633.
-
(1994)
EMBO J
, vol.13
, pp. 625-633
-
-
Rooney, J.W.1
Hodge, M.R.2
McCaffrey, P.G.3
Rao, A.4
Glimcher, L.H.5
-
34
-
-
0029030775
-
Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
-
Rooney JW, Hoey T, Glimcher LH. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity. 2:1995;473-483.
-
(1995)
Immunity
, vol.2
, pp. 473-483
-
-
Rooney, J.W.1
Hoey, T.2
Glimcher, L.H.3
-
35
-
-
0030966218
-
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
-
of special interest. This study compares B cell receptor signaling in tolerant and nontolerant hen egg lysozyme specific B cells. In tolerant cells, NF-AT and mitogen activated protein kinase are chronically activated, yet still further inducible. cJun amino terminal kinase (JNK) activation, however, is defective
-
Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. of special interest Immunity. 6:1997;419-428 This study compares B cell receptor signaling in tolerant and nontolerant hen egg lysozyme specific B cells. In tolerant cells, NF-AT and mitogen activated protein kinase are chronically activated, yet still further inducible. cJun amino terminal kinase (JNK) activation, however, is defective.
-
(1997)
Immunity
, vol.6
, pp. 419-428
-
-
Healy, J.I.1
Dolmetsch, R.E.2
Timmerman, L.A.3
Cyster, J.G.4
Thomas, M.L.5
Crabtree, G.R.6
Lewis, R.S.7
Goodnow, C.C.8
-
36
-
-
0030057218
-
T cell activation determined by T cell receptor number and tunable thresholds
-
Viola A, Lanzavecchia A. T cell activation determined by T cell receptor number and tunable thresholds. Science. 273:1996;104-106.
-
(1996)
Science
, vol.273
, pp. 104-106
-
-
Viola, A.1
Lanzavecchia, A.2
-
37
-
-
1842373718
-
Duration of TCR stimulation determines costimulatory requirement of T cells
-
Kundig TM, Shahinian A, Kawai K, Mittrucker HW, Sebzda E, Bachmann MF, Mak TW, Ohashi PS. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity. 5:1996;41-52.
-
(1996)
Immunity
, vol.5
, pp. 41-52
-
-
Kundig, T.M.1
Shahinian, A.2
Kawai, K.3
Mittrucker, H.W.4
Sebzda, E.5
Bachmann, M.F.6
Mak, T.W.7
Ohashi, P.S.8
-
38
-
-
0030927323
-
Making the T cell receptor go the distance: A topological view of T cell activation
-
Shaw AS, Dustin ML. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity. 6:1997;361-369.
-
(1997)
Immunity
, vol.6
, pp. 361-369
-
-
Shaw, A.S.1
Dustin, M.L.2
-
39
-
-
0026332710
-
Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-κB-like response element
-
Verweij CL, Geerts M, Aarden LA. Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-κB-like response element. J Biol Chem. 266:1991;14179-14182.
-
(1991)
J Biol Chem
, vol.266
, pp. 14179-14182
-
-
Verweij, C.L.1
Geerts, M.2
Aarden, L.A.3
|