Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-induced apoptosis

Experimental Cell Research

Volumn 265, Issue 1, 2001, Pages 145-151

  Feng Gao, Chong ^a   Ren, Shuo ^a   Zhang, Lilin ^a   Nakajima, Takuma ^a   Ichinose, Shizuko ^a   Hara, Toshiko ^b   Koike, Katsuro ^b   Tsuchida, Nobuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

Apoptosis; Bax; Caspase 8; Cytochrome c; p53

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; PROTEIN BAX; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0035870123     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5171     Document Type: Article

References (40)

1. p53, the cellular gatekeeper for growth and division
2. Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis
3. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha
4. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
5. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
6. Induction of the growth inhibitor IGF-binding protein 3 by p53
7. A model for p53-induced apoptosis
8. Apoptosis by death factor
9. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
10. Mitochondria and apoptosis
11. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
12. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
13. Activation of caspases in p53-induced transactivation-independent apoptosis
14. Induction of apoptosis in HeLa cells by trans-activation-deficient p53
15. Caspases: Intracellular signaling by proteolysis
16. p53-induced apoptosis in the human T-ALL cell line CCRF-CEM
17. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
18. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release
19. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2
20. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
21. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
22. Val138: Modulation of the cell cycle viability and expression of p53 responsive genes
23. ATP-dependent steps in apoptotic signal transduction
24. Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2
25. Mitochondrial control of cell death
26. Smac, a mitochondrial protein that promotes cytochrome c dependent caspase activation by eliminating IAP inhibition
27. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
28. Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis
29. Inhibition of Bax channel-forming activity by Bcl-2
30. Bax directly induces release of cytochrome c from isolated mitochondria
31. Regulated targeting of BAX to mitochondria
32. Cytosol-tomembrane redistribution of Bax and Bcl-XL during apoptosis
33. Movement of Bax from the cytosol to mitochondria during apoptosis
34. Altered sensitivity to retinoid-induced apoptosis associated with changes in the subcellular distribution of Bcl-2
35. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
36. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
37. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
38. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
39. Interleukin 1 beta converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis
40. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane