Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor- 4α/MODY1 gene

Diabetes

Volumn 46, Issue 11, 1997, Pages 1749-1754

  Herman, William H ^a,d   Fajans, Stefan S ^a   Smith, Maria J ^a,b   Polonsky, Kenneth S ^c   Bell, Graeme I ^c   Halter, Jeffrey B ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUCAGON; INSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GLUCAGON RELEASE; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RELEASE; MALE; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0030695028     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.11.1749     Document Type: Article

References (28)

1. Fajans SS: Scope and heterogeneous nature of MODY. Diabetes Care 13:49-64, 1990 (Erratum Diabetes Care 13:910, 1990)
2. Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI: Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1). Mature 384:458-460, 1996
3. Bell GI, Xiang K, Newman MV, Wu S, Wright LG, Fajans SS, Spielman RS, Cox NJ: Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci U S A 88:1484-1488, 1991
4. Bowden DW, Gravius TC, Akots G, Fajans SS: Identification of genetic markers flanking the maturity-onset of the young locus on human chromosome 20. Diabetes 41:88-92, 1992
5. Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, Sun F, Lesage S, Stoffel M, Takeda J, Passa P, Permult MA, Beckmann JS, Bell GI, Cohen D: Familial hyperglycemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. N Engl J Med 328:697-702, 1993
6. Vamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda N, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Turner RC, Velho G, Chèvre J, Froguel P, Bell GL: Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 384:455-458, 1996
7. Vaxillaire M, Boccio V, Phillippi A, Bigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P: A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat Genet 9:418-423, 1995
8. Menzel S, Yamagata K, Trabb JB, Nerup J, Permutt MA, Fajans SS, Menzel R, Iwasaki N, Omori Y, Cox NJ, Bell GI: Localization of MODY3 to a 5 cM region of human chromosome 12. Diabetes 44:1408-1413, 1995
9. Herman WH, Fajans SS, Ortiz FJ, Smith MJ, Sturis J, Bell GI, Polonsky KS, Halter JB: Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree. Diabetes 43:40-46, 1994
10. Byrne MM, Sturis J, Fajans SS, Ortiz FJ, Stoltz A, Stoffel M, Smith MJ, Bell GI, Halter JB, Polonsky KS: Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 44:699-704, 1995
11. Velho G, Froguel P, Clément K, Pueyo ME, Rakotoambinína B, Zouali H, Passa P, Cohen D, Robert JJ: Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 340:444-448, 1992
12. Byrne MM, Sturis J, Clement K, Vionnet N, Pueyo ME, Stoffel M, Takeda J, Passa P, Cohen D, Bell GI, Velho G, Froguel P, Polonsky KS: Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest 93:1120-1130, 1994
13. Byrne MM, Sturis J, Menzel S, Yamagata K, Fajans SS, Dronsfield MJ, Bain SC, Hattersley AT, Velho G, Froguel P, Bell GI, Polonsky KS: Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes mellitus susceptibility gene MODY3 on chromosome 12. Diabetes 45:1503-1510, 1996
14. Fajans SS, Bell GI, Bowden DW, Halter JB, Polonsky KS: Minireview: maturity-onset diabetes of the young. Life Sci 55:413-422, 1994
15. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
16. Cox NJ, Xiang K, Fajans SS, Bell GI: Mapping diabetes-susceptibility genes: lessons learned from the search for a DNA marker for MODY. Diabetes 41:401-407, 1992
17. Rothschild CB, Akots G, Hayworth R, Pettenati MJ, Rao PN, Wood P, Stolz FM, Hansmann I, Serino K, Keith TP, Fajans SS, Bowden DW: A genetic map of chromosome 10q12-113.1: multiple highly poly-morphic microsatellite and RFLP markers linked to the maturity-onset diabetes of the young (MODY) locus. Am J Hum Genet 52:110-23, 1993
18. Hayashi M, Floyd JC Jr, Pek S, Fajans SS: Insulin, proinsulin, glucagon, and gastrin in pancreatic tumors and in plasma of patients with organic hyperinsulinism. J Clin Endocrinol Metab 44:681-694, 1977
19. Faber OK, Binder C, Markussen J, Heding LG, Naithani VK, Kuzuya H, Blix P, Horwitz DL, Rubenstein AH: Characterization of seven C-peptide antisera. Diabetes 27:170-177, 1978
20. Polonsky KS, Licinio-Paixao J, Given BD, Pugh W, Rue P, Galloway J, Karrison T, Frank B: Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77:98-105, 1986
21. Halter JB, Graf RJ, Porte D Jr. Potentiation of insulin secretory responses by plasma glucose levels in man: evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation. J Clin Endocrinol Metab 48:946-954, 1979
22. Fajans SS, Floyd JC Jr, Knopf RF, Conn JW: Effect of amino acids and proteins on insulin secretion in man. Recent Prog Horm Res 23:617-662, 1967
23. Floyd JC Jr, Fajans SS, Pek S, Thiffault CA, Knopf RF, Conn JW: Synergistic effect of essential amino acids and glucose upon insulin secretion in man. Diabetes 19:109-115, 1970
24. Newgard CB, McGarry JD: Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu Rev Biochem 64:689-719, 1995
25. Unger RH, Aguilar-Parada E, Müller WA, Eisentraut AM: Studies of pancreatic alpha cell function in normal and diabetic subjects. J clin Invest 49:837-848, 1970
26. Raskin P, Aydin I, Unger RH: Effect of insulin on the exaggerated glucagon response to arginine stimulation in diabetes mellitus. Diabetes 25:227-229, 1976
27. Zangen DH, Boner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC: Reduced insulin, GLUT2, and IDX-1 in β-cells after partial pancreatectomy. Diabetes 46:258-264, 1997
28. Lukinius A, Ericsson JLE, Grimelius L, Korsgren O: Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones. Dev Biol 153:376-385, 1992