(2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D- coupled metabotropic glutamate receptors: Asymmetric synthesis and preliminary biological properties

Journal of Medicinal Chemistry

Volumn 42, Issue 14, 1999, Pages 2716-2720

  Pellicciari, Roberto ^a   Marinozzi, Maura ^a   Costantino, Gabriele ^a   Natalini, Benedetto ^a   Moroni, Flavio ^b   Pellegrini Giampietro, Domenico ^b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CARBOXY 3 PHENYLCYCLOPROPYL)GLYCINE; 2 (2' CARBOXY 3' PHENYLCYCLOPROPYL)GLYCINE; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; NONHUMAN; PATHOPHYSIOLOGY; RAT; STEREOCHEMISTRY;

ANIMALS; CYCLOLEUCINE; CYCLOPROPANES; GLYCEROPHOSPHOLIPIDS; GLYCINE; HIPPOCAMPUS; PHOSPHOLIPASE C; PHOSPHOLIPASE D; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM;

EID: 0033566221     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990128v     Document Type: Article

References (19)

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