Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: Electrophilic catalysis of uracil expulsion by a neutral histidine 187

Biochemistry

Volumn 38, Issue 37, 1999, Pages 11876-11886

  Drohat, Alexander C ^a   Xiao, Gaoyi ^a   Tordova, Maria ^a   Jagadeesh, Jaya ^a   Pankiewicz, Krzysztof W ^b   Watanabe, Kyoichi A ^b   Gilliland, Gary L ^b   Stivers, James T ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b PHARMASSET INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

URACIL DNA GLYCOSYLTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; DNA REPAIR; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARBON ISOTOPES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DNA GLYCOSYLASES; ENZYME STABILITY; ESCHERICHIA COLI; GLUTAMINE; HISTIDINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MUTAGENESIS, SITE-DIRECTED; N-GLYCOSYL HYDROLASES; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTONS; SUBSTRATE SPECIFICITY; URACIL; URACIL-DNA GLYCOSIDASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS PHAGE 187;

EID: 0033554395     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9910880     Document Type: Article

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