Induced N- and C-terminal cleavage of p53: A core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53

EMBO Journal

Volumn 16, Issue 19, 1997, Pages 6008-6017

  Okorokov, Andrei L ^a   Ponchel, Frederique ^a   Milner, Jo ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Activation; Autoproteolysis; DNA damage; mdm 2; p53

Indexed keywords

BESTATIN; CELL DNA; CISPLATIN; DOXORUBICIN; PROTEIN P53; PROTEINASE; SINGLE STRANDED DNA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA INTERACTION; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DNA; DNA DAMAGE; DNA, SINGLE-STRANDED; HUMANS; KINETICS; LEUCINE; MICE; MICROCHEMISTRY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

ANIMALIA;

EID: 0030826733     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.19.6008     Document Type: Article

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