Zidovudine and dideoxynucleosides deplete wild-type mitochondrial DNA levels and increase deleted mitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1316, Issue 1, 1996, Pages 51-59

  Wang, Huayan ^a   Lemire, Bernard D ^a   Cass, Carol E ^a   Weiner, Joel H ^a   Michalak, Marek ^a   Penn, Andrew M W ^a   Fliegel, Larry ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3' Azido 2',3' dideoxythymidine; Kearns Sayre syndrome; Mitochondrion; Polymerase chain reaction; Zidovudine

Indexed keywords

2',3' DIDEOXYGUANOSINE; DNA; ZALCITABINE; ZIDOVUDINE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOCHEMISTRY; FIBROBLAST; GENE DELETION; HUMAN; HUMAN CELL; KEARNS SAYRE SYNDROME; MITOCHONDRION; PRIORITY JOURNAL;

EID: 0029882328     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/0925-4439(96)00015-4     Document Type: Article

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