Substrates of DNA polymerases with planar conformation of sugar: Model of substrate transition state?

Nucleosides and Nucleotides

Volumn 17, Issue 7, 1998, Pages 1153-1162

  Krayevsky, Alexander A ^a   Watanabe, Kyoichi A ^b  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b Division of Medicinal Chemistry   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; SUGAR;

ARTICLE; CARBOHYDRATE ANALYSIS; CONFORMATIONAL TRANSITION; ENZYME SUBSTRATE; STRUCTURE ANALYSIS;

EID: 0031801189     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319808004228     Document Type: Article

References (37)

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37. It may be argued that ACG-TP is not a substrate for HIV reverse transcriptase but is a substrate of HSV DNA polymerase. Thus, these enzymes should not belong to the same class. It should be noted that nucleosides that lack an hydroxyl group in the C3′ position do not necessarily be the substrates of all the type 2 DNA polymerases. The type 1 polymerases do require 3′-OH, but all nucleosides with 3′-OH are not necessarily the substrates. Thus, some nucleosides are more selective to a particular polymerase than others of the same category.