Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim

Acta Biochimica Polonica

Volumn 48, Issue 4, 2001, Pages 903-916

  Nowak, Wieslaw ^a   Cody, Vivian ^b   Wojtczak, Andrzej ^a  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b NONE

Author keywords

Chemotherapy; Computer modeling; Dihydrofolate reductase; Enzyme structure; ESFF forcefield; NADPH; Piritrexim

Indexed keywords

ANTINEOPLASTIC AGENT; DIHYDROFOLATE REDUCTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PIRITREXIM; PYRIMIDINE DERIVATIVE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; GENETICS; HUMAN; METABOLISM; MUTATION; POINT MUTATION; PROTEIN BINDING;

ANTINEOPLASTIC AGENTS; BINDING SITES; HUMANS; MODELS, MOLECULAR; MUTATION; NADP; POINT MUTATION; PROTEIN BINDING; PYRIMIDINES; SOFTWARE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0035756319     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.2001_3856     Document Type: Article

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