The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate

Journal of Molecular Biology

Volumn 277, Issue 1, 1998, Pages 119-134

  Gargaro, Angelo R ^a   Soteriou, Alice ^a   Frenkiel, Thomas A ^b   Bauer, Christopher J ^b   Birdsall, Berry ^a   Polshakov, Vladimir I ^c   Barsukov, Igor L ^d   Roberts, Gordon C K ^d   Feeney, James ^a  

^a NW7 1AA ^*  (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c Center for Drug Chemistry   (Russian Federation)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

DHFR; Methotrexate; NADPH; NMR; Structure

Indexed keywords

DIHYDROFOLATE REDUCTASE; GLUTAMIC ACID; METHOTREXATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; HYDROGEN BOND; LACTOBACILLUS CASEI; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; SIMULATION; X RAY CRYSTALLOGRAPHY;

LACTOBACILLUS CASEI; POSIBACTERIA;

EID: 0032549577     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1560     Document Type: Article

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