Computational predictions of binding affinities to dihydrofolate reductase: Synthesis and biological evaluation of methotrexate analogues

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3852-3861

  Graffner Nordberg, M ^a   Marelius, J ^a   Ohlsson, S ^b   Persson, A ^b   Swedberg, G ^a   Andersson, P ^b   Andersson, S E ^c   Aqvist, J ^a   Hallberg, A ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; METHOTREXATE DERIVATIVE;

ANIMAL EXPERIMENT; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INDICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; NONHUMAN; PREDICTION; RAT; RECEPTOR AFFINITY;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL AVAILABILITY; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; MALE; METHOTREXATE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN BINDING; RATS; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 0034687230     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0009639     Document Type: Article

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