Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523

Biochemistry

Volumn 36, Issue 45, 1997, Pages 13897-13903

  Cody, Vivian ^a   Galitsky, Nikolai ^a   Luft, Joseph R ^a   Pangborn, Walter ^a   Rosowsky, Andre ^b   Blakley, Raymond L ^c  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN FOLDING; STRUCTURE ANALYSIS;

BINDING, COMPETITIVE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; HUMANS; NADP; ORNITHINE; PROTEIN BINDING; PTERINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0030656217     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971711l     Document Type: Article

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