Transforming growth factor-β1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo

Cancer Research

Volumn 60, Issue 16, 2000, Pages 4531-4537

  Bouzahzah, Boumediene ^a   Fu, Maofu ^a   Iavarone, Antonio ^a   Factor, Valentina M ^b   Thorgeirsson, Snorri S ^b   Pestell, Richard G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; HISTONE DEACETYLASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME BINDING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; REPRESSOR GENE; TRANSGENIC MOUSE;

ANIMALS; CDC25 PHOSPHATASE; CELL DIVISION; HELA CELLS; HEPATECTOMY; HISTONE DEACETYLASES; HUMANS; LIVER; LIVER REGENERATION; MALE; MICE; MICE, TRANSGENIC; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; VIRAL STRUCTURAL PROTEINS;

EID: 0034662633     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. The transforming growth factor-βs
2. Biology of TGF-β in knockout and transgenic mouse models
3. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
4. Inactivation of the type II TGFβ receptor in colon cancer cells with microsatellite instability
5. Tumor suppressor activity of the TGFβ pathway in human cancers
6. Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency
7. The recombinant proregion of transforming growth factor β1 (latency-associated peptide) inhibits active transforming growth factor β1 in transgenic mice
8. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β
9. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
10. CDC25 phosphatase as potential human oncogenes
11. Cdc25A is a novel phosphatase functioning early in the cell cycle
12. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation
13. The retinoblastoma protein and cell cycle control
14. The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif
15. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth
16. Retinoblastoma protein switches the E2F site from positive to negative element
17. Retinoblastoma protein recruits histone deacetylase to repress transcription
18. Rb interacts with histone deacetylase to repress transcription
19. Histone acetylation and transcriptional regulatory mechanisms
20. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
21. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase
22. Cdc25 cell-cycle phosphatase as a target of c-myc
23. E2F and histone deacetylase mediate transforming growth factor-β repression of cdc25A during keratinocyte cell cycle arrest
24. A potential role for cell cycle control proteins in regulation of the cyclin adenosine 5′-monophosphate-responsive glycoprotein hormone α subunit gene
25. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
26. Induction of cyclin D1 by simian virus 40 small tumor antigen
27. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression
28. HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex
29. Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions
30. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
31. Histone deacetylase 1 can repress transcription by binding to Spl
32. Histone deacetylase associated with the sin3 corepressor mediate Mad transcriptional repression
33. c-Myc target gene specificity is determined by a post-DNA binding mechanism
34. TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest
35. Kip1
36. Transforming growth factor β stabilizes p151NK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells
37. The transforming growth factor β-s
38. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state
39. pRb and p107/130 are required for the regulated expression of different sets of E2F response genes
40. Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1
41. Transcriptional repression. The cancer-chromatin connection
42. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
43. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus