EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism

Clinical and Experimental Metastasis

Volumn 14, Issue 1, 1996, Pages 61-72

  Segall, Jeffrey E ^a   Tyerech, Sangeeta ^a   Boselli, Lucia ^a   Masseling, Susan ^a   Helft, Joseph ^a   Chan, Amanda ^a   Jones, Joan ^a   Condeelis, John ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Chemotaxis; EGF; Metastasis; Motility

Indexed keywords

ACTIN; CYTOCHALASIN D; EPIDERMAL GROWTH FACTOR; NOCODAZOLE; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST ADENOCARCINOMA; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; METASTASIS; NONHUMAN; RAT;

EID: 0030061065     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00157687     Document Type: Article

References (24)

1. Rosenberg S, 1987, Surgical Treatment of Afetastatic Cancer. Lippincott: Philadelphia.
2. Fidler U and Balch CM, 1987, The biology of cancer metastasis and implications for therapy. Curr Prob Surg, 24, 129-209.
3. Sugarbaker EV, 1979, Cancer metastasis: a product of tumor-host interactions. Curr Prob Cancer, 3, 1-59.
4. Nabi IR, Watanabe H and Raz A, 1992, Autocrine motility factor and its receptor: role in cell locomotion and metastasis. Cancer Metastasis Rev, 11, 5-20.
5. Talmadge JE and Fidler IJ, 1989, Phenotypic heterogeneity and metastasis. In: Sirica AE, ed. The Pathobiology of Neoplasia. New York:Plenum Press, pp. 547-72.
6. Lu C and Kerbel RS, 1994, Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. Curr Opin Oncol, 6, 212-20.
7. Yeatman TJ and Nicolson GL, 1993, Molecular basis of tumor progression: mechanisms of organ-specific tumor metastasis. Seminars Surg Oncol, 9, 256-63.
8. Rinker-Schaeffer CW, Partin AW, Isaacs WB, et al. 1994, Molecular and cellular changes associated with the acquisition of metastatic ability by prostatic cancer cells. Prostate, 25, 249-265.
9. Monsky WL and Chen WT, 1993, Proteases of cell adhesion proteins in cancer. Seminars Cancer Biol, 4, 251-8.
10. Aznavoorian S, Murphy AN, Stetler-Stevenson WG, et al. 1993, Molecular aspects of tumor cell invasion and metastasis. Cancer, 71, 1368-83.
11. Jones JG, Segall J and Condeelis J, 1991, Molecular analysis of amoeboid chemotaxis: parallel observations in amoeboid phagocytes and metastatic tumor cells. Experientia Suppl, 59, 1-16.
12. Condeelis J, 1993, Life at the leading edge: the formation of cell protrusion. Ann Rev Cell Biol, 9, 411-44.
13. Devreotes PN and Zigmond SH, 1988, Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelhtm. Ann Rev Cell Biol, 4, 649-86.
14. Silletti S and Raz A, 1993, Autocrine motility factor is a growth factor. Biochetn Biophys Res Commun, 194, 446-57.
15. Stracke M, Liotta LA and Schiffmann E, 1993, The role of autotaxin and other motility stimulating factors in the regulation of tumor cell motility. Symp Soc Exp Biol, 47, 197-214.
16. Hoelting T, Siperstein AE, Clark OH, et al. 1994, Epidermal growth factor enhances proliferation, migration, and invasion of follicular and papillary thyroid cancer in vitro and in vivo. J Clin Endocr Metab, 79, 401-8.
17. Pedersen PH, Ness GO, Engebraaten O, et al. 1994, Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF-alpha, bFGF, IL-2] on glioma spheroid growth, migration and invasion. Int J Cancer, 56, 255-61.
18. Wang X, Kamiyama K, Iguchi I, et al. 1994, Enhancement of fibronectin-induced migration of corneal epithelial cells by cytokines. Invest Ophthalmol Vis Sci, 35, 4001-7.
19. Royce LS and Baum BJ, 1991, Physiologic levels of salivary epidermal growth factor stimulate migration of an oral epithelial cell line. Biochim Biophys Acta, 1092, 401-3.
20. Grotendorst GR, Soma Y, Takehara K, et al. 1989, EGF and TGF-alpha are potent chemoattractants for endothelial cells and EGF-like peptides are present at sites of tissue regeneration. J Cell Physiol, 139, 617-23.
21. Blay J and Brown KD, 1985, Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells. J Cell Physiol, 124, 107-12.
22. Kundra V, Escobedo JA, Kazlauskas A, et al. 1994, Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature, 367, 474-6.
23. Yenush L, Kundra V, White MF, et al. 1994, Functional domains of the insulin receptor responsible for chemotactic signaling. J Biol Chem, 269, 100-4.
24. Li Y, Bhargava MM, Joseph A, et al. 1994, Effect of hepatocyte growth factor/scatter factor and other growth factors on motility and morphology of non-tumorigenic and tumor cells. In Vitro Cell Devel Biol An, 30A, 105-10.