Autoinhibition mechanism of proto-Dbl

Molecular and Cellular Biology

Volumn 21, Issue 5, 2001, Pages 1463-1474

  Bi, F ^a   Debreceni, B ^a   Zhu, K ^a   Salani, B ^a   Eva, A ^a   Zheng, Y ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PLECKSTRIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL TRANSFORMATION; CYTOSKELETON; GENE ACTIVATION; GENE TARGETING; INSECT; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTO ONCOGENE;

3T3 CELLS; ACTINS; ANIMALS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CDC42 GTP-BINDING PROTEIN; CELL LINE; CELL NUCLEUS; COS CELLS; CYTOSKELETON; DNA, COMPLEMENTARY; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE DELETION; GLUTATHIONE TRANSFERASE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; INSECTS; MICE; MICROSCOPY, FLUORESCENCE; MUTAGENESIS, SITE-DIRECTED; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; RHO GTP-BINDING PROTEINS; STRESS FIBERS; TIME FACTORS; TRANSFECTION;

ANIMALIA; INSECTA;

EID: 0035138272     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.5.1463-1474.2001     Document Type: Article

References (55)

1. 2-terminal sequences in the negative regulation of Vav signaling and transforming activity
2. Structure and mutagenesis of the Dbl homology domain
3. Structural basis for relief of autoinhibition of the Dbl homology domain of protooncogene Vav by tyrosine phosphorylation
4. Activation of RhoA and SAPK/JNK signaling pathways by the RhoA-specific exchange factor mNET1
5. Gα13 requires palmitoylation for plasma membrane localization. Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding
6. The structural basis of the activation of Ras by Sos
7. The role of Far1p in linking the heterotrimeric G protein to polarity estblishment proteins during yeast mating
8. The Dbl family of oncogenes
9. GEFs: Structural basis for their activation of small GTP-binding proteins
10. Modular binding domains in signal transduction proteins
11. Regulation of SOS activity by intramolecular interactions
12. Phosphotyrosine dependent activation of Rac1 GDP/GTP exchange by the vav proto-oncogene product
13. 2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation
14. Structural basis for activation of ARF GTPase: Mechanism of guanine nucleotide exchange and GTP-myristoyl switch
15. The human dbl proto-oncogene product is a cytoplasmic phosphoprotein which is associated with the cytoskeletal matrix
16. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for rho-like proteins
17. Rho GTPases and the actin cytoskeleton
18. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
19. Direct stimulation of the guanine nucleotide exchange activity of p115RhoGEF by Gα13
20. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
21. A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways
22. Asef, a link between the tumor suppressor APC and G-protein signaling
23. Dbl and Vav mediated transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras
24. Activation of Rac and Rho and mitogen-activated protein kinases are required for Ras transformation
25. Autoinhibition and activation mechanism of the Wiskott-Aldrich syndrome protein
26. Induction of Rac-guanine nucleotide exchange activity of RasGRF1/Cdc25Mm following phosphorylation by the nonreceptor tyrosine kinase Src
27. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
28. Residues of the Rho family GTPases Rho and Cdc42Hs that specify sensitivity to Dbl-like guanine nucleotide exchange factors
29. Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of the small GTPase Cdc42
30. Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation
31. NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio
32. A role for Rac in Tiam1-induced membrane ruffling and invasion
33. Oncogene ect2 is related to regulators of small GTP-binding proteins
34. A Cdc24p-Far1p-Gbg protein complex required for yeast orientation during mating
35. Association of the proto-oncogene product Dbl with G protein βγ subunits
36. Distinct involvment of Cdc42 and RhoA GTPases in actin organization and cell shape in untransformed and Dbl oncogene transformed NIH 3T3 cells
37. Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases
38. Distinct roles for the DH and PH domains in the Lbc oncogene
39. Protein modules and signaling networks
40. N terminus of Sos1 Ras exchange factor: Critical roles for the Dbl and pleckstrin homology domains
41. Molecular cloning and characterization of the human dbl proto-oncogene: Evidence that its overexpression is sufficient to transform NIH3T3 cells
42. The N-terminal region of proto-dbl down regulates its transforming activity
43. A region of proto-Dbl essential for its transforming activity shows sequence similarity to a yeast cell-cycle gene, Cdc24, and the human break point cluster gene, bcr
44. Crystal structure of the Dbl and Pleckstrin homology domains from the human son of sevenless protein
45. Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain
46. Human Ect2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
47. Rho GTPases and signaling networks
48. Dependence of Dbl and Dbs transformation on MEK and NF activation
49. Expression cloning of Lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C
50. Dbl family proteins
51. Guanine nucleotide exchange catalyzed by dbl oncogene product
52. Direct involvement of the small GTP-binding protein Rho in lbc oncogene function
53. The pleckstrin homology domain mediates transformation by oncogenic Dbl through specific intracellular targeting
54. Identification of Rho GTPase-dependent sites in the DH domain of oncogenic Dbl that are required for transformation
55. Oligomerization of DH domain is essential for Dbl-induced transformation