Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding

Neuron

Volumn 26, Issue 1, 2000, Pages 107-118

  Liebl, Eric C ^a   Forsthoefel, David J ^b   Franco, Lara S ^a   Sample, Sandra H ^a   Hess, Jon E ^a   Cowger, Jennifer A ^a   Chandler, Matthew P ^a   Shupert, Angela M ^a   Seeger, Mark A ^b  

^a DENISON UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GENE PRODUCT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PROTEIN TYROSINE KINASE; RAC PROTEIN; RHO FACTOR;

ARTICLE; CENTRAL NERVOUS SYSTEM; CYTOSKELETON; EMBRYO; GROWTH REGULATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 0033694911     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)81142-3     Document Type: Article

References (66)

1. Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for ena/VASP homology domain 1 (EVH1) and EVH2 domains
2. Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme
3. Drosophila: A Laboratory Handbook
4. The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension
5. The mesoderm and its derivatives
6. The guanine nucleotide exchange factor Trio mediates axonal development in the Drosophila embryo
7. The two guanine nucleotide exchange factor domains of Trio link the Rac1 and RhoA pathways in vivo
8. Molecular genetics of the Bithorax complex in Drosophila melanogaster
9. Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: Subcellular localization and mutant phenotypes imply a role in cell-cell interactions
10. Disoriented pathfinding by pioneer neuron growth cones deprived of filopodia by cytochalasin treatment
11. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
12. Requirement for integrins during Drosophila wing development
13. Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
14. Phosphorylation of enabled by the Drosophila abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of enabled
15. P-element insertion lines of essential genes on the third chromosome of Drosophila melanogaster: Correlation of physical and cytogenetic maps in chromosomal region 86E-87F
16. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains
17. Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo
18. CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium
19. Genetic analysis of a Drosophila neural cell adhesion molecule: Interaction of Fasciclin and Abelson tyrosine kinase mutations
20. Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets
21. Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance
22. Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled
23. Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog
24. Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: Prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate
25. Enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties
26. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
27. A role for Abl in Notch signaling
28. Synthetic enhancement in gene interaction: A genetic tool come of age
29. Rho GTPases and the actin cytoskeleton
30. A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila
31. Participation of small GTPases in dorsal closure of the Drosophila embryo: Distinct roles for Rho subfamily proteins in epithelial morphogenesis
32. A novel kinase-independent function of Drosophila Abl correlates with proper subcellular localization
33. Nuk controls pathfinding of commissural axons in the mammalian central nervous system
34. Genetic interactions between Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (fax), a novel protein in axon bundles
35. Drosophila abl and genetic redundancy in signal transduction
36. Midline fasciclin: A Drosophila fasciclin-I-related membrane protein localized to the CNS midline cells and trachea
37. Drosophila Rac1 controls motor axon guidance
38. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
39. Slit is the midline repellent for the Robe receptor in Drosophila
40. Essential roles for the Abl and Arg tyrosine kinases in neurulation
41. The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila
42. Mena is required for neurulation and commissure formation
43. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport
44. Genetic analysis of Fasciclin II in Drosophila: Defasciculation, refasciculation, and altered fasciculation
45. Knockouts of Src-family kinases: Stiff bones, wimpy T cells and bad memories
46. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
47. Rho family small GTP-binding proteins in growth cone signaling
48. Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction
49. Inhibition of FGF receptor activity in retinal ganglion cell axons causes errors in target recognition
50. Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo
51. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila
52. Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
53. Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes
54. Characterization and cloning of fasciclin III: A glycoprotein expressed in Drosophila
55. Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases
56. Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline
57. Trio aminoterminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth
58. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
59. Crystal structure of the Dbl and pleckstrin homology domains from the human Son of Sevenless protein
60. UNC-73 activates the rac GTPase and is required for cell growth cone migrations in C. elegans
61. Receptor tyrosine phosphatases regulate guidance across the midline of the Drosophila embryo
62. The molecular biology of axon guidance
63. The tyrosine kinase Abl and its substrate Enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
64. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
65. Inhibition of protein-tyrosine kinases impairs axon extension in the embryonic optic tract
66. Regulated tyrosine phosphorylation at the tips of growth cone filopodia