Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin

Journal of Neurochemistry

Volumn 74, Issue 6, 2000, Pages 2305-2314

  Nakamura, Ken ^a   Wright, David A ^a   Wiatr, Ted ^a   Kowlessur, Devanand ^a   Milstien, Sheldon ^b   Lei, Xin Gen ^c   Kang, Un Jung ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

Glutathione; L Buthionine S,R sulfoximine; Monochlorobimane; Parkinson's disease; Sepiapterin; Tert Butyl hydroperoxide; Tetrahydrobiopterin

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; FEMALE; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; SUBSTANTIA NIGRA; SYNTHESIS;

ANIMALS; ANTIOXIDANTS; BIOPTERIN; BUTHIONINE SULFOXIMINE; CELL SURVIVAL; DOPAMINE; ENZYME INHIBITORS; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALE; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PARKINSON DISEASE; PREGNANCY; PTERIDINES; PTERINS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; TERT-BUTYLHYDROPEROXIDE;

ANIMALIA;

EID: 0034123981     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0742305.x     Document Type: Article

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