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Volumn 13, Issue 3, 1996, Pages 259-267

Increased storage and secretion of islet amyloid polypeptide relative to insulin in the spontaneously diabetic GK rat

Author keywords

Glucose tolerance test; Goto Kakizaki rat; Immunocytochemistry; Insulin; Islet amyloid polypeptide; Plasma hormone levels

Indexed keywords

AMYLIN; GLUCOSE; INSULIN;

EID: 0029848461     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199610000-00008     Document Type: Article
Times cited : (22)

References (55)
  • 1
    • 0023025399 scopus 로고
    • A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas
    • Westermark P, Wernstedt C, Wilander E, Sletten K. A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 1986;140:827-31.
    • (1986) Biochem Biophys Res Commun , vol.140 , pp. 827-831
    • Westermark, P.1    Wernstedt, C.2    Wilander, E.3    Sletten, K.4
  • 2
    • 0023192941 scopus 로고
    • Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells
    • Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 1987;84:3881-5.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3881-3885
    • Westermark, P.1    Wernstedt, C.2    Wilander, E.3    Hayden, D.W.4    O'Brien, T.D.5    Johnson, K.H.6
  • 3
    • 0023222388 scopus 로고
    • Islet amyloid in type 2 diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone
    • Westermark P, Wernstedt C, O'Brien TD, Hayden DW, Johnson KH. Islet amyloid in type 2 diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Am J Pathol 1987;127:414-7.
    • (1987) Am J Pathol , vol.127 , pp. 414-417
    • Westermark, P.1    Wernstedt, C.2    O'Brien, T.D.3    Hayden, D.W.4    Johnson, K.H.5
  • 5
    • 0024834967 scopus 로고
    • Secretion of islet amyloid polypeptide in response to glucose
    • Kanatsuka A, Makino H, Ohsawa H, et al. Secretion of islet amyloid polypeptide in response to glucose. FEBS Lett 1989;259:199-201.
    • (1989) FEBS Lett , vol.259 , pp. 199-201
    • Kanatsuka, A.1    Makino, H.2    Ohsawa, H.3
  • 6
    • 0025255102 scopus 로고
    • Cosecretion of amylin and insulin from isolated rat pancreas
    • Fehmann HC, Weber V, Göke R, Göke B, Arnold R. Cosecretion of amylin and insulin from isolated rat pancreas. FEBS Lett 1990;262:279-81.
    • (1990) FEBS Lett , vol.262 , pp. 279-281
    • Fehmann, H.C.1    Weber, V.2    Göke, R.3    Göke, B.4    Arnold, R.5
  • 7
    • 0025302287 scopus 로고
    • Evidence of cosecretion of islet amyloid polypeptide and insulin by β-cells
    • Kahn SE, D'Alessio DD, Schwartz MW, et al. Evidence of cosecretion of islet amyloid polypeptide and insulin by β-cells. Diabetes 1990;39:634-8.
    • (1990) Diabetes , vol.39 , pp. 634-638
    • Kahn, S.E.1    D'Alessio, D.D.2    Schwartz, M.W.3
  • 8
    • 0025957988 scopus 로고
    • Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans
    • Hartter E, Svoboda T, Ludvik B, et al. Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans. Diabetologia 1991;32:52-4.
    • (1991) Diabetologia , vol.32 , pp. 52-54
    • Hartter, E.1    Svoboda, T.2    Ludvik, B.3
  • 9
    • 0025309015 scopus 로고
    • Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation
    • Nakazato M, Miyazato M, Asai J, et al. Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation. Biochem Biophys Res Commun 1990;169:713-8.
    • (1990) Biochem Biophys Res Commun , vol.169 , pp. 713-718
    • Nakazato, M.1    Miyazato, M.2    Asai, J.3
  • 10
    • 0026770604 scopus 로고
    • Relative hypersecretion of amylin to insulin from rat pancreas after neonatal STZ treatment
    • Inoue K, Hisatomi A, Umeda F, Nawata H. Relative hypersecretion of amylin to insulin from rat pancreas after neonatal STZ treatment. Diabetes 1992;41:723-7.
    • (1992) Diabetes , vol.41 , pp. 723-727
    • Inoue, K.1    Hisatomi, A.2    Umeda, F.3    Nawata, H.4
  • 11
    • 0025967810 scopus 로고
    • Plasma islet amyloid polypeptide (amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients
    • Sanke T, Hanabusa T, Nakano Y, et al. Plasma islet amyloid polypeptide (amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1991;34:129-32.
    • (1991) Diabetologia , vol.34 , pp. 129-132
    • Sanke, T.1    Hanabusa, T.2    Nakano, Y.3
  • 12
    • 0025348798 scopus 로고
    • The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm
    • Hothersall JS, Muirhead RP, Wimalawansa S. The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm. Biochem Biophys Res Commun 1990;169:451-4.
    • (1990) Biochem Biophys Res Commun , vol.169 , pp. 451-454
    • Hothersall, J.S.1    Muirhead, R.P.2    Wimalawansa, S.3
  • 13
    • 0026575033 scopus 로고
    • Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol esterstimulated glucose transport in in vitro incubated human muscle strips
    • Zierath JR, Galuska D, Engström Å, et al. Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol esterstimulated glucose transport in in vitro incubated human muscle strips. Diabetologia 1992;35:26-31.
    • (1992) Diabetologia , vol.35 , pp. 26-31
    • Zierath, J.R.1    Galuska, D.2    Engström, Å.3
  • 14
    • 0025811117 scopus 로고
    • In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle
    • Frontoni S, Bong Choi S, Banduch D, Rossetti L. In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle. Diabetes 1991;40:568-73.
    • (1991) Diabetes , vol.40 , pp. 568-573
    • Frontoni, S.1    Bong Choi, S.2    Banduch, D.3    Rossetti, L.4
  • 15
    • 0026089912 scopus 로고
    • Amylin activates glycogen phosphorylase and inactivates glycogen synthase via a cAMP-independent mechanism
    • Deems RO, Deacon RW, Young DA. Amylin activates glycogen phosphorylase and inactivates glycogen synthase via a cAMP-independent mechanism. Biochem Biophys Res Commun 1991;174:716-20.
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 716-720
    • Deems, R.O.1    Deacon, R.W.2    Young, D.A.3
  • 16
    • 0026083066 scopus 로고
    • Amylin activates glycogen phosphorylase in the isolated soleus muscle of the rat
    • Young AA, Mott DM, Stone K, Cooper GJS. Amylin activates glycogen phosphorylase in the isolated soleus muscle of the rat. FEBS Lett 1991;281:149-51.
    • (1991) FEBS Lett , vol.281 , pp. 149-151
    • Young, A.A.1    Mott, D.M.2    Stone, K.3    Cooper, G.J.S.4
  • 17
    • 0026110135 scopus 로고
    • β-cells in type II diabetes mellitus
    • Porte D Jr. β-cells in type II diabetes mellitus. Diabetes 1991;40:166-80.
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 18
    • 0028354142 scopus 로고
    • Amylin compared with calcitonin gene-related peptide: Structure, biology, and relevance to metabolic disease
    • Cooper GJS. Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease. Endocr Rev 1994;15:163-201.
    • (1994) Endocr Rev , vol.15 , pp. 163-201
    • Cooper, G.J.S.1
  • 19
    • 0027104852 scopus 로고
    • Homologous islet amyloid polypeptide: Effects on plasma levels of glucagon, insulin and glucose in the mouse
    • Panagiotidis G, Salchi AA, Westermark P, Lundquist I. Homologous islet amyloid polypeptide: effects on plasma levels of glucagon, insulin and glucose in the mouse. Diab Res Clin Pract 1992;18:167-71.
    • (1992) Diab Res Clin Pract , vol.18 , pp. 167-171
    • Panagiotidis, G.1    Salchi, A.A.2    Westermark, P.3    Lundquist, I.4
  • 20
    • 0013410806 scopus 로고
    • The nature of the stimulus determines the effects of IAPP on islet hormone release
    • Åkesson B, Panagiotidis G, Westermark P, Lundquist I. The nature of the stimulus determines the effects of IAPP on islet hormone release. Pharmacol Toxicol 1995;suppl IV:76.
    • (1995) Pharmacol Toxicol , Issue.4 SUPPL. , pp. 76
    • Åkesson, B.1    Panagiotidis, G.2    Westermark, P.3    Lundquist, I.4
  • 22
    • 0025217027 scopus 로고
    • Islet amyloid polypeptide. A new β-cell secretory product related to islet amyloid deposits
    • Nishi M, Sanke T, Nagamatsu S, Bell GI, Steiner DF. Islet amyloid polypeptide. A new β-cell secretory product related to islet amyloid deposits. J Biol Chem 1990;265:4173-6.
    • (1990) J Biol Chem , vol.265 , pp. 4173-4176
    • Nishi, M.1    Sanke, T.2    Nagamatsu, S.3    Bell, G.I.4    Steiner, D.F.5
  • 24
    • 0026595151 scopus 로고
    • Islet amyloid polypeptide plasma concentrations in individuals at increased risk of developing Type 2 (non-insulin-dependent) diabetes mellitus
    • Eriksson J, Nakazato M, Miyazato M, Shiomi K, Matsukura S, Groop L. Islet amyloid polypeptide plasma concentrations in individuals at increased risk of developing Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992;35:291-3.
    • (1992) Diabetologia , vol.35 , pp. 291-293
    • Eriksson, J.1    Nakazato, M.2    Miyazato, M.3    Shiomi, K.4    Matsukura, S.5    Groop, L.6
  • 25
    • 0027096266 scopus 로고
    • The etiology and pathogenesis of non-insulin-dependent diabetes
    • Groop LC, Eriksson JG. The etiology and pathogenesis of non-insulin-dependent diabetes. Ann Med 1992;24:483-9.
    • (1992) Ann Med , vol.24 , pp. 483-489
    • Groop, L.C.1    Eriksson, J.G.2
  • 26
    • 0026599843 scopus 로고
    • Possible links between amylin and diabetes
    • Luskey KL. Possible links between amylin and diabetes. Diabetes Care 1992;41:297-9.
    • (1992) Diabetes Care , vol.41 , pp. 297-299
    • Luskey, K.L.1
  • 28
    • 0027394007 scopus 로고
    • Non-insulin dependent diabetes mellitus: Defects in insulin secretion
    • Wolffenbuttel BHR, Van Haeften TW. Non-insulin dependent diabetes mellitus: defects in insulin secretion. Eur J Clin Invest 1993;23:69-79.
    • (1993) Eur J Clin Invest , vol.23 , pp. 69-79
    • Wolffenbuttel, B.H.R.1    Van Haeften, T.W.2
  • 30
    • 0000916866 scopus 로고
    • GK rat as a model of nonobese, noninsulin-dependent diabetes: Selective breeding over 35 generations
    • Schafrir E, Renold AE, eds. London: John Libbey
    • Goto Y, Suzuki K, Sasaki M, Ono T, Abe S. GK rat as a model of nonobese, noninsulin-dependent diabetes: selective breeding over 35 generations. In: Schafrir E, Renold AE, eds. Frontiers in diabetes research. Lessons from animal diabetes II. London: John Libbey, 1988:301-3.
    • (1988) Frontiers in Diabetes Research. Lessons from Animal Diabetes II , pp. 301-303
    • Goto, Y.1    Suzuki, K.2    Sasaki, M.3    Ono, T.4    Abe, S.5
  • 31
    • 0025877358 scopus 로고
    • β-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes
    • Portha B, Serradas P, Bailbe D, Suzuki K, Goto Y, Giroix M. β-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes. Diabetes 1991;40: 486-91.
    • (1991) Diabetes , vol.40 , pp. 486-491
    • Portha, B.1    Serradas, P.2    Bailbe, D.3    Suzuki, K.4    Goto, Y.5    Giroix, M.6
  • 32
    • 0027339801 scopus 로고
    • Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat
    • Östenson C-G, Khan A, Abdel-Halim SM, et al. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 1993; 36:3-8.
    • (1993) Diabetologia , vol.36 , pp. 3-8
    • Östenson, C.-G.1    Khan, A.2    Abdel-Halim, S.M.3
  • 33
    • 3743137502 scopus 로고
    • Spontaneous diabetes produced by repeated selective breeding of normal Wistar rats
    • Bajaj JS, ed. Amsterdam: Excerpta Medica
    • Goto Y, Kakizaki M, Toyota T, et al. Spontaneous diabetes produced by repeated selective breeding of normal Wistar rats. In: Bajaj JS, ed. Diabetes. Amsterdam: Excerpta Medica, 1977:703-10.
    • (1977) Diabetes , pp. 703-710
    • Goto, Y.1    Kakizaki, M.2    Toyota, T.3
  • 34
    • 0028146630 scopus 로고
    • The role of islet secretory function in the development of diabetes in the GK Wistar rat
    • Hughes SJ, Suzuki K, Goto Y. The role of islet secretory function in the development of diabetes in the GK Wistar rat. Diabetologia 1994;37:863-70.
    • (1994) Diabetologia , vol.37 , pp. 863-870
    • Hughes, S.J.1    Suzuki, K.2    Goto, Y.3
  • 35
    • 0027193976 scopus 로고
    • GLUT2 expression and function in β-cells of GK rats with NIDDM
    • Ohneda M, Johnson JH, Inman LR, et al. GLUT2 expression and function in β-cells of GK rats with NIDDM. Diabetes 1993;42:1065-72.
    • (1993) Diabetes , vol.42 , pp. 1065-1072
    • Ohneda, M.1    Johnson, J.H.2    Inman, L.R.3
  • 36
    • 0027392911 scopus 로고
    • Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes
    • Giroix M, Vesco L, Portha B. Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes. Endocrinology 1993;132:815-22.
    • (1993) Endocrinology , vol.132 , pp. 815-822
    • Giroix, M.1    Vesco, L.2    Portha, B.3
  • 37
  • 38
    • 85004203055 scopus 로고
    • The spontaneous-diabetic rat: A model of noninsulin dependent diabetes mellitus
    • Goto Y, Kakizaki M. The spontaneous-diabetic rat: a model of noninsulin dependent diabetes mellitus. Proc Jpn Acad 1981;57:381-4.
    • (1981) Proc Jpn Acad , vol.57 , pp. 381-384
    • Goto, Y.1    Kakizaki, M.2
  • 39
    • 0000785611 scopus 로고
    • The unlabelled antibody peroxidase-antiperoxidase (PAP) method
    • Sternberger LA, ed. New York: Wiley
    • Sternberger LA. The unlabelled antibody peroxidase-antiperoxidase (PAP) method. In: Sternberger LA, ed. Immunohistochemistry. New York: Wiley, 1979:104-67.
    • (1979) Immunohistochemistry , pp. 104-167
    • Sternberger, L.A.1
  • 40
    • 0027453151 scopus 로고
    • Islet amyloid polypeptide in the rabbit and European hare: Studies on its relationship to amyloidogenesis
    • Christmanson L, Betsholtz C, Leckström A, et al. Islet amyloid polypeptide in the rabbit and European hare: studies on its relationship to amyloidogenesis. Diabetologia 1993;36: 183-8.
    • (1993) Diabetologia , vol.36 , pp. 183-188
    • Christmanson, L.1    Betsholtz, C.2    Leckström, A.3
  • 41
    • 0020569676 scopus 로고
    • Islet amyloid in type 2 (non-insulin-dependent) diabetes is related to insulin
    • Westermark P, Wilander E. Islet amyloid in type 2 (non-insulin-dependent) diabetes is related to insulin. Diabetologia 1983;24:342-6.
    • (1983) Diabetologia , vol.24 , pp. 342-346
    • Westermark, P.1    Wilander, E.2
  • 43
    • 0004058537 scopus 로고
    • Qualitative pancreatic changes in diabetes mellitus. Fibrosis
    • Warren S, LeCompte PM, Legg MA, eds. Philadelphia: Lea & Febiger
    • Warren S, LeCompte PM, Legg MA. Qualitative pancreatic changes in diabetes mellitus. Fibrosis. In: Warren S, LeCompte PM, Legg MA, eds. The pathology of diabetes mellitus. Philadelphia: Lea & Febiger, 1966:64-5.
    • (1966) The Pathology of Diabetes Mellitus , pp. 64-65
    • Warren, S.1    LeCompte, P.M.2    Legg, M.A.3
  • 44
    • 0027246174 scopus 로고
    • Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin-dependent diabetic GK (Goto-Kakizaki) rats
    • Abdel-Halim SM, Guenifi A, Efendic S, Östenson C-G. Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin-dependent diabetic GK (Goto-Kakizaki) rats. Acta Physiol Scand 1993;148:219-26.
    • (1993) Acta Physiol Scand , vol.148 , pp. 219-226
    • Abdel-Halim, S.M.1    Guenifi, A.2    Efendic, S.3    Östenson, C.-G.4
  • 45
    • 0027220316 scopus 로고
    • Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats
    • Östenson C-G, Abdel-Halim SM, Rasschaert J, et al. Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats. Diabetologia 1993;36:722-6.
    • (1993) Diabetologia , vol.36 , pp. 722-726
    • Östenson, C.-G.1    Abdel-Halim, S.M.2    Rasschaert, J.3
  • 46
    • 0006926807 scopus 로고
    • Non-insulin dependent diabetes mellitus in GK rats
    • Suzuki K, Goto Y. Non-insulin dependent diabetes mellitus in GK rats. Prog Diab Mell Res 1987;22:211-7.
    • (1987) Prog Diab Mell Res , vol.22 , pp. 211-217
    • Suzuki, K.1    Goto, Y.2
  • 47
    • 0025042084 scopus 로고
    • Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin
    • Jamal H, Bretherton-Watt D, Suda K, Ghatei MA, Bloom SR. Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin. J Endocrinol 1990;126:425-9.
    • (1990) J Endocrinol , vol.126 , pp. 425-429
    • Jamal, H.1    Bretherton-Watt, D.2    Suda, K.3    Ghatei, M.A.4    Bloom, S.R.5
  • 48
    • 0027242013 scopus 로고
    • Cosecretion of islet amyloid polypeptide (IAPP) and insulin from isolated rat pancreatic islets following stimulation or inhibition of β-cell function
    • Stridsberg M, Sandler S, Wilander E. Cosecretion of islet amyloid polypeptide (IAPP) and insulin from isolated rat pancreatic islets following stimulation or inhibition of β-cell function. Regul Pept 1993;45:363-70.
    • (1993) Regul Pept , vol.45 , pp. 363-370
    • Stridsberg, M.1    Sandler, S.2    Wilander, E.3
  • 49
    • 0028356948 scopus 로고
    • Insulin treatment improves relative hypersecretion of amylin to insulin in rats with noninsulin-dependent diabetes mellitus induced by neonatal sreptozocin injection
    • Hiramatsu S, Inoue K, Sako Y, Umeda F, Nawata H. Insulin treatment improves relative hypersecretion of amylin to insulin in rats with noninsulin-dependent diabetes mellitus induced by neonatal sreptozocin injection. Metabolism 1994;43:766-70.
    • (1994) Metabolism , vol.43 , pp. 766-770
    • Hiramatsu, S.1    Inoue, K.2    Sako, Y.3    Umeda, F.4    Nawata, H.5
  • 50
    • 0028079090 scopus 로고
    • Direct plasma radioimmunoassay for rat amylin-(1-37): Concentrations with acquired and genetic obesity
    • Pieber TR, Roitelman J, Lee Y, Luskey KL, Stein DT. Direct plasma radioimmunoassay for rat amylin-(1-37): concentrations with acquired and genetic obesity. Am J Physiol 1994;267:E156-64.
    • (1994) Am J Physiol , vol.267
    • Pieber, T.R.1    Roitelman, J.2    Lee, Y.3    Luskey, K.L.4    Stein, D.T.5
  • 51
    • 0027162775 scopus 로고
    • Hypersecretion of amylin from the perfused pancreas of genetically obese (fa/fa) rats and its alteration with aging
    • Inoue K, Hiramatsu S, Hisatomi A, Umeda F, Nawata H. Hypersecretion of amylin from the perfused pancreas of genetically obese (fa/fa) rats and its alteration with aging. Metabolism 1993;42:654-8.
    • (1993) Metabolism , vol.42 , pp. 654-658
    • Inoue, K.1    Hiramatsu, S.2    Hisatomi, A.3    Umeda, F.4    Nawata, H.5
  • 52
    • 0027493026 scopus 로고
    • Insulin resistance in the GK rat: Decreased receptor number but normal kinase activity in liver
    • Bisbis S, Bailbe D, Tormo M-A, et al. Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver. Am J Physiol 1993;265:E807-13.
    • (1993) Am J Physiol , vol.265
    • Bisbis, S.1    Bailbe, D.2    Tormo, M.-A.3
  • 53
    • 0025054691 scopus 로고
    • Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas
    • Silvestre RA, Peiró E, Dégano P, Miralles P, Marco J. Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas. Regul Pept 1990;31:23-31.
    • (1990) Regul Pept , vol.31 , pp. 23-31
    • Silvestre, R.A.1    Peiró, E.2    Dégano, P.3    Miralles, P.4    Marco, J.5
  • 54
    • 0025764548 scopus 로고
    • Inhibitory action of islet amyloid polypeptide and calcitonin gene-related peptide on release of insulin from the isolated rat pancreas
    • Kogire M, Ishizuka J, Thompson JC, Greeley Jr GH. Inhibitory action of islet amyloid polypeptide and calcitonin gene-related peptide on release of insulin from the isolated rat pancreas. Pancreas 1991;6:459-63.
    • (1991) Pancreas , vol.6 , pp. 459-463
    • Kogire, M.1    Ishizuka, J.2    Thompson, J.C.3    Greeley Jr., G.H.4
  • 55
    • 0028205298 scopus 로고
    • Amylin/insulin secretory ratios in morbidly obese man: Inverse relationship with glucose disappearance rate
    • Blackard WG, Clore JN, Kellum JM. Amylin/insulin secretory ratios in morbidly obese man: inverse relationship with glucose disappearance rate. J Clin Endocrinol Metab 1994; 78:1257-60.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1257-1260
    • Blackard, W.G.1    Clore, J.N.2    Kellum, J.M.3


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