Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'- deoxycytidine 5'-diphosphate: A paradigm for nucleotide mechanism-based inhibitors

Biochemistry

Volumn 35, Issue 25, 1996, Pages 8381-8391

  Van der Donk, Wilfred A ^a   Yu, Guixue ^a,c   Silva, Domingos J ^a   Stubbe, Joanne ^a   McCarthy, James R ^b,d   Jarvi, Esa T ^b   Matthews, Donald P ^b   Resvick, Robert J ^b   Wagner, Eugene ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Merrell Dow Research Institute   (United States)

^c CUBIST PHARMACEUTICALS INC   (United States)

^d NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' FLUOROMETHYLENE 2' DEOXYCYTIDINE 5' DIPHOSPHATE; CARBON 14; ENZYME INHIBITOR; NUCLEOSIDE ANALOG; RIBONUCLEOTIDE REDUCTASE; TRITIUM; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CATALYSIS; CYTOTOXICITY; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME INACTIVATION; ESCHERICHIA COLI; ISOTOPE LABELING; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL;

ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DEOXYCYTOSINE NUCLEOTIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; ESCHERICHIA COLI; ISOMERISM; KINETICS; MICE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; PIGMENTS, BIOLOGICAL; RIBONUCLEOTIDE REDUCTASES;

ESCHERICHIA COLI; TRITIUM;

EID: 0030036601     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960190j     Document Type: Article

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