Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: Structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins

Biochemistry

Volumn 37, Issue 30, 1998, Pages 10798-10807

  Logan, Derek T ^a   DeMaré, Fredrick ^a,b   Persson, Bert O ^a   Slaby, Agneta ^a   Sjöberg, Britt Marie ^a   Nordlund, Pär ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b Biotechnology/Expression   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ELECTRON TRANSPORT; HYDROXYLATION; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS;

ALANINE; APOENZYMES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FERROUS COMPOUNDS; GLUTAMIC ACID; HYDROXYLATION; IRON; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXYGEN; PHENYLALANINE; RIBONUCLEOTIDE REDUCTASES; TYROSINE;

EID: 0032575296     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9806403     Document Type: Article

References (56)

1. Nordlund, P., and Eklund, H. (1996) Curr. Opin. Struct. Biol. 5, 758-766.
2. Nordlund, P., Sjöberg, B.-M., and Eklund, H. (1990) Nature 345, 593-598.
3. Fontecave, M., Nordlund, P., Eklund, H., and Reichard, P. (1992) Adv. Enzymol. Relat. Areas Mol. Biol. 65, 147-183.
4. Sjöberg, B. M. (1997) Struct. and Bonding 88, 139-173.
5. Rosenzweig, A. C., Frederick, C. A., Lippard, S. J., and Nordlund, P. (1993) Nature 366, 537-543.
6. Lipscomb, J. D. (1994) Annu. Rev. Microbiol. 48, 371-399.
7. Lindqvist, Y., Huang, W., Schneider, G., and Shanklin, J. (1996) EMBO J. 15, 4081-4092.
8. Frolow, F., Kalb(Gilboa), J., and Yariv, J. (1994) Nat. Struct. Biol. 1, 453-460.
9. deMaré, F., Kurtz, D. M. J., and Nordlund, P. (1996) Nat. Struct. Biol. 3, 539-546.
10. Stenkamp, R. E. (1994) Chem. Rev. 94, 715-726.
11. Sträter, N., Klabunde, T., Tucker, P., Witzel, H., and Krebs, B. (1995) Science 268, 1489-1492.
12. Ling, J. S., Sahlin, M., Sjöberg, B. M., Loehr, T. M., and Sanders-Loehr, J. (1994) J. Biol. Chem. 269, 5595-5601.
13. Sahlin, M., Lassmann, G., Pötsch, S., Sjöberg, B. M., and Gräslund, A. (1995) J. Biol. Chem. 270, 12361-12372.
14. Katterle, B., Sahlin, M., Schmidt, P. P., Pötsch, S., Logan, D., Gräslund, A., and Sjöberg, B. M. (1997) J. Biol. Chem. 272, 10414-10421.
15. Logan, D. T., Su, X.-D., Åberg, A., Regnström, K., Hajdu, J., Eklund, H., and Nordlund, P. (1996) Structure 4, 1053-1064.
16. Ormö, M., deMaré, F., Regnström, K., Åberg, A., Sahlin, M., Ling, J., Loehr, T. M., Sanders-Loehr, J., and Sjöberg, B. M. (1992) J. Biol. Chem. 267, 8711-8714.
17. Åberg, A., Ormö, M., Nordlund, P., and Sjöberg, B. M. (1993) Biochemistry 32, 9845-9850.
18. Klinman, J. P., and Mu, D. (1994) Annu. Rev. Biochem. 63, 299-344.
19. Hartmann, C., and McIntire, W. S. (1997) Methods Enzymol. 280, 98-150.
20. Sturgeon, B. E., Burdi, D., Chen, S., Huynh, B.-H., Edmondson, D. E., Stubbe, J., and Hoffman B. M. (1997) J. Am. Chem. Soc. 118, 7551-7551.
21. Rosenzweig, A. C., Nordlund, P., Takahara, P. M., Frederick, C. A., and Lippard, S. J. (1995) Chem. Biol. 2, 409-418.
22. Rosenzweig, A. C., Fredrick, C. A., and Lippard, S. J. (1996) in Microbial Growth on C1 Compounds: proceedings of the 8th International Symposium on Microbial Growth on C1 Compounds (Lidstrom, M. E., and Tabita, F. R., Eds.) 141-149, Kluwer, Dordrecht, The Netherlands.
23. Persson, B. O., Karlsson, M., Climent, I., Ling, J. S., Sanders-Loehr, J., Sahlin, M., and Sjöberg, B. M. (1996) J. Biol. Inorg. Chem. 1, 247-256.
24. Nordlund, P., Uhlin, U., Westergren, C., Joelsen, T., Sjöberg, B. M., and Eklund, H. (1989) FEBS Lett. 258, 251-254.
25. Otwinowski, Z. (1993) in Data collection and Processing. Proceedings of the CCP4 study weekend. 56-62, SERC Daresbury Laboratory, Warrington, U.K.
26. French, S., and Wilson, K. S. (1974) Acta Crystallogr. A34, 517-523.
27. Wilson, A. J. C. (1949) Acta Crystallogr. 2, 318-321.
28. Tronrud, D. E., ten Eyck, L. F., and Matthews, B. W. (1987) Acta Crystallogr. A43, 481-501.
29. Tronrud, D. E. (1992) Acta Crystallogr. A48, 912-916.
30. Brünger, A. (1992) Nature 555, 472-475.
31. Collaborative Computational Project, no. 4 (1994) Acta Crystallogr. D50, 760-763.
32. Nordlund, P., and Eklund, H. (1993) J. Mol. Biol. 232, 123-164.
33. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. A47, 392-400.
34. Åberg, A. (1993) Ph.D. Thesis, Stockholm University.
35. Aria, M., Nordlund, P., Åberg, A., Eklund, H., and Fontecave, M. (1992) J. Biol. Chem. 267, 20682-20688.
36. Åberg, A., Nordlund, P., and Eklund, H. (1993) Nature 361, 276-278.
37. Su, X.-D. (1994) Ph.D. Thesis, Stockholm University.
38. Andersson, K. K., and Gräslund, A. (1995) Adv. Inorg. Chem. 43, 359-408.
39. Andersson, K. K., Elgren, T. E., Que, L. J., and Lipscomb, J. D. (1992) J. Am. Chem. Soc. 114, 8711-8713.
40. Ek-Rylander, B., Barkhem, T., Ljusberg, J., Öhman, L., Andersson, K. K., and Andersson, G. (1997) Biochem. J. 321, 305-311.
41. Dietrich, M., Münstermann, D., Suerbaum, H., and Witzel, H. (1991) Eur. J. Biochem. 199, 105-113.
42. Suerbaum, H., Körner, M., Witzel, H., Althaus, E., Mösel, B. D., and Muller-Warmuth, W. (1993) Eur. J. Biochem. 214, 313-321.
43. Parkin, S. E., Chen, S., Ley, B. A., Mangravite, L., Edmondson, D. E., Huynh, B.-H., and Bollinger, J. M., Jr. (1998) Biochemistry 37, 1124-1130.
44. Siegbahn, P., and Crabtree, R. H. (1997) J. Am. Chem. Soc. 119, 3103-3113.
45. Isied, S. S. (1994) in Metal ions in biological systems (Sigel, H., and Sigel, A., Eds.) 1-50, Marcel Dekker, Inc., New York.
46. Nam, W. W., and Valentine, J. S. (1993) J. Am. Chem. Soc. 115, 1772-1778.
47. Bollinger, J. M., Jr., Tong, W. H., Ravi, N., Huynh, B. H., Edmondson, D. E., and Stubbe, J. (1994) J. Am. Chem. Soc. 116, 8015-8023.
48. Valentine, A. M., Tavares, P., Pereira, A. S., Davydov, R., Krebs, C., Hoffmann, B. M., Edmondson, D. E., Huynh, B. H., and Lippard, S. J. (1998) J. Am. Chem. Soc. 120, 2190-2191.
49. Bollinger, J. M., Jr., Chen, S., Parkin, S. E., Mangravite, L. A., Ley, B. A., Edmondson, D. E., and Huynh, B. H. (1997) J. Am. Chem. Soc. 119, 5976-5977.
50. Riggs-Gelasco, P. J., Shu, L., Chen, S., Burdi, D., Huynh, B. H., Que, L., Jr., and Stubbe, J. (1998) J. Am. Chem. Soc. 120, 849-860.
51. Morris A. L., MacArthur M. W., Hutchinson E. G., and Thornton J. M. (1992) Proteins 12, 345-364.
52. Esnouf, R. M. (1997) J. Mol. Graphics 15, 133-138.
53. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
54. Bacon, D. J., and Anderson, W. F. (1988) J. Mol. Graphics 6, 219-220.
55. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. D50, 869-873.
56. Liu, A., Sahlin, M., Pötsch, S., Sjöberg, B. M., and Gräslund, A. (1998) Biochem. Biophys. Res. Commun. 246, 740-745.