Neuroprotective adaptations in hibernation: Therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases

Free Radical Biology and Medicine

Volumn 31, Issue 5, 2001, Pages 563-573

  Drew, Kelly L ^a   Rice, Margaret E ^b   Kuhn, Thomas B ^a   Smith, Mark A ^c  

^a UNIVERSITY OF ALASKA FAIRBANKS   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer disease; Antioxidants; Arctic ground squirrel; Free radicals; Metabolic suppression; Oxidative stress; Stroke

Indexed keywords

ASCORBIC ACID; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; BLOOD CLOTTING DISORDER; BRAIN INJURY; BRAIN ISCHEMIA; DEGENERATIVE DISEASE; HIBERNATION; HUMAN; HYPOTHERMIA; IMMUNOSUPPRESSIVE TREATMENT; LEUKOPENIA; METABOLIC INHIBITION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES DIFFERENCE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BRAIN; BRAIN INJURIES; HIBERNATION; HUMANS; NEURODEGENERATIVE DISEASES; REPERFUSION INJURY;

EID: 0035451524     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00628-1     Document Type: Review

References (151)

1. Physiology of hibernation in mammals
2. Freeze avoidance in a mammal: Body temperatures below 0 degrees C in an Arctic hibernator
3. Molecular and metabolic aspects of mammalian hibernation
4. Effects of ambient temperature on metabolic rate, respiratory quotient, and torpor in an arctic hibernator
5. Dynamics of ascorbate regulation during hibernation and arousal in arctic ground squirrels
6. Local cerebral blood flow during hibernation, a model of natural tolerance to "cerebral ischemia"
7. Neuroprotective strategies in nature - Novel clues for the treatment of stroke and trauma
8. The mechanisms of hypoxic tolerance in hibernating and non-hibernating mammals
9. Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia: An in vitro study in hippocampal slices
10. Hibernation, a model of neuroprotection
11. Gluconeogenesis in arctic ground squirrels between periods of hibernation
12. The temporal organization of daily torpor and hibernation: Circadian and circannual rhythms
13. The histaminergic system in the brain: Structural characteristics and changes in hibernation
14. Gene expression in the brain across the hibernation cycle
15. Dissimilarity of slow-wave activity enhancement by torpor and sleep deprivation in a hibernator
16. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury
17. Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia
18. Treatment of traumatic brain injury with moderate hypothermia
19. Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia
20. Lack of effect of induction of hypothermia after acute brain injury
21. Hypothermia-associated protection from ischemic brain injury: Implications for patient management
22. Regulation of body temperature and energy requirements of hibernating alpine marmots (Marmota marmota)
23. Hibernation: Cellular aspects
24. Prolonged stable hypothermia: Effect on blood gases and pH in rats and ground squirrels
25. Elevating intracellular free Mg2+ preserves sensitivity of Na(+)-K+ pump to ATP at reduced temperatures in guinea pig red blood cells
26. Oxidative stress in brain ischemia
27. Characterization of plasma magnesium concentration and oxidative stress following graded traumatic brain injury in humans
28. Oxidative stress in Alzheimer disease
29. Oxidative stress, mitochondrial respiration, and Parkinson's disease
30. Redox-active iron mediates amyloid-β toxicity
31. Oxidative damage in Alzheimer's
32. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
33. Immunohistochemical evidence of oxidative stress in Alzheimer's disease
34. Advanced Maillard reaction end products are associated with Alzheimer disease pathology
35. Activation of p38 pathway links tau phosphorylation, oxidative stress and cell cycle related events in Alzheimer disease
36. Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease
37. Oxidative stress in closed-head injury: Brain antioxidant capacity as an indicator of functional outcome
38. Levels of low molecular weight scavengers in the rat brain during focal ischemia
39. Ascorbate and glutathione regulation in hibernating ground squirrels
40. Ascorbate regulation and its neuroprotective role in the brain
41. Xanthine oxidase in biology and medicine
42. Antioxidant defenses in the ground squirrel Citellus citellus. 2. The effect of hibernation
43. Seasonal variation in the antioxidant defense system of the brain of the ground squirrel (Citellus citellus) and response to low temperature compared with rat
44. Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke
45. Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer's disease
46. Ischemia/reperfusion-induced injury of forebrain mitochondria and protection from ascorbate
47. Neuroprotection by 2-h postischemia administration of two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia
48. Review of oxidative stress in brain and spinal cord injury: Suggestions for pharmacological and nutritional management strategies
49. N-acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats
50. Ascorbic acid and focal cerebral ischaemia in a primate model
51. A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease
52. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study
53. Reactive oxygen radicals in signaling and damage in the ischemic brain
54. Three-dimensional metabolic and hemodynamic imaging of the normal and ischemic rat brain
55. Metabolism in the hamster brain during hibernation and arousal
56. Metabolic regulation in mammalian hibernation: Enzyme and protein adaptations
57. Defense strategies against hypoxia and hypothermia
58. Adaptations of vertebrate neurons to hypoxia and anoxia: Maintaining critical Ca2+ concentrations
59. Acute reduction in whole cell conductance in anoxic turtle brain
60. Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons
61. Repeated changes of dendritic morphology in the hippocampus of ground squirrels in the course of hibernation
62. Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation
63. mRNA stability and polysome loss in hibernating arctic ground squirrels (Spermophilus parryii)
64. Downregulation of sodium channels during anoxia: A putative survival strategy of turtle brain
65. Adenosine and anoxia reduce N-methyl-D-aspartate receptor open probability in turtle cerebrocortex
66. Hypoxia-induced silencing of NMDA receptors in turtle neurons
67. Metabolic adaptations of hibernators
68. The oxygen consumption and temperature regulation of hibernating hamsters
69. Hibernation induced in ground squirrels by blood transfusion
70. Absence of evidence for a hibernation "trigger" in blood dialyzate of Richardson's ground squirrel
71. Failure to initiate hibernation with blood from the hibernating arctic ground squirrel, Citellus undulatus, and Eastern woodchuck, Marmota monax
72. Induction of summer hibernation in the 13-lined ground squirrel shown by comparative serum transfusions from arctic mammals
73. The "hibernation induction trigger": Specificity and validity of bioassay using the 13-lined ground squirrel
74. Hibernation triggers and cryogens: Do they play a role in hibernation?
75. Isolation and partial characterization of an opioid-like 88 kDa hibernation-related protein
76. Delta opioid peptide [D-Ala(2),D-Leu(5)]enkephalin promotes cell survival
77. Further studies on opioids and hibernation: Delta opioid receptor ligand selectively induced hibernation in summer-active ground squirrels
78. Antimetabolic extract from the brain of the hibernating ground squirrel Citellus tridecemlineatus
79. Anti-metabolic extract from the brain of Protopterus aethiopicus
80. Central role for differential gene expression in mammalian hibernation
81. Stimulation of tyrosine phosphorylation of a brain protein by hibernation
82. Effect of isoproterenol on the L-type Ca2+ current in cardiac cells from rats and hibernating ground squirrels
83. Regulation of ground squirrel Na+K+-ATPase activity by reversible phosphorylation during hibernation
84. Gene up-regulation in heart during mammalian hibernation
85. Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal
86. Hibernation: Neural aspects
87. Properties of the CNS during the state of hibernation
88. The study of brain slices from hibernating mammals in vitro and some approaches to the analysis of hibernation problems in vivo
89. Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation
90. The suprachiasmatic nucleus: A 25-year retrospective
91. [14C]2-deoxyglucose uptake in ground squirrel brain during hibernation
92. C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation
93. Ultrastructure of the hypothalamic neurosecretory nuclei of the dormouse (Eliomys quercinus L.) in the awakening and hibernating states
94. Cellular response to penetrating CNS injury
95. Advances in the vascular pathophysiology of ischemic stroke
96. Neuroinflammatory responses in the Alzheimer's disease brain promote the oxidative post-translational modification of amyloid deposits
97. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period
98. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1
99. Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia
100. Cerebral ischemia: The no-reflow phenomenon
101. Role of neutrophils in ischemia-perfusion-induced microvascular injury
102. Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model
103. Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat
104. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat
105. Polymorphonuclear leukocytes and microcirculatory perfusion in acute stroke in the SHR
106. Inflammatory mediators and stroke: New opportunities for novel therapeutics
107. Response of hibernating mammals to physical, parasitic and infectious agents
108. Seasonal variation of the immune response of ground squirrels kept at 22-24°C
109. Several blood and circulatory changes in the hibernation of the 13-lined ground squirrel, Citellus tridecemlineatus
110. A comparison of bone marrow leukocytes in hibernating and nonhibernating woodchucks and ground squirrels
111. Effects of plasma from hibernating ground squirrels on monocyte-endothelial cell adhesive interactions
112. Antibody formation in hibernating ground squirrels (Citellus tridecemlineatus)
113. Effect of hibernation on the hamster spleen immune reaction in vitro
114. Brown fat: Its possible role in immunosuppression during hibernation
115. Anti-lymphoproliferative activity of brown adipose tissue of hibernating ground squirrels is mainly caused by AMP
116. Temporal impairment of microcirculatory perfusion following focal cerebral ischemia in the spontaneously hypertensive rat
117. Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model
118. One-year follow-up in acute stroke patients treated with rt-PA in clinical routine
119. Reperfusion therapy for stroke
120. Thrombolytic therapy for acute ischemic stroke
121. Prolongation of clotting time in dormant estivating mammals
122. Prolongation of blood clotting time in the dormant hamster
123. Blood coagulation studies in normothermic, hibernating and aroused Spermophius franklini
124. Relation of prothrombin to the prolongation of clotting time in aestivating ground squirrels
125. Blood clotting defect in hibernating ground squirrels (Citellus tridecemlineatus)
126. Alpha 2-Macroglobulin gene expression during hibernation in ground squirrels is independent of acute phase response
127. Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin
128. Inactivation of kallikrein in human plasma
129. Inhibition of human blood coagulation factor Xa by alpha 2-macroglobulin
130. Kinetics of the reaction of thrombin and alpha 2-macroglobulin
131. Immunosuppressive properties of electrophoretically "slow" and "fast" form alpha 2-macroglobulin. Effects on cell-mediated cytotoxicity and (allo-) antigen-induced T cell proliferation
132. Human alpha 2-macroglobulin and its biological significance
133. Alpha-2 macroglobulin is genetically associated with Alzheimer disease
134. Potentiation of NMDA receptor function by the serine protease thrombin
135. Prothrombin mRNA is expressed by cells of the nervous system
136. Immunohistochemical studies of human tissues with antibody to factor Xa
137. Thrombin may contribute to the pathophysiology of central nervous system injury
138. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities
139. Effects of alpha-thrombin on superoxide dismutase levels in human cerebral microvascular endothelial cells
140. Delayed hippocampal damage in humans following cardiorespiratory arrest
141. Progressive derangement of periinfarct viable tissue in ischemic stroke
142. The evolution of brain infarcts. A review
143. Guidelines for thrombolytic therapy for acute stroke: A supplement to the guidelines for the management of patients with acute ischemic stroke. A statement for healthcare professionals from a special writing group of the Stroke Council
144. Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke
145. A review of earlier clinical studies on neuroprotective agents and current approaches
146. Tissue plasminogen activator for acute ischemic stroke
147. Brain tissue responses to ischemia
148. The case for vascular abnormalities in Alzheimer's disease
149. Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease
150. Reactive oxygen species mediate cellular damage in Alzheimer disease
151. Critical threshold cerebral hypoperfusion causes Alzheimer's disease?