Brain tissue responses to ischemia

Journal of Clinical Investigation

Volumn 106, Issue 6, 2000, Pages 723-731

  Lee, Jin Moo ^a   Grabb, Margaret C ^a   Zipfel, Gregory J ^a   Choi, Dennis W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; 4 PHOSPHONOMETHYLPIPECOLIC ACID; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR ANTAGONIST; APTIGANEL; CEREBRYX; CITICOLINE; CLOMETHIAZOLE; DEXTROMETHORPHAN; DEXTRORPHAN; ELIPRODIL; FLUNARIZINE; FOSPHENYTOIN SODIUM; GAVESTINEL; GLUTAMIC ACID; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; LUBELUZOLE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALMEFENE; NIMODIPINE; NITRIC OXIDE SYNTHASE; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR; REMACEMIDE; REPINOTAN; SIPATRIGINE; TIRILAZAD; UNCLASSIFIED DRUG; UNINDEXED DRUG; [1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID; [[3,4 DIHYDRO 7 MORPHOLINO 2,3 DIOXO 6 (TRIFLUOROMETHYL) 1(2H) QUINOXALINYL]METHYL]PHOSPHONIC ACID;

ANIMAL MODEL; ANTIOXIDANT ACTIVITY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PROTECTION; CEREBROVASCULAR DISEASE; CLINICAL TRIAL; HUMAN; NERVE CELL NECROSIS; NEUROTRANSMISSION; NONHUMAN; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; STROKE;

EID: 0033805182     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11003     Document Type: Review

References (52)

1. Choi, D.W. 1988. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:623-634.
2. Albers, G.W., Goldberg, M.P., and Choi, D.W. 1989. N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia? Ann. Neurol. 25:398-403.
3. Buchan, A.M. 1990. Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? Cerebrovasc. Brain Metab. Rev. 2:1-26.
4. Lee, J.M., Zipfel, G.J., and Choi, D.W. 1999. The changing landscape of ischaemic brain injury mechanisms. Nature. 399:A7-A14.
5. Kerchner, G.A., Canzoniero, L.M.T., Yu, S.P., Ling, C., and Choi, D.W. 2000. Zinc current is mediated by voltage-gated calcium channels and enhanced by extracellular acidity in mouse cortical neurons. J. Physiol. In press.
6. Obrenovitch, T.P., and Richards, D.A. 1995. Extracellular neurotransmitter changes in cerebral ischaemia. Cerebrovasc. Brain Metab. Rev. 7:1-54.
7. Von Lubitz, D. 1999. Adenosine and cerebral ischemia: therapeutic future or death of a brave concept? Eur. J. Pharmacol. 15:9-25.
8. Behrens, M.M., Strasser, U., Lobner, D., and Dugan, L.L. 1999. Neurotrophin-mediated potentiation of neuronal injury. Microsc. Res. Tech. 45:276-284.
9. Frederickson, C.J. 1989. Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 31:145-238.
10. Choi, D.W., and Koh, J.Y. 1998. Zinc and brain injury. Annu. Rev. Neurosci. 21:347-375.
11. Tender, N., Johansen, F.F., Frederickson, C.J., Zimmer, J., and Diemer, N.H. 1990. Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat. Neurosci. Lett. 109:247-252.
12. Kaczmarek, L.K. 1987. The role of protein kinase C in the regulation of ion channels and neurotransmitter release. Trends Neurosci. 10:30-34.
13. Hara, H., Onodera, H., Yoshidomi, M., Matsuda, Y., and Kogure, K. 1990. Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat. J. Cereb. Blood Flow Metab. 10:646-653.
14. Nakane, H., et al. 1998. Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats. Brain Res. 782:290-296.
15. Cohen, P. 1997. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7:353-361.
16. Sugino, T., Nozaki, K., and Hashimoto, N. 2000. Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid. Neurosci. Lett. 278:101-104.
17. Alessandrini, A., Namura, S., Moskowitz, M.A., and Bonventre, J.V. 1999. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc. Natl. Acad. Sci. USA. 96:12866-12869.
18. Gonzalez-Zulueta, M., et al. 2000. Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning. Proc Natl. Acad. Sci. USA. 97:436-441.
19. Yang, D.D., et al. 1997. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389:865-870.
20. Szabo, C., and Dawson, V.L. 1998. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol. Sci. 19:287-298.
21. Andrew, P.J., and Mayer, B. 1999. Enzymatic function of nitric oxide synthases. Cardiovasc. Res. 43:521-531.
22. Samdani, A.F., Dawson, T.M., and Dawson, V.L. 1997. Nitric oxide synthase in models of focal ischemia. Stroke. 28:1283-1288.
23. Dugan, L.L., et al. 1995. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J. Neurosci. 15:6377-6388.
24. Kim, Y.H., Kim, E.Y., Gwag, B.J., Sohn, S., and Koh, J.Y. 1999. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience. 89:175-182.
25. Bonventre, J.V., et al. 1997. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phosphohpase A2. Nature. 390:622-625.
26. Umemura, A., Mabe, H., and Nagai, H. 1992. A phospholipase C inhibitor ameliorates postischemic neuronal damage in rats. Stroke. 23:1163-1166.
27. Markgraf, C.G., et al. 1998. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. Stroke. 29:152-158.
28. Wyllie, A., Kerr, J., and Currie, A. 1980. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68:251-306.
29. Schulz, J.B., Weller, M., and Moskowitz, M.A. 1999. Caspases as treatment targets in stroke and neurodegenerative diseases. Ann. Neurol. 45:421-429.
30. MacManus, J.P., and Linnik, M.D. 1997. Gene expression induced by cerebral ischemia: an apoptotic perspective. J. Cereb. Blood Flow Metab. 17:815-832.
31. Del Zoppo, G., et al. 2000. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 10:95-112.
32. Dirnagl, U., Iadecola, C., and Moskowitz, M.A. 1999. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22:391-397.
33. Williams, R.S., and Benjamin, I.J. 2000. Protective responses in the ischemic myocardium. J. Clin. Invest. In press.
34. Murry, C.E., Jennings, R.B., and Reimer, K.A. 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 74:1124-1136.
35. Kitagawa, K., et al. 1990. 'Ischemic tolerance' phenomenon found in the brain. Brain Res. 528:21-24.
36. Khaspekov, L., Shamloo, M., Victorov, I., and Wieloch, T. 1998. Sublethal in vitro glucose-oxygen deprivation protects cultured hippocampal neurons against a subsequent severe insult. Neuroreport. 9:1273-1276.
37. Grabb, M.C., and Choi, D.W., 1999. Ischemic tolerance in murine cortical cell culture: critical role for NMDA receprors. J. Neurosci. 19:1657-1662.
38. Chen, J., and Simon, R. 1997. Ischemic tolerance in the brain. Neurology. 48:306-311.
39. Wiegand, F., et al. 1999. Respiratory chain inhibition induces tolerance to focal cerebral ischemia. J. Cereb. Blood Flow Metab. 19:1229-1237.
40. Barone, F.C., et al. 1998. Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression. Stroke. 29:1937-1950.
41. Douen, A.G., et al. 2000. Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebral cortex plasma membranes. J. Neurochem. 75:812-818.
42. Zhao, Q., Pahlmark, K., Smith, M.L., and Siesjo, B.K. 1994. Delayed treatment with the spin trap alpha-phenyl-N-tert-buryl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152:349-350.
43. Goldberg, M. 2000. Washington University School of Medicine Internet Stroke Clinical Trials Database. http://www.neuro.wustl.edu/stroke.
44. Du, C., Hu, R., Csernansky, C.A., Hsu, C.Y., and Choi, D.W. 1996. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J. Cereb. Blood Flow Metab. 16:195-201.
45. Nagayama, M., Zhang, F., and Iadecola, C. 1998. Delayed treatment with ammoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats. J. Cereb. Blood Flow Metab. 18:1107-1113.
46. Kew, J.N., Trube, G., and Kemp, J.A. 1996. A novel mechanism of activity-dependent NMDA receptor antagonism describes the efrect of ifenprodil in rat cultured cortical neurones. J. Physiol. (Lond.) 497:751-772.
47. Auer, R.N. 1993. Calcium channel antagonists in cerebral ischemia: a review. Drugs Dev. 2:307-317.
48. Henkin, R.I., Patten, B.M., Re, P.K., and Bronzert, D.A. 1975. A syndrome of acute zinc loss. Cerebellar dysfunction, mental changes, anorexia, and taste and smell dysfunction. Arch. Neurol. 32:745-751.
49. Johnson, E.M. Jr., Koike, T., and Franklin, J. 1992. A "calcium set-point hypothesis" of neuronal dependence on neurotrophic factor. Exp. Neurol. 115:163-166.
50. Du, C., et al. 1996. Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected ro transient focal cerebral ischemia. Brain Res. 718:233-236.
51. Ma, J., Endres, M., and Moskowitz, M.A. 1998. Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice. Br. J. Pharmacol. 124:756-762.
52. Seregi, A., Simmer, T., Schobert, A., and Hertting, G. 1990. Characterization of cysteinyl-leukotriene formation in primary astroglial cell cultures. J. Pharm. Pharmacol. 42:191-193.