Dietary fat and colon cancer: Modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer

Cancer Research

Volumn 57, Issue 2, 1997, Pages 253-258

  Singh, Jagveer ^a   Hamid, Rachid ^a   Reddy, Bandaru S ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; PROTEIN P21; RAS PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; FAT INTAKE; GENE ACTIVATION; GENE EXPRESSION REGULATION; MALE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT;

ANIMALS; AZOXYMETHANE; BLOTTING, WESTERN; CARCINOGENS; COLON; COLONIC NEOPLASMS; CORN OIL; DIETARY FATS; FISH OILS; INTESTINAL MUCOSA; MALE; NEOPLASMS, EXPERIMENTAL; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; RATS, INBRED F344;

EID: 0031022228     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Shike, M., Winawar, S. J., Greenwald, P. H., Bloch, A., and Hill, M. J. Primary prevention of colorectal cancer: WHO collaborating center for prevention of colorectal cancer. Bull. WHO, 68: 377-385, 1990.
2. American Cancer Society. Cancer facts and figures, pp. 6-9. New York: American Cancer Society, 1996.
3. Wynder, E. L., and Gori, G. B. Contribution of the environment to cancer incidence: an epidemiologic exercise. J. Natl. Cancer Inst., 58: 825-832, 1977.
4. Lavik, P. S., and Baumann, C. A. Further studies on the tumor-promoting action of fat. Cancer Res., 3: 749-756, 1943.
5. Tannenbaum, A. Effects of varying caloric intake upon tumor incidence and tumor growth. Ann. NY Acad. Sci., 49: 5-17, 1947.
6. Stemmermann, G. N., Nomura, A. M. Y., and Heilbrun, L. K. Dietary fat and the risk of colorectal cancer. Cancer Res., 44: 4633-4637, 1984.
7. Giovannucci, E., and Willett, W. C. Dietary factors and risk of colon cancer. Ann. Med., 26: 443-452, 1994.
8. Reddy, B. S. Dietary lipids and colon cancer. In: G. A. Spiller (ed.), Handbook of Lipids in Human Nutrition, pp. 129-134. Boca Raton, FL: CRC Press Inc., 1996.
9. Newmark, H. L., Wargovich, M. J., and Bruce, W. R. Colon cancer and dietary fat, phosphate and calcium: a hypothesis. J. Natl. Cancer Inst., 72: 1323-1325, 1984.
10. Vargas, P. A., and Alberts, D. A. Primary prevention of colorectal cancer through dietary modification. Cancer (Phila.), 70 (Suppl.): 1229-1235, 1992.
11. Willett, W. C., Stampfer, M. J., Colditz, G. A., Rosner, B., and Speizer, F. E. Relation of fat, fiber, and meat intake to colon cancer risk in a prospective study among women. N. Engl. J. Med., 323: 1662-1672, 1990.
12. Reddy, B. S., and Maeura, Y. Tumor promotion by dietary fat in azoxymethane-induced colon carcinogenesis in female F344 rats: influence of amount and source of dietary fat. J. Natl. Cancer Inst., 72: 745-750, 1984.
13. Reddy, B. S., and Sugie, S. Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Res., 48: 6642-6647, 1988.
14. Torosian, M. H., Charland, S. L., and Lappin, J. A. Differential effects of omega-3 and omega-6 fatty acids on primary tumor growth and metastasis. Int. J. Oncol., 7: 667-672, 1995.
15. Hendrickse, C. W., Keighler, M. R. B., and Neoptolemos, J. P. Dietary omega-3 fats reduce proliferation and tumor yields at colorectal anastomosis in rats. Gastroenterology, 109: 431-439, 1995.
16. Reddy, B. S., Burill, C., and Rigotty, J. Effect of diets high in omega-3 and omega-6 fatty acids on initiation and postinitiation stages of colon carcinogenesis. Cancer Res., 51: 487-491, 1991.
17. Reddy, B. S. Chemoprevention of colon cancer by dietary fatty acids. Cancer Metastasis Rev., 13: 285-302, 1994.
18. Anti, M., Marra, G., Armedao, F., Bartoli, G. M., Ficarelli, R., Percesepe, A., Vitis, I., and Miggiano, G. Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology, 103: 883-891, 1992.
19. Kremer, J. M., Jubiz, M. A., Rynes, R. I., Bartholomew, L. E., Bigaouette, J., Timchalk, M., Beeler, D., and Lininger, L. Fish oil tatty acid supplementation in active rheumatoid arthritis: a double-blinded, controlled, crossover study. Ann. Intern. Med., 106: 497-503, 1987.
20. Bittiner, S. B., Tucker, W. F., Cartwright, I., and Bleehan, S. S. A double-blind, randomized, placebo-controlled trial of fish oil in psoriasis. Lancet. 1: 378-380, 1988.
21. Mascioli, E. A., Iwasz, Y., Trimbos, S. Endotoxin challenge after Menhaden oil diet: effects on survival of guinea pigs. Am. J. Clin. Nutr., 49: 277-282, 1989.
22. Roberton, A. M. Roles of endogenous substances and bacteria in colorectal cancer. Mutat. Res., 290: 71-78, 1993.
23. Reddy, B. S. Diet and colon cancer: evidence from human and animal model studies. In: B. S. Reddy and L. A. Cohen (eds.), Diet. Nutrition, and Cancer: A Critical Evaluation, pp. 47-66. Boca Raton, FL: CRC Press, 1986.
24. Rao, C. V., and Reddy, B. S. Modulating effect of amount and types of dietary fat on ornithine decarboxylase, tyrosine protein kinase and prostaglandin production during colon carcinogenesis. Carcinogenesis (Lond.), 14: 1327-1333, 1993.
25. 2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats. Cancer Res., 56: 532-537, 1996.
26. Reddy, B. S., Simi, B., Patel, N., Aliaga, C., and Rao, C. V. Effect of amount and types of dietary fat on intestinal bacterial 7-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during different stages of colon tumor promotion. Cancer Res., 56: 2314-2320, 1996.
27. Bishop, J. M. The molecular genetics of cancer. Science (Washington DC), 235: 305-311, 1989.
28. Egan, S. E., and Weinberg, R. A. The pathway to signal achievement. Nature (Lond.), 365: 781-783, 1993.
29. Barbacid, M. Ras oncogenes: their role in neoplasia. Eur. J. Clin. Invest., 20: 225-235, 1990.
30. Spandidos, D. A. (ed.) Ras oncogenes, pp. 1-323. New York, London: Plenum Press, 1989.
31. Der, C. J., and Cox, A. D. Isoprenoid modification and plasma membrane associations: critical factors for ras oncogenicity. Cancer Cells (Cold Spring Harbor), 3: 331-340, 1991.
32. Willumsen, B. M., Papageorge, A. G., Kung, H., Bakesi, E., Robins, T., Johnson, M., Vass, W. C., and Lowy, D. R. Mutational analysis of ras catalytic domain. Mol. Cell. Biol., 6: 2646-2654, 1986.
33. Schafer, W. R., Kim, R., Sterne, R., Thorner, J., Kim, S-H., and Rine, J. Genetic and pharmacologic suppression of oncogenic mutations in RAS genes of yeast and humans. Science (Washington DC), 245: 379-385, 1989.
34. Kato, K., Cox, A. D., Hisaka, M. M., Graham, S. M., Buss, J. E., and Der, C. J. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc. Natl. Acad. Sci. USA, 89: 6403-6407, 1992.
35. Willumsen, B. M., Norris, K., Papageorge, A. G., Hubbert, N. C., and Lowy, D. R. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxyl terminus. EMBO J., 3: 2581-2585, 1984.
36. Willumsen, B. M., Christensen, A., Hubbert, N. C., Papageorge, A. G., and Lowy, D. R. The p21 ras c-terminus is required for transformation and membrane association. Nature (Lond.), 310: 583-586, 1984.
37. Goldstein, J. L., and Brown, M. S. Regulation of the mevalonate pathway. Nature (Lond.), 343: 425-430, 1990.
38. Cox, A. D., and Der, C. J. The ras/cholesterol connection: implications for ras oncogenicity. Crit. Rev. Oncog., 3: 365, 1992.
39. Stacey, D. W., Feig, L. A., and Gibbs, J. B. Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras. Mol. Cell. Biol., 11: 4053-4064, 1991.
40. Goldfarb, S., and Pitot, H. C. The regulation of β hydroxy-β-methylglutaryl coenzyme A reductase in Morris hepatomas 5123C, 7800, and 9618A. Cancer Res., 31: 1879-1882, 1971.
41. Singh, J., Rao, C. V., Kulkarni, N., Simi, B., and Reddy, B. S. Molecular markers as intermediate end-points in chemoprevention of colon cancer: modulation of ras activation by sulindac and phenylhexylisothiocyanate during colon carcinogenesis. Int. J. Oncol., 5: 1009-1018, 1994.
42. 4. Nature (Lond.), 227: 680-685, 1970.
43. Towbin, H., Stachelin, T., and Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedures and some applications. Proc. Natl. Acad. Sci. USA. 76: 4350-4354, 1979.
44. Singh, J., Kelloff, G., and Reddy, B. S. Intermediate biomarkers of colon cancer: modulation of expression of ras oncogene by chemopreventive agents during azoxymethane-induced colon carcinogenesis. Carcinogenesis (Lond.), 14: 699-704, 1993.
45. Sebti, S. M. Tkalcevic, G. T., and Jani, P. Lovastatin, a cholesterol inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice. Cancer Commun., 3: 141-147, 1991.
46. Ruch, R. J., Madhukar, B. V., Trosko, J. E., and Klaunig, J. E. Reversal of ras-induced inhibition of gap junctional intracellular communication, transformation, and tumorigenesis by lovastatin. Mol. Carcinog., 7: 50-59, 1993.
47. Goodman, L. E., Judd, S. R., Farnsworth, C. C., Powers, S., Gelb, M. H., Glomset, J. A., and Tamanoi, F. Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins. Proc. Natl. Acad. Sci. USA, 87: 9665-9669, 1990.
48. Rudney, H., and Sexton, R. C. Regulation of cholesterol biosynthesis. Annu. Rev. Nutr., 6: 245, 1986.
49. McNamara, D. J. Effects of fat-modified diets on cholesterol and lipoprotein metabolism. Annu. Rev. Nutr., 7: 273, 1987.
50. Nestel, P. J., Wong, S., and Topping, D. L. Dietary long chain polyenoic fatty acids: (I) Suppression of triglycerides formation in rat liver; (II) attenuation in man of the effects of dietary cholesterol on lipoprotein cholesterol. In: A. E. Simopoulos, R. R. Kifer, and R. E. Martin (eds.), Health Effects of Polyunsaturated Fatty Acids in Seafoods, p. 211. New York: Academic Press, 1986.
51. Gibbs, J. B., Oliff, A., and Kohl, N. E. Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell, 77: 175-178, 1994.
52. Kohl, N. E., Wilson, F. R., Mosser, S. D., Guliani, E., Desolms, J. S., Conner, M. W., Anthony, N. J., Holtz, W. J., Gomez, R. P., Lee, T-J., Smith, R. L., Graham, S. L., Hartman, G. D., Gibbs, J. B., and Oliff, A. Farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc. Natl. Acad. Sci. USA, 91: 9141-9145, 1994.