mRNA turnover

Current Opinion in Cell Biology

Volumn 13, Issue 3, 2001, Pages 320-325

  Mitchell, P ^a   Tollervey, D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MESSENGER RNA; MESSENGER RNA PRECURSOR; NUCLEAR PROTEIN; RIBONUCLEOPROTEIN;

PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN STRUCTURE; REVIEW; RNA DEGRADATION; RNA SPLICING; RNA TRANSLATION;

EID: 0035371050     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00214-3     Document Type: Review

References (55)

1. The hrp23 protein in the balbiani ring pre-mRNP particles is released just before or at the binding of the particles to the nuclear pore complex
2. The double lives of shuttling mRNA binding proteins
3. Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking
4. Lipoxygenase mRNA silencing in erythroid differentiation: The 3′UTR regulatory complex controls 60S ribosomal subunit joining
5. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation
6. 2 is mediated by enhanced cyclin D1 mRNA turnover
7. Protein ligands to HuR modulate its interaction with target mRNAs in vivo
8. A splicing-dependent regulatory mechanism that detects translation signals
9. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
10. Pre-mRNA splicing alters mRNP composition evidence for stable association of proteins at exon-exon junctions
11. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
12. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
13. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
14. Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF
15. At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: A possible link between nuclear splicing and cytoplasmic translation
16. Intron function in the nonsense-mediated decay of beta-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm
17. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
18. Novel upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes
19. Identification and characterization of human orthologues to Saccharomyces cerevisiae upf2 protein and upf3 protein (Caenorhabditis elegans SMG-4)
20. Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p
21. Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability
22. Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position
23. Identification of a regulated turnover pathway for nuclear pre-mRNAs
24. The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation
25. The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay
26. Control of cleavage site selection during mRNA 3′ end formation by a yeast hnRNP
27. Aberrant mRNAs with extended 3′ UTRs are substrates for rapid degradation by mRNA surveillance
28. Splicing and 3′ end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs
29. The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability
30. Identifying the right stop: Determining how the surveillance complex recognizes and degrades an aberrant mRNA
31. The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames
32. A mechanism for translationally coupled mRNA turnover: Interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex
33. The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation
34. Uncoupling DNA translocation and helicase activity in PcrA: Direct evidence for an active mechanism
35. Mechanisms of mRNA surveillance in eukaryotes
36. mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E
37. Stabilization of eukaryotic initiation factor 4E binding to the mRNA 5′-Cap by domains of eIF4G
38. The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex
39. Two Related Proteins, Edc1p and Edc2p, Stimulate mRNA Decapping in Saccharomyces cerevisiae
40. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif
41. Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme
42. Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae
43. A Sm-like protein complex that participates in mRNA degradation
44. Yeast Smlike proteins function in mRNA decapping and decay
45. Deletion of the PAT1 gene affects translation initiation and suppresses a PAB1 gene deletion in yeast
46. Characterization of Sm-like proteins in yeast and their association with U6 snRNA
47. A novel mRNA decapping activity in Hela cytoplasmic extracts is regulated by AU-rich elements
48. AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation
49. Cap-dependent deadenylation of mRNA
50. Interaction between a poly(A) specific ribonuclease and the 5′ cap influences mRNA degradation rates in vitro
51. A 54-kDa fragment of the poly(A)-specific ribonuclease is an oligomeric, processive, and cap-interacting poly(A)-specific 3′ exonuclease
52. The transcription factor associated proteins, Ccr4p and Caf1p, are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae
53. The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast
54. Post-transcriptional regulation through the HO 3′-UTR by Mpt5, a yeast homolog of Pumilio and FBF
55. NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans