NMR methodology for the study of nucleic acids

Current Opinion in Structural Biology

Volumn 11, Issue 3, 2001, Pages 275-281

  Zidek L ^a   Stefl R ^a   Sklenar V ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN; NUCLEIC ACID;

ACCURACY; ANISOTROPY; CHEMICAL STRUCTURE; EXPERIMENT; HYDROGEN BOND; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS; TECHNIQUE;

EID: 0035366106     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00218-9     Document Type: Review

References (62)

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2. Spin-locked multiple quantum coherence for signal enhancement in heteronuclear multidimensional NMR experiments
3. 13C-labeled RNA
4. Optimization of triple-resonance HCN experiments for application to larger RNA oligonucleotides
5. 15N labeled oligonucleotides
6. 15N labeled RNA oligonucleotides
7. Sensitivity improvement in proton-detected 2-dimensional heteronuclear correlation NMR spectroscopy
8. Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity
9. 15N labeled RNA oligonucleotides
10. 13C-labeled nucleic acids and their protein complexes
11. 2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution
12. 13C NMR experiments of RNA
13. Transverse relaxation optimized triple-resonance NMR experiments for nucleic acids
14. 1H]-TROSY in a triple resonance experiment for ribose-base and intrabase correlations in nucleic acids
15. 1H chemical shielding tensors in the Watson-Crick base pairs
16. 1H shielding tensors in nucleic acid base pairs
17. NMR scalar couplings across Watson-Crick base pair hydrogen bonds in DNA observed by transverse relaxation optimized spectroscopy
18. NN couplings
19. Internucleotide scalar couplings across hydrogen bonds in Watson-Crick and Hoogsteen base pairs of a DNA triplex
20. Direct identification of NH...N hydrogen bonds in non-canonical base pairs of RNA by NMR spectroscopy
21. 15N nuclei with widely separated chemical shifts
22. HN coupling constants across Watson-Crick base pairs in the Antennapedia homeodomain-DNA complex using TROSY
23. Detection of N-H...N hydrogen bonding in RNA via scalar couplings in the absence of observable imino proton resonances
24. Observation of internucleotide NH...N hydrogen bonds in the absence of directly detectable protons
25. Direct evidence for Watson-Crick base pairs in a dynamic region of RNA structure
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27. 15N 1D NMR
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32. 1H two-bond couplings
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34. A comprehensive approach for accurate measurement of proton-proton coupling constants in the sugar ring of DNA
35. 15N-spin relaxation: Correlations with structure and stability
36. 13C relaxation and dynamics of the purine bases in the iron responsive element RNA hairpin
37. 13C spin relaxation measurements in RNA: Sensitivity and resolution improvement using spin-state selective correlation experiments
38. HH coupling constants
39. Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium
40. New techniques in structural NMR - Anisotropic interactions
41. Bicelle-based liquid crystals for NMR-measurement of dipolar couplings at acidic and basic pH values
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43. Pf1 filamentous phage as an alignment tool for generating local and global structural information in nucleic acids
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45. Purple membrane induced alignment of biological macromolecules in the magnetic field
46. Characterization of surfactant liquid crystal phases suitable for molecular alignment and measurement of dipolar couplings
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48. Alignment of biopolymers in strained gels: A new way to create detectable dipole-dipole couplings in high-resolution biomolecular NMR
49. Solution NMR of proteins within polyacrylamide gels: Diffusional properties and residual alignment by mechanical stress or embedding of oriented purple membranes
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51. Refinement of the structure of protein-RNA complexes by residual dipolar coupling analysis
52. The NMR structure of a DNA dodecamer in aqueous dilute liquid crystalline phase
53. A new approach for applying residual dipolar couplings as restraints in structure elucidation
54. Determining DNA global structure and DNA bending by application of NMR residual dipolar couplings
55. Global structure of RNA determined with residual dipolar couplings
56. A method for direct determination of helical parameters in nucleic acids using residual dipolar couplings
57. Field- and phage-induced dipolar couplings in a homodimeric DNA quadruplex: Relative orientation of G·(C-A) triad and G-tetrad motifs and direct determination of C2 symmetry axis orientation
58. Determination of the populations and structures of multiple conformers in an ensemble from NMR data: Multiple-copy refinement of nucleic acid structures using floating weights
59. A second generation force field for the simulation of proteins, nucleic acids, and organic molecules
60. All-atom empirical force field for nucleic acids: I. Parameter optimization based on small molecule and condensed phase macromolecular target data
61. Molecular dynamics simulation of nucleic acids
62. Molecular dynamics simulations of nucleic acids with a generalized Born solvation model