-
1
-
-
0034089010
-
Viral vectors for gene delivery and therapy in the endocrine system
-
Stone, D. et al. (2000) Viral vectors for gene delivery and therapy in the endocrine system. J. Endocrinol. 164, 103-118
-
(2000)
J. Endocrinol.
, vol.164
, pp. 103-118
-
-
Stone, D.1
-
2
-
-
0033544491
-
Human gene marker/therapy clinical protocols (complete updated listings)
-
Human gene marker/therapy clinical protocols (complete updated listings) (1999) Hum. Gene Ther. 10, 3067-3123
-
(1999)
Hum. Gene Ther.
, vol.10
, pp. 3067-3123
-
-
-
3
-
-
0034724857
-
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
-
Cavazzana, C. et al. (2000) Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288, 669-672
-
(2000)
Science
, vol.288
, pp. 669-672
-
-
Cavazzana, C.1
-
4
-
-
0029993858
-
Efficient transfer, integration, and sustained long term expression of the transgene in adult rat brains injected with a lentiviral vector
-
Naldini, L. et al. (1997) Efficient transfer, integration, and sustained long term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl. Acad. Sci. U. S. A. 93, 11382-11388
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 11382-11388
-
-
Naldini, L.1
-
5
-
-
0032191380
-
Lentiviruses as gene transfer agents for delivery to non-dividing cells
-
Naldini, L. et al. (1998) Lentiviruses as gene transfer agents for delivery to non-dividing cells. Curr. Opin. Biotechnol. 9, 457-463
-
(1998)
Curr. Opin. Biotechnol.
, vol.9
, pp. 457-463
-
-
Naldini, L.1
-
6
-
-
0030775646
-
Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector
-
Feng, M. et al. (1997) Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector. Nat. Biotechnol. 15, 866-870
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 866-870
-
-
Feng, M.1
-
7
-
-
84992281634
-
Functional characterization of adenoviral/retroviral producer cell lines
-
Duisit, G. et al. (1999) Functional characterization of adenoviral/retroviral producer cell lines. Hum. Gene Ther. 20, 189-200
-
(1999)
Hum. Gene Ther.
, vol.20
, pp. 189-200
-
-
Duisit, G.1
-
8
-
-
0033544015
-
Gene transfer to the nigrostriatal system by hybrid herpes simplex virus amplicon vectors
-
Constantini, L.C. et al. (1999) Gene transfer to the nigrostriatal system by hybrid herpes simplex virus amplicon vectors. Hum. Gene Ther. 10, 2481-2494
-
(1999)
Hum. Gene Ther.
, vol.10
, pp. 2481-2494
-
-
Constantini, L.C.1
-
9
-
-
0030812867
-
HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells
-
Johnston, K.M. et al. (1997) HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells. Hum. Gene Ther. 8, 359-370
-
(1997)
Hum. Gene Ther.
, vol.8
, pp. 359-370
-
-
Johnston, K.M.1
-
10
-
-
0029944988
-
Transient immune blockade prevents formation of neutralizing antibody adenovirus and allows repeated gene transfer to mouse liver
-
Yang, Y. et al. (1996) Transient immune blockade prevents formation of neutralizing antibody adenovirus and allows repeated gene transfer to mouse liver. Gene Ther. 3, 412-420
-
(1996)
Gene Ther.
, vol.3
, pp. 412-420
-
-
Yang, Y.1
-
11
-
-
0029876694
-
Immunological instability of persistent adenovirus vectors in the brain. Peripheral exposure to vector leads to renewed inflammation, reduced gene expression and demyelination
-
Byrnes, A.P. et al. (1996) Immunological instability of persistent adenovirus vectors in the brain. Peripheral exposure to vector leads to renewed inflammation, reduced gene expression and demyelination. J. Neurosci. 16, 3045-3055
-
(1996)
J. Neurosci.
, vol.16
, pp. 3045-3055
-
-
Byrnes, A.P.1
-
12
-
-
17344366044
-
Impact of preexisting and induced humoral and cellular immune response to gene therapy phase 1 clinical trial for localized mesothelioma
-
Molnar-Kimber, K.L. et al. (1998) Impact of preexisting and induced humoral and cellular immune response to gene therapy phase 1 clinical trial for localized mesothelioma. Hum. Gene Ther. 9, 2121-2133
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 2121-2133
-
-
Molnar-Kimber, K.L.1
-
13
-
-
0033977047
-
Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscle
-
Chirmule, N. et al. (2000) Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscle. J. Virol. 74, 2420-2425
-
(2000)
J. Virol.
, vol.74
, pp. 2420-2425
-
-
Chirmule, N.1
-
14
-
-
0034022384
-
Effective repeat administration with adenovirus vectors to the muscle
-
Chen, P. et al. (2000) Effective repeat administration with adenovirus vectors to the muscle. Gene Ther. 7, 587-595
-
(2000)
Gene Ther.
, vol.7
, pp. 587-595
-
-
Chen, P.1
-
15
-
-
0025270923
-
Transcriptional repression of herpes simplex virus immediate-early genes and of octamer containing cellular promoters in neuronal cells is mediated by the octamer DNA element
-
Kemp, L.M. et al. (1990) Transcriptional repression of herpes simplex virus immediate-early genes and of octamer containing cellular promoters in neuronal cells is mediated by the octamer DNA element. Neuron 4, 215-222
-
(1990)
Neuron
, vol.4
, pp. 215-222
-
-
Kemp, L.M.1
-
16
-
-
0027408530
-
Transfer of a foreign gene into the brain using adenovirus vectors
-
Akli, S. et al. (1993) Transfer of a foreign gene into the brain using adenovirus vectors. Nat. Genet. 3, 224-228
-
(1993)
Nat. Genet.
, vol.3
, pp. 224-228
-
-
Akli, S.1
-
17
-
-
0028363927
-
Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro
-
Lowenstein, P.R. et al. (1994) Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro. Neuroscience 60, 1059-1077
-
(1994)
Neuroscience
, vol.60
, pp. 1059-1077
-
-
Lowenstein, P.R.1
-
18
-
-
0030973598
-
Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: Long term expression, cell cycle dependency, and effects on hormone secretion
-
Castro, M.G. et al. (1997) Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion. Endocrinology 138, 2184-2194
-
(1997)
Endocrinology
, vol.138
, pp. 2184-2194
-
-
Castro, M.G.1
-
19
-
-
0031465261
-
Long-term gene therapy in the CNS: Reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin
-
Geddes, B.J. et al. (1997) Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Nat. Med. 3, 1402-1404
-
(1997)
Nat. Med.
, vol.3
, pp. 1402-1404
-
-
Geddes, B.J.1
-
20
-
-
0032580270
-
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells
-
Goya, R. et al. (1998) Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells. Mol. Cell. Endocrinol. 138, 199-207
-
(1998)
Mol. Cell. Endocrinol.
, vol.138
, pp. 199-207
-
-
Goya, R.1
-
21
-
-
0032741719
-
Chronic brain inflammation and persistent HSV1-TK expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials
-
Dewey R.A. et al. (1999) Chronic brain inflammation and persistent HSV1-TK expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials. Nat. Med. 5, 1256-1263
-
(1999)
Nat. Med.
, vol.5
, pp. 1256-1263
-
-
Dewey, R.A.1
-
22
-
-
0033585514
-
Adeno-associated virus-mediated gene transfer to the brain: Duration and modulation of expression
-
Lo, W.D. et al. (1999) Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression. Hum. Gene Ther. 10, 201-213
-
(1999)
Hum. Gene Ther.
, vol.10
, pp. 201-213
-
-
Lo, W.D.1
-
23
-
-
0024322243
-
Organisation of adeno-associated virus DNA in latency infected Detroit 6 cells
-
Kotin, RM. and Berns, K.I. (1989) Organisation of adeno-associated virus DNA in latency infected Detroit 6 cells. Virology 170, 460-467
-
(1989)
Virology
, vol.170
, pp. 460-467
-
-
Kotin, R.M.1
Berns, K.I.2
-
24
-
-
0031471130
-
Long-term correction of obesity and diabetes in genetically obese mice by a single injection of recombinant adeno-associated virus encoding mouse leptin
-
Murphy, J.E. et al. (1997) Long-term correction of obesity and diabetes in genetically obese mice by a single injection of recombinant adeno-associated virus encoding mouse leptin. Proc. Natl. Acad Sci. U. S. A. 94, 13921-13926
-
(1997)
Proc. Natl. Acad Sci. U. S. A.
, vol.94
, pp. 13921-13926
-
-
Murphy, J.E.1
-
25
-
-
0035117983
-
Long-term transgene expression within the anterior pituitary gland in situ: Impact on circulating hormone levels, cellular and antibody-mediated immune responses
-
Southgate, T.D. et al. (2001) Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses. Endocrinology 142, 464-476
-
(2001)
Endocrinology
, vol.142
, pp. 464-476
-
-
Southgate, T.D.1
-
26
-
-
0034691208
-
Peripheral infection with adenovirus causes unexpected long term brain inflammation in animals injected intracranially with first generation, but not with high-capacity adenovirus vectors: Towards realistic long-term neurological gene therapy for chronic diseases
-
Thomas, C.E. et al. (2000) Peripheral infection with adenovirus causes unexpected long term brain inflammation in animals injected intracranially with first generation, but not with high-capacity adenovirus vectors: towards realistic long-term neurological gene therapy for chronic diseases. Proc. Natl. Acad. Sci. U. S. A. 97, 7482-7487
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 7482-7487
-
-
Thomas, C.E.1
-
27
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad Sci. U. S. A. 89, 5547-5551
-
(1992)
Proc. Natl. Acad Sci. U. S. A.
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
28
-
-
9544226448
-
A humanized system for pharmacologic control of gene expression
-
Rivera, V.M. et al. (1996) A humanized system for pharmacologic control of gene expression. Nat. Med. 2, 21028-21032
-
(1996)
Nat. Med.
, vol.2
, pp. 21028-21032
-
-
Rivera, V.M.1
-
29
-
-
0031838298
-
Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system
-
Harding, T.C. et al. (1998) Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system. Nat. Biotechnol. 16, 553-555
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 553-555
-
-
Harding, T.C.1
-
30
-
-
0032893035
-
A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors
-
Corti, O. et al. (1999) A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors. Nat. Biotechnol. 17, 349-354
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 349-354
-
-
Corti, O.1
-
31
-
-
0034567011
-
Cell type specific and regulatable transgenesis in the adult brain: Adenovirus-encoded combined transcriptional targeting and inducible transgene expression
-
Smith-Arica, J. et al. (2000) Cell type specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression. Mol. Ther. 2, 579-587
-
(2000)
Mol. Ther.
, vol.2
, pp. 579-587
-
-
Smith-Arica, J.1
-
32
-
-
17744368892
-
Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride induced hyperplastic anterior pituitaries
-
Southgate, T.D. et al. (2000) Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride induced hyperplastic anterior pituitaries. Endocrinology 141, 3493-3505
-
(2000)
Endocrinology
, vol.141
, pp. 3493-3505
-
-
Southgate, T.D.1
-
33
-
-
0034986065
-
Acute direct adenoviral vector cytotoxicity, and chronic, but not acute inflammatory responses correlate with decreased vector mediated transgene expression in the brain
-
Thomas, C. et al. (2001) Acute direct adenoviral vector cytotoxicity, and chronic, but not acute inflammatory responses correlate with decreased vector mediated transgene expression in the brain. Mol. Ther. 3. 36-46
-
(2001)
Mol. Ther.
, vol.3
, pp. 36-46
-
-
Thomas, C.1
-
34
-
-
17744390776
-
Adenovirus-mediated HSV-1 thymidine kinase gene therapy suppressed oestrogen induced pituitary prolactinomas
-
Windeatt, S. et al. (2000) Adenovirus-mediated HSV-1 thymidine kinase gene therapy suppressed oestrogen induced pituitary prolactinomas. J. Clin. Endocrinol. Metab. 85, 1296-1306
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 1296-1306
-
-
Windeatt, S.1
-
35
-
-
0031203822
-
Why are we doing so much cancer gene therapy? Disentangling the scientific basis from the origins of gene therapy
-
Lowenstein, P.R. (1997) Why are we doing so much cancer gene therapy? Disentangling the scientific basis from the origins of gene therapy. Gene Ther. 4, 755-756
-
(1997)
Gene Ther.
, vol.4
, pp. 755-756
-
-
Lowenstein, P.R.1
-
36
-
-
0024466634
-
Resistance to bromocriptine in prolactinomas
-
Pellegrini, I. et al. (1989) Resistance to bromocriptine in prolactinomas. J. Clin. Endocrinol. Metab. 69, 500-509
-
(1989)
J. Clin. Endocrinol. Metab.
, vol.69
, pp. 500-509
-
-
Pellegrini, I.1
-
37
-
-
0028170513
-
Decreased expression of the two D2 dopamine receptor isoforms in bromocriptine-resistant prolactinomas
-
Caccavilli, L. et al. (1994) Decreased expression of the two D2 dopamine receptor isoforms in bromocriptine-resistant prolactinomas. Neuroendocrinology 60, 314-322
-
(1994)
Neuroendocrinology
, vol.60
, pp. 314-322
-
-
Caccavilli, L.1
-
38
-
-
0031017930
-
Prolactinomas resistant to standard dopamine agonists respond to chronic cabergoline therapy
-
Colao, A. et al. (1997) Prolactinomas resistant to standard dopamine agonists respond to chronic cabergoline therapy. J. Clin. Endocrinol. Metab. 82, 876-883
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 876-883
-
-
Colao, A.1
-
39
-
-
0031203016
-
Extensive surgical experience. Surgical management of pituitary tumors
-
Wilson, C.B. (1997) Extensive surgical experience. Surgical management of pituitary tumors. J. Clin. Endocrinol. Metab. 82, 2381-2385
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 2381-2385
-
-
Wilson, C.B.1
-
40
-
-
0032951833
-
Transsphenoidal microsurgical therapy of prolactinomas: Initial outcomes and long term results
-
Tyrrell, J.B. et al. (1999) Transsphenoidal microsurgical therapy of prolactinomas: initial outcomes and long term results. Neurosurgery 44, 254-263
-
(1999)
Neurosurgery
, vol.44
, pp. 254-263
-
-
Tyrrell, J.B.1
-
41
-
-
0031439067
-
Radiation optic neuropathy after stereotactic radiosurgery
-
Girkin, C.A. et al. (1997) Radiation optic neuropathy after stereotactic radiosurgery Ophthalmology 104, 1634-1643
-
(1997)
Ophthalmology
, vol.104
, pp. 1634-1643
-
-
Girkin, C.A.1
-
42
-
-
0027169709
-
Glioma arising after radiation therapy for pituitary adenoma
-
Tsang, R.W. et al. (1993) Glioma arising after radiation therapy for pituitary adenoma. Cancer 72, 2227-2233
-
(1993)
Cancer
, vol.72
, pp. 2227-2233
-
-
Tsang, R.W.1
-
43
-
-
0026056559
-
Radiation oncogenesis in relation to the treatment of pituitary tumours
-
Jones, A. (1991) Radiation oncogenesis in relation to the treatment of pituitary tumours. Clin. Endocrinol. 35, 379-397
-
(1991)
Clin. Endocrinol.
, vol.35
, pp. 379-397
-
-
Jones, A.1
-
44
-
-
0013413890
-
Experimental and clinical gene therapies for brain tumours
-
Chiocca, E.A. and Breakefield, X.O., eds, Humana Press
-
Chiocca, E.A. (1998) Experimental and clinical gene therapies for brain tumours. In Gene Therapy for Neurological Disorders and Brain Tumours (Chiocca, E.A. and Breakefield, X.O., eds), pp. 191-203, Humana Press
-
(1998)
Gene Therapy for Neurological Disorders and Brain Tumours
, pp. 191-203
-
-
Chiocca, E.A.1
-
45
-
-
0033400627
-
The basic science of brain-tumour gene therapy
-
Lowenstein, P.R. et al. (1999) The basic science of brain-tumour gene therapy. Biochem. Soc. Trans. 27, 873-881
-
(1999)
Biochem. Soc. Trans.
, vol.27
, pp. 873-881
-
-
Lowenstein, P.R.1
-
46
-
-
0031581176
-
Afamily of bicistronic vectors to enhance both local and systemic antitumour effects of HSVtk or cytokine expression in a murine melanoma model
-
Castleden, S.A. et al. (1997) Afamily of bicistronic vectors to enhance both local and systemic antitumour effects of HSVtk or cytokine expression in a murine melanoma model. Hum. Gene Ther. 8, 2087-2102
-
(1997)
Hum. Gene Ther.
, vol.8
, pp. 2087-2102
-
-
Castleden, S.A.1
-
47
-
-
0032848688
-
Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated responses and causes apoptotic death or tumour cells in vivo
-
Kuriyama, S. et al. (1999) Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated responses and causes apoptotic death or tumour cells in vivo. Int. J. Cancer 83, 374-380
-
(1999)
Int. J. Cancer
, vol.83
, pp. 374-380
-
-
Kuriyama, S.1
-
48
-
-
0032979226
-
Targeted expression of toxic genes directed by pituitary hormone promoters: A potential strategy for adenovirus-mediated gene therapy of pituitary tumors
-
Lee, E.J. et al. (1999) Targeted expression of toxic genes directed by pituitary hormone promoters: a potential strategy for adenovirus-mediated gene therapy of pituitary tumors. J. Clin. Endocrinol. Metab. 84, 786-794
-
(1999)
J. Clin. Endocrinol. Metab.
, vol.84
, pp. 786-794
-
-
Lee, E.J.1
-
49
-
-
0034515396
-
Stereotactic injection of adenoviral vectors that target gene expression to specific pituitary cell types: Implications for gene therapy
-
Lee, E.J. et al. (2000) Stereotactic injection of adenoviral vectors that target gene expression to specific pituitary cell types: implications for gene therapy. Neurosurgery 46, 1461-1468
-
(2000)
Neurosurgery
, vol.46
, pp. 1461-1468
-
-
Lee, E.J.1
-
50
-
-
0033512621
-
Mitosis and apoptosis in the pituitary gland: Tumour formation or hyperplasia?
-
Holly, J.M.P., ed., Harcourt Brace
-
Levy, A. (1999) Mitosis and apoptosis in the pituitary gland: tumour formation or hyperplasia? In Bailliere's Best Practise and Research in Endocrinology and Metabolism (Vol. 13) (Holly, J.M.P., ed.), pp. 353-365, Harcourt Brace
-
(1999)
Bailliere's Best Practise and Research in Endocrinology and Metabolism
, vol.13
, pp. 353-365
-
-
Levy, A.1
-
51
-
-
0033831080
-
A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
-
Khuri, F.R. et al. (2000) A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat. Med. 6, 879-885
-
(2000)
Nat. Med.
, vol.6
, pp. 879-885
-
-
Khuri, F.R.1
-
52
-
-
0027970092
-
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly, M.S. et al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315-328
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.S.1
-
53
-
-
0029944122
-
Angiostatin induces and sustains dormancy of human primary tumours in mice
-
O'Reilly, M.S. et al. (1996) Angiostatin induces and sustains dormancy of human primary tumours in mice. Nat. Med. 2, 689-692
-
(1996)
Nat. Med.
, vol.2
, pp. 689-692
-
-
O'Reilly, M.S.1
-
54
-
-
0033954001
-
Targeting adenovirus
-
Wickham, T.J. (2000) Targeting adenovirus. Gene Ther. 7, 110-114
-
(2000)
Gene Ther.
, vol.7
, pp. 110-114
-
-
Wickham, T.J.1
-
55
-
-
0028807727
-
T lymphocyte-directed gene therapy for ADA-SCID: Initial results after 4 years
-
Blaese, R.M. et al. (2000) T lymphocyte-directed gene therapy for ADA-SCID: initial results after 4 years. Science 270, 475-480
-
(2000)
Science
, vol.270
, pp. 475-480
-
-
Blaese, R.M.1
-
56
-
-
0015492624
-
Gene therapy for human genetic disease?
-
Friedmann, T. and Roblin, R. (1972) Gene therapy for human genetic disease? Science 175, 949-955
-
(1972)
Science
, vol.175
, pp. 949-955
-
-
Friedmann, T.1
Roblin, R.2
|