T lymphocyte-directed gene therapy for ADA-SCID: Initial trial results after 4 years

Science

Volumn 270, Issue 5235, 1995, Pages 475-480

  Blaese, R Michael ^a,b,h   Culver, Kenneth W ^b   Miller, A Dusty ^c   Carter, Charles S ^d   Fleisher, Thomas ^d   Clerici, Mario ^b,i   Shearer, Gene ^b   Chang, Lauren ^e   Chiang, Yawen ^f   Tolstoshev, Paul ^f   Greenblatt, Jay J ^b   Rosenberg, Steven A ^b   Klein, Harvey ^d   Berger, Melvin ^g   Mullen, Craig A ^a,b,j   Ramsey, W Jay ^a,b   Muul, Linda ^a   Morgan, Richard A ^a,e   Anderson, W French ^e,k  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c FRED HUTCHINSON CANCER RESEARCH CENTER   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

^g CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h M D Anderson Cancer Center ^*

ⁱ UNIVERSITY OF MILAN   (Italy)

^j UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^k UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE;

ARTICLE; CASE REPORT; CELLULAR IMMUNITY; CLINICAL TRIAL; CLONING VECTOR; COMBINED IMMUNODEFICIENCY; ENZYME DEFICIENCY; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMORAL IMMUNITY; PRIORITY JOURNAL; RETROVIRUS; T LYMPHOCYTE;

ADENOSINE DEAMINASE; ANTIBODY FORMATION; BASE SEQUENCE; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMAN; IMMUNITY, CELLULAR; LYMPHOCYTE COUNT; LYMPHOCYTE TRANSFUSION; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; SEVERE COMBINED IMMUNODEFICIENCY; T-LYMPHOCYTES;

EID: 0028807727     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.270.5235.475     Document Type: Article

References (76)