Targeted expression of toxic genes directed by pituitary hormone promoters: A potential strategy for adenovirus-mediated gene therapy of pituitary tumors

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 2, 1999, Pages 786-794

  Lee, Eun Jig ^a   Anderson, Leonard M ^a   Thimmapaya, Bayar ^a   Jameson, J Larry ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOPHYSIS HORMONE; VIRUS VECTOR;

ADENOVIRUS; ALPHA CHAIN; ANIMAL CELL; ARTICLE; CYTOTOXICITY; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; HORMONE RELEASE; HYPOPHYSIS TUMOR; MARKER GENE; MOUSE; NONHUMAN; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROMOTER REGION; SELLA TURCICA; TUMOR VOLUME;

ADENOMA; ADENOVIRIDAE; ANIMALS; ANTIVIRAL AGENTS; BETA-GALACTOSIDASE; GANCICLOVIR; GENE TARGETING; GENE THERAPY; GENETIC MARKERS; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HUMAN GROWTH HORMONE; HUMANS; MICE; MICE, NUDE; PITUITARY HORMONES; PITUITARY NEOPLASMS; PROMOTER REGIONS (GENETICS); SIMPLEXVIRUS; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; HERPES; MUS MUSCULUS; SIMPLEXVIRUS; TURCICA;

EID: 0032979226     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.2.786     Document Type: Article

References (48)

1. 1. Daniels GH, Martin JB. 1995 Neuroendocrine regulation and diseases of the anterior pituitary and hypothalamus. In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL, ed. Harrison's principles of internal medicine, 13th ed. New York: McGraw-Hill; 1891-1918.
2. 2. Shimon I, Melmed S. 1998 Management of pituitary tumors. Ann Intern Med. 129:472-483.
3. 3. Lee EJ, Jameson JL. 1997 Gonadotropin (FSH and LH) pituitary tumors. In: Wierman ME, ed. Disease of the pituitary: diagnosis and treatment. Totowa: Humana Press; 247-272.
4. 4. Melmed S. 1997 General aspects of the management of pituitary tumors by surgery or radiation therapy. In: DeGroot LJ, ed. Endocrinology, 3rd ed. Philadelphia: Saunders; 497-503.
5. 5. Schlechte JA. 1997 Differential diagnosis and management of hyperprolactinemia. In: Wierman ME, ed. Disease of the pituitary: diagnosis and treatment. Totowa: Humana Press; 71-77.
6. 6. Ali M, Lemonine N, Ring CJA. 1994 The use of DNA viruses as vectors for gene therapy. Gene Ther. 1:367-384.
7. 7. Anderson WF. 1998 Human gene therapy. Nature. 392(Suppl):25-30.
8. 8. Kaneko S, Hallenbeck P, Kotani T, et al. 1995 Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res. 55:5283-5287.
9. 9. Vincent AJPE, Vogels R, Someren GV, et al. 1996 Herpes simples virus thymidine kinase gene therapy for rat malignant brain tumors. Hum Gene Ther. 7:197-205.
10. 10. Elshami AA, Kucharczuk JC, Zhang HB, et al. 1996 Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simples virus thymidine kinase gene. Hum Gene Ther. 7:141-148.
11. 11. Vincent AJ, Esandi MC, Avezaat CJ, et al. 1997 Preclinical testing of recombinant adenoviral herpes simplex virus-thymidine kinase gene therapy for central nervous system malignancies. Neurosurgery. 41:442-451.
12. 12. Block A, Chen SH, Kosai K, Finegold M, Woo SL. 1997 Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors. Pancreas. 15:25-34.
13. 13. Ross HM, Hirschowitz EA, Russi TJ, et al. 1997 Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo. J Surg Res. 70:7-11.
14. 14. Lefevre C, Imagawa M, Dana S, Grindlay J, Bodner M, Karin M. 1987 Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. EMBO J. 6:971-981.
15. 15. Lira SA, Crenshaw EB, Glass CK, Swanson LW, Rosenfeld MG. 1988 Identification of rat growth hormone genomic sequences targeting pituitary expression in transgenic mice. Proc Natl Acad Sci USA. 85:4755-4759.
16. 16. Schaufele F. 1994 Regulation of expression of the growth hormone and prolactin genes. In: Imura H, ed. The pituitary gland, 2nd ed. New York: Raven Press; 91-116.
17. 17. Aland ET, Windle JJ, Whyte DB, Mellon PL. 1996 Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development. 122:3319-3329.
18. 18. Kendall SK, Saunders TL, Jin L, et al. 1991 Targeted ablation of pituitary gonadotropes in transgenic mice. Mol Endocrinol. 5:2025-2036.
19. 19. Swaminathan S, Thimmapaya B. 1996 Transactivation of adenovirus E2-early promoter by E1A and E4 6/7 in the context of viral chromosome. J Mol Biol. 258:736-746.
20. 20. Borrelli E, Heyman RA, Arias C, Sawchenko PE, Evans RM. 1989 Transgenic mice with inducible dwarfism. Nature. 339:538-541.
21. 21. Cattini PA, Peritz LN, Anderson TR, Baxter JD, Eberhardt NL. 1986 The 5'-flanking sequences of the human growth hormone gene contain a cell specific control element. DNA. 5:503-509.
22. 22. Kendall SK, Gordon DF, Birkmeier TS, et al. 1994 Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone α-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland. Mol Endocrinol. 8:1420-1433.
23. 23. Sarapura VD, Wood WM, Gordon DF, Ocran KW, Kao MY, Ridgway EC. 1990 Thyrotrope expression and thyroid hormone inhibition map to different regions of the mouse glycoprotein hormone α-subunit gene promoter. Endocrinology. 127:1352-1361.
24. 24. Pennathur S, Madison LD, Kay TW, Jameson JL. 1993 Localization of promoter sequences required for thyrotropin-releasing hormone and thyroid hormone responsiveness of the glycoprotein hormone α-gene in primary cultures of rat pituitary cells. Mol Endocrinol. 7:797-805.
25. 25. Horn F, Windle JJ, Barnhart KM, Mellon PL. 1992 Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific protein. Mol Endocrinol. 6:2143-2153.
26. 26. Chedrese PJ, Kay TW, Jameson JL. 1994 Gonadotropin-releasing hormone stimulates glycoprotein hormone alpha-subunit messenger ribonucleic acid (mRNA) levels in α T3 cells by increasing transcription and mRNA stability. Endocrinology. 134:2475-2481.
27. 27. Kim DS, Ahn SK, Yoon JH, et al. 1994 Involvement of a cAMP-responsive DNA element in mediating TRH responsiveness of the human thyrotropin alpha-subunit gene. Mol Endocrinol. 8:528-536.
28. 28. Gurr JA, Kourides IA. 1989 Regulation of the transfected human glycoprotein hormone alpha-subunit gene by dexamethasone and thyroid hormone. DNA. 8:473-480.
29. 29. Yarwood NJ, Gurr JA, Sheppard MC, Franklyn JA. 1993 Estradiol modulates thyroid hormone regulation of the human glycoprotein hormone α subunil gene. J Biol Chem. 268:21984-21989.
30. 30. Windle JJ, Weiner RI, Mellon PL. 1990 Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol. 4:597-603.
31. 31. Roberson MS, Schoderbek WE, Tremml G, Maurer RA. 1994 Activation of the glycoprotein hormone α-subunit promoter by a LIM-homeodomain transcription factor. Mol Cell Biol. 14:2985-2993.
32. 32. Tremblay JJ, Lanctot C, Drouin J. 1998 The pan-pituitary activator of transcription, Ptxl (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Mol Endocrinol. 12:428-441.
33. 33. Oppenheim DS, Kana AR, Sangha JS, Klibanski A. 1990 Prevalence of α-subunit hypersecretion in patients with pituitary tumors: clinically nonfunctioning and somatotroph adenomas. J Clin Endocrinol Metab. 70:859-864.
34. 34. Ishibashi M, Yamaji T, Takaku F, Teramoto A, Fukushima T. 1987 Secretion of glycoprotein hormone α-subunit by pituitary tumors. J Clin Endocrinol Metab. 64:1187-1193.
35. 35. Furuhata S, Kameya T, Tsuruta T, Naritaka H, Toya S. 1994 Colocalization of growth hormone (GH) and glycoprotein subunit α in GH-producing pituitary adenomas in acromegalic patients. Acta Neuropathol. 87:568-571.
36. 36. Hofland LJ, van Koetsveld PM, Verleun TM, Lamberts SW. 1989 Glycoprotein hormone α-subunit and prolactin release by cultured pituitary adenoma cells from acromegalic patients: correlation with GH release. Clin Endocrinol (Oxf). 30:601-611.
37. 37. Osamura RY, Watanabe K. 1987 Immunohistochemical colocalization of growth hormone (GH) and α subunit in human GH secreting pituitary adenomas. Virchows Arch A Pathol Anat Histopathol. 411:323-330.
38. 38. Smallridge RC, Smith CE. 1983 Hyperthyroidism due to thyrotropin-secreting pituitary tumors. Diagnostic and therapeutic considerations. Arch Intern Med. 143:503-507.
39. 39. Smee DF, Boehme R, Chernow M. 1985 Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl) guanine and acyclovir in herpes simplex virus-infected and uninfected cells. Biochem Pharmacol. 34:1049-1056.
40. 40. Mattews T, Boehme R. 1988 Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 10:S490-S494.
41. 41. Mooten FL. 1986 Tumor chemosensitivity conferred by inserted herpes thymidine kinase gene: paradigm for a prospective cancer control strategy. Cancer Res. 46:5276-5281.
42. 42. Jones N, Shenk T. 1979 Isolation of adenovirus type 5 host range deletion mutants defective for transformation in rat embryo cells. Cell. 17:683-689.
43. 43. Zhang Y, Schneider RJ. 1994 Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network. J Virol. 68:2544-2555.
44. 44. Valentine RC, Pereira HG. 1965 Antigens and structure of the adenovirus. J Mol Biol. 13:13-20.
45. 45. Brough DE, Lizonova A, Hsu C, Kulesa VA, Kovesdi I. 1996 A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4. J Virol. 70:6497-6501.
46. 46. Ketner G, Bridge E, Virtanen A, Hemstrom C, Pettersson U. 1989 Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids. Nucleic Acids Res. 17:3037-3048.
47. 47. Bridge E, Ketner G. 1990 interaction of adenoviral E4 and E1b products in late gene expression. Virology. 174:345-353.
48. 48. Chen WY, Chen N, Yun J, Wagner TE, Kopchick JJ. 1994 In vitro and in vivo studies of the antagonistic effects of human growth hormone analogs. J Biol Chem. 269:15892-15897.