Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: Focus on Alzheimer's disease and age-related cataracts

Novartis Foundation Symposium

Volumn 235, Issue , 2001, Pages 26-43

  Bush, Ashley I ^a   Goldstein, Lee E ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METALLOPROTEIN;

AGING; ALZHEIMER DISEASE; CATARACT; CHRONIC DISEASE; DEGENERATIVE DISEASE; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

AGING; ALZHEIMER DISEASE; CATARACT; CHRONIC DISEASE; HUMANS; METALLOPROTEINS; NEURODEGENERATIVE DISEASES; OXIDATION-REDUCTION;

EID: 0035229653     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (85)

1. Aquilina JA, Carver JA, Truscott RJ 1999 Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine. Biochemistry 38:11455-11464
2. Atwood CS, Moir RD, Huang X et al 1998 Dramatic aggregation of Alzheimer Aβ by Cu (II) is induced by conditions representing physiological acidosis. J Biol Chem 27:12817-12826
3. Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI 1999 Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Met Ions Biol Syst 36:309-364
4. Atwood CS, Huang X, Khatri A et al 2000a Copper catalyzed oxidation of Alzheimer Aβ. Cell Mol Biol (Noisy-Le-Grand) 46:777-783
5. Atwood CS, Scarpa RC, Huang X et al 2000b Characterization of copper interactions with Alzheimer amyloid β peptides: identification of an attomolar-affinity copper binding site on amyloid β1-42. J Neurochem 75:1219-12133
6. Augusteyn RC, Koretz JF 1987 A possible structure for a-crystallin. FEBS Lett 222:1-5.
7. Balaji M, Sasikala K, Ravindran T 1992 Copper levels in human mixed, nuclear brunescence, and posterior subcapsular cataract. Br J Ophthalmol 76:668-669
8. Benavente MG, Truscott RJ 1991 Modification of proteins by 3-hydroxyanthranilic acid: the role of lysine residues. Arch Biochem Biophys 290:451-457
9. B-crystallin exists as an independent protein in the heart and in the lens. Eur J Biochem 202:775-781
10. Bhuyan KC, Bhuyan DK, Podos SM 1986 Lipid peroxidation in cataract of the human. Life Sci 38:1463-1471
11. Brown DR, Wong BS, Hafiz F, Clive C, Haswell SJ, Jones IM 1999 Normal prion protein has an activity like that of superoxide dismutase. Biochem J 344:1-5 (erratum: 2000 Biochem J 345:767)
12. Bruijn LI, Houseweart MK, Kato S et al 1998 Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science 281:1851-1854
13. Bush AI 2000 Metals and neuroscience. Curr Opin Chem Biol 4:184-191
14. Bush AI, Multhaup G, Moir RD et al 1993 A novel zinc (II) binding site modulates the function of the βA4 amyloid protein precursor of Alzheimer's disease. J Biol Chem 268:16109-16112
15. Bush AI, Pettingell WH, Jr., Paradis MD, Tanzi RE 1994 Modulation of Aβ adhesiveness and secretase site cleavage by zinc. J Biol Chem 269:12152-12158
16. Bush AI, Lynch T, Cherny RC et al 1999 Alzheimer Aβ functions as a superoxide antioxidant in vitro and in vivo. Soc Neurosci Abstr 25:14
17. Calhoun ME, Wiederhold KH, Abramowski D et al 1998 Neuron loss in APP transgenic mice. Nature 395:755-756.
18. Carver JA, Aquilina JA, Cooper PG, Williams GA, Truscott RJ 1994 α-crystallin: molecular chaperone and protein surfactant. Biochim Biophys Acta 1204:195-206
19. Cekic O 1998 Effect of cigarette smoking on copper, lead, and cadmium accumulation in human lens. Br J Ophthalmol 82:186-188
20. Chen YC, Reid GE, Simpson RJ, Truscott RJ 1997 Molecular evidence for the involvement of α-crystallin in the colouration/cross-linking of crystallins in age-related nuclear cataract. Exp Eye Res 65:835-840
21. Cherny RA, Legg JT, McLean CA et al 1999 Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion. J Biol Chem 274:23223-23228
22. Cook CS, McGahan MC 1986 Copper concentration in cornea, iris, normal, and cataractous lenses and intraocular fluids of vertebrates. Curr Eye Res 5:69-76
23. Crow JP, Sampson JB, Zhuang Y, Thompson JA, Beckman JS 1997 Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite. J Neurochem 69:1936-1944
24. Cuajungco MP, Lees GJ 1997 Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis 4:137-169
25. Cuajungco MP, Goldstein LE, Nunomura A et al 2000 Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc. J Biol Chem 275:19439-19442
26. Davies MJ, Fu S, Wang H, Dean RT 1999 Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radic Biol Med 27:1151-1163
27. Dean RT, Fu S, Stocker R, Davies MJ 1997 Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 324:1-18
28. Dilley KJ, Pirie A 1974 Changes to the proteins of the human lens nucleus in cataract. Exp Eye Res 19:59-72
29. Ehrenwald E, Chisolm GM, Fox PL 1994 Intact human ceruloplasmin oxidatively modifies low density lipoprotein. J Clin Invest 93:1493-1501
30. Estevez AG, Crow JP, Sampson JB et al 1999 Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 286:2498-2500
31. Fecondo JV, Augusteyn RC 1983 Superoxide dismutase, catalase and glutathione peroxidase in the human cataractous lens. Exp Eye Res 36:15-23
32. Flanagan EM, Erickson JB, Viveros OH, Chang SY, Reinhard JF Jr 1995 Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis. J Neurochem 64:1192-1196
33. Frausto da Silva JJR, Williams RJP 1991 The biological chemistry of the elements. Clarendon Press, Oxford
34. Goldstein LE, Leopold MC, Huang X et al 2000 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote α-crystallin cross-linking by metal ion reduction. Biochemistry 39:7266-7275
35. Gonzalez C, Martin T, Cacho J et al 1999 Serum zinc, copper, insulin and lipids in Alzheimer's disease ε4 apolipoprotein E allele carriers. Eur J Clin Invest 29:637-642
36. Groenen PJ, Merck KB, de Jong WW, Bloemendal H 1994 Structure and modification of the junior chaperone α-crystallin. From lens transparency to molecular pathology. Eur J Biochem 225:1-19
37. Gutteridge JM 1987 Bleomycin-detectable iron in knee-joint fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin. Biochem J 245:415-421
38. Halliwell B, Gutteridge JM 1984 Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219:1-14
39. Halliwell B, Gutteridge JM, Blake D 1985 Metal ions and oxygen radical reactions in human inflammatory joint disease. Philos Trans R Soc Lond B Biol Sci 311:659-671
40. Harding JJ 1972 Conformational changes in human lens proteins in cataract. Biochem J 129:97-100
41. Harding JJ 1998 Cataract, Alzheimer's disease, and other conformational diseases. Curr Opin Opthalmol 9:3-10
42. Hartter DE, Barnea A 1988 Brain tissue accumulates 67copper by two ligand-dependent saturable processes. A high affinity, low capacity and a low affinity, high capacity process. J Biol Chem 263:799-805
43. Heyes MP, Saito K, Jacobowitz D, Markey SP, Takikawa O, Vickers JH 1992 Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain. FASEB J 6:2977-2989
44. Heyes MP, Saito K, Major EO, Milstien S, Markey SP, Vickers JH 1993 A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-cholorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain 116:1425-1450
45. Horwitz J 1992 α-crystallin can function as a molecular chaperone. Proc Natl Acad Sci USA 89:10449-10453
46. Huang X, Atwood CS, Moir RD et al 1997 Zinc-induced Alzheimer's Aβ1-40 aggregation is mediated by conformational factors. J Biol Chem 272:26464-26470
47. Huang X, Cuajungco MP, Atwood CS et al 1999a Cu (II) potentiation of Alzheimer Aβ neurotocity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 274:37111-37116
48. Huang X, Atwood CS, Hartshorn MA et al 1999b The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 38:7609-7616
49. Kang J, Lemaire HG, Unterbeck A et al 1987 The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736
50. Kong J, Xu Z 1998 Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci 18:3241-3250
51. Lee JY, Mook-Jung I, Koh JY 1999 Histochemically reactive zinc in plaques of the Swedish mutant β-amyloid precursor protein transgenic mice. J Neurosci (online) 19:RC10
52. Lin J 1997 Pathophysiology of cataracts: copper ion and peroxidation in diabetics. Jpn J Ophthalmol 41:130-137
53. Lovell MA, Robertson JD, Teesdale WJ, Campbell JL, Markesbery WR 1998 Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci 158:47-52
54. Lyons TJ, Liu H, Goto JJ et al 1996 Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behaviour of the protein. Proc Natl Acad Sci USA 93:12240-12244
55. Mathias RT, Riquelme G, Rae JL 1991 Cell to cell communication and pH in the frog lens. J Gen Physiol 98:1085-1103
56. Micelli-Ferrari T, Vendemiale G, Grattagliano I et al 1996 Role of lipid peroxidation in the pathogenesis of myopic and senile cataract. Br J Ophthalmol 80:840-843
57. Moir RD, Atwood CS, Romano DM et al 1999 Differential effects of apolipoprotein E isoforms on metal-induced aggregation of Aβ using physiological concentrations. Biochemistry 38:4595-4503
58. Multhaup G, Schlicksupp A, Hesse L et al 1996 The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I). Science 271:1406-1409
59. Munn DH, Zhou M, Attwood JT et al 1998 Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281:1191-1193
60. Nath R, Srivastava SK, Singh K 1969 Accumulation of copper and inhibition of lactate dehydrogenase activity in human senile cataractous lens. Indian J Exp Biol 7:25-26
61. Ogawa T, Matson WR, Beal MF et al 1992 Kynurenine pathway abnormalities in Parkinson's disease. Neurology 42:1702-1706
62. Pearson SJ, Reynolds GP 1992 Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease. Neurosci Lett 144:199-201
63. Racz P, Erdohelyi A 1988 Cadmium, lead and copper concentrations in normal and senile cataractous human lenses. Ophthalmic Res 20:3-10
64. Rae TD, Schmidt PJ, Pufahl RA, Culotta VC, O'Halloran TV 1999 Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase. Science 284:805-808
65. Ramachandran S, Morris SM, Devamanoharan P, Henein M, Varma SD 1991 Radio-isotopic determination of hydrogen peroxide in aqueous humor and urine. Exp Eye Res 53:503-506
66. Rasi V, Costantini S, Moramarco A et al 1992 Inorganic element concentrations in cataractous human lenses. Ann Ophthalmol 24:459-464
67. Reynolds GP, Pearson SJ 1989 Increased brain 3-hydroxykynurenine in Huntington's disease. Lancet 2:979-980
68. Rogers KM, Augusteyn RC 1978 Glutathione reductase in normal and cataractous human lenses. Exp Eye Res 27:719-721
69. Sanni LA, Thomas SR, Tattam BN et al 1998 Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria. Am J Pathol 152:611-619
70. Sardar AM, Bell JE, Reynolds GP 1995 Increased concentrations of the neurotoxin 3-hydroxykynurenine in the frontal cortex of HIV-1-positive patients. J Neurochem 64:932-935
71. Spector A 1984 Oxidation and cataract. In: Human cataract formation. Pitman, London (Ciba Found Symp 106) p 48-64
72. Srivastava VK, Varshney N, Pandey DC 1992 Role of trace elements in senile cataract. Acta Ophthalmol (Copenh) 70:839-841
73. Stadtman ER 1993 Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions. Annu Rev Biochem 62:797-821
74. Stadtman ER, Oliver CN 1991 Metal-catalyzed oxidation of proteins. Physiological consequences. J Biol Chem 266:2005-2008
75. Starkebaum G, Harlan JM 1986 Endothelial cell injury due to copper-catalysed hydrogen peroxide generation from homocysteine. J Clin Invest 77:1370-1376
76. Stutchbury GM, Truscott RJ 1993 The modification of proteins by 3-hydroxykynurenine. Exp Eye Res 57:149-155
77. Sun SW, Jensen KB, Jensen MS et al 2000 Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Res 852:274-278
78. Taylor MW, Feng GS 1991 Relationship between interferon-γ, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 5:2516-2522
79. Van Heyningen R 1971 Fluorescent glucoside in the human lens. Nature 230:393-394
80. Van Heyningen R 1973 Assay of fluorescent glucosides in the human lens. Exp Eye Res 15:121-126
81. Viles JH, Cohen FE, Prusiner SB, Goodin DB, Wright PE, Dyson HJ 1999 Copper binding to the prion protein: structural implications of four identical cooperative binding sites. Proc Natl Acad Sci USA 96:2042-2047
82. Wood AM, Truscott RJ 1993 UV filters in human lenses: tryptophan catabolism. Exp Eye Res 56:317-325
83. Wood AM, Truscott RJ 1994 Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation. Vision Res 34:1369-1374
84. Yankner BA, Duffy LK, Kirschner DA 1990 Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250:279-282
85. Yoshida R, Urade Y, Tokuda M, Hayaishi O 1979 Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection. Proc Natl Acad Sci USA 76:4084-4086