Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

Molecular Human Reproduction

Volumn 7, Issue 12, 2001, Pages 1133-1142

  Hirst, Claire E ^a   Buzza, Marguerite S ^a   Sutton, Vivien R ^b   Trapani, Joseph A ^b   Loveland, Kate L ^a   Bird, Phillip I ^a  

^a MONASH UNIVERSITY   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Extracellular matrix remodelling; Granzyme B; Perforin; Proteinase inhibitor 9 (PI 9); Serpin

Indexed keywords

CELL PROTEIN; GRANZYME B; PERFORIN; PROTEINASE INHIBITOR;

ADULT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GRANULE; CELL MATURATION; CELL MIGRATION; CHILDBIRTH; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; ENZYME RELEASE; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; FEMALE; GERM CELL; HUMAN; HUMAN TISSUE; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOCYTE ACTIVATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOCYTE; STAINING; SYNCYTIOTROPHOBLAST; TARGET CELL; TESTIS CELL; TISSUE SECTION;

EID: 0035215769     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/7.12.1133     Document Type: Article

References (64)

1. Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition
2. Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis
3. The peptide loop consisting of amino acids 139-157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse
4. Occurrence of both urokinase and tissue plasminogen activator in human seminal plasma
5. Matrix metalloproteinases-9 in preterm and term human parturition
6. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid
7. Granzyme B and perforin lytic proteins are expressed in CD34+ peripheral blood progenitor cells mobilized by chemotherapy and granulocyte colony-stimulating factor
8. Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
9. Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1
10. Dipeptidyl peptidase I is enriched in granules of in vitro- and in vivo-activated cytotoxic T lymphocytes
11. Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin
12. The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting a role in bystander cell protection during an immune response
13. Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes
14. Evidence for cross-talk between Sertoli and germ cells using selected cathepsins as markers
15. Transcription of granzyme A and B genes is differentially regulated during lymphoid ontogeny
16. The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes
17. Proteases and antiproteases in the seminiferous tubule
18. Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes
19. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
20. Factors of the plasminogen activator system in human testis, as demonstrated by in-situ hybridization and immunohistochemistry
21. Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues
22. Granzyme B-mediated cytochrome c release is regulated by the bcl-2 family members bid and Bax
23. Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes
24. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
25. Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors
26. Expression of tissue type and urokinase type plasminogen activators as well as plasminogen activator inhibitor type-1 and type-2 in human and rhesus monkey placenta
27. Structure of a serpin-protease complex shows inhibition by deformation
28. Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro
29. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae
30. Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome
31. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
32. Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins
33. Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood
34. Secretion of plasminogen activators by Sertoli cell enriched cultures
35. Biochemical studies on dipeptidyl peptidases I to IV of the human placenta
36. Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A
37. Localization of follistatin in the rat testis
38. Cultured stem cells from human testicular teratomas: The nature of human embryonal carcinoma and its comparison with two types of yolk-sac carcinoma
39. Analysis of cell-differentiation lineage in human teratomas using new monoclonal antibodies to cytostructural antigens of embryonal carcinoma cells
40. Isolation and characterization of a multipotent clone of human embryonal carcinoma cells
41. Binding of granzyme B in the nucleus of target cells. Recognition of an 80-kilodalton protein
42. Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity
43. Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis
44. Human dipeptidyl-peptidase I. Gene characterization, localization, and expression
45. Secretion of tissue inhibitors of matrix metalloproteinases by human fetal membranes, decidua and placenta at parturition
46. Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis
47. Role of proteases in implantation
48. Purification of a factor from the granules of a rat natural killer cell line (RNK) that reduces tumor cell growth and changes tumor morphology. Molecular identity with a granule serine protease (RNKP-1)
49. Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization
50. Plasminogen activator: The identification of an additional proteinase at the outer acrosomal membrane of human and boar spermatozoa
51. Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I
52. Granzymes: A variety of serine protease specificities encoded by genetically distinct subfamilies
53. Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris
54. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
55. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
56. Importance of the P4′ residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the PI-9 reactive center loop
57. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
58. The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)
59. Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes
60. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
61. Gene expression of plasminogen activation cascade components in human term gestational tissues with labour onset
62. Characterization of human interleukin 2 receptor (Tac antigen) in normal and leukemic T cells: Co-expression of normal and aberrant receptors on Hut-102 cells
63. Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7
64. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells