The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses

Cellular Immunology

Volumn 210, Issue 1, 2001, Pages 21-29

  Buzza, Marguerite S ^a   Hirst, Claire E ^a   Bird, Catherina H ^a   Hosking, Patrick ^b   McKendrick, Joseph ^b   Bird, Phillip I ^a  

^a MONASH UNIVERSITY   (Australia)

^b BOX HILL HOSPITAL   (Australia)

Author keywords

Apoptosis; Bystander cell; Cytotoxic lymphocyte; Endothelial cell; Granzyme B; Mesothelial cell; PI 9; Serpin

Indexed keywords

GRANZYME B; MESSENGER RNA; PHORBOL ESTER; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR 9; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL NUCLEUS; CELL PROTECTION; CELLULAR DISTRIBUTION; CYTOSOL; CYTOTOXIC LYMPHOCYTE; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MESOTHELIUM CELL; PLEURA EFFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UMBILICAL VEIN;

EID: 0035946841     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2001.1806     Document Type: Article

References (39)

1. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalise granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
2. Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte induced apoptosis
3. Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7
4. Granzyme B short circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid
5. Granzyme B-mediated cytochrome C release is regulated by the bcl-2 family members bid and bax
6. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
7. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
8. Structure of a serpin-protease complex shows inhibition by deformation
9. Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against enzyme B mediated apoptosis without perturbing the Fas cell death pathway
10. Involvement of two distinct killing mechanisms in bystander target cell lysis induced by a cytotoxic T lymphocyte clone
11. Extracellular granzymes A and B in humans: Detection of native species during CTL responses in vitro and in vivo
12. The serpin proteinase inhibitor 9 is an endogenous inhibitor of the interleukin 1β-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
13. Immunobiology of human vascular endothelium
14. Pathophysiology of pleural space infections
15. Immunopurification of a functional Asp-ase (natural killer granzyme B) using a monoclonal antibody
16. Large vessel endothelial isolation
17. Characterization of a spontaneously transformed human endothelial cell line
18. Isolation, characterization and long term culture of human myometrial microvascular endothelial cells
19. Expression and purification of recombinant human granzyme B from Pichia Pastoris
20. A cobblestone cell isolated from the human omentum: The mesothelial cell; isolation, identification, and growth characteristics
21. Identification of endothelial and mesothelial cells in human omental tissue and omentum derived cultured cells by specific cell markers
22. Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion
23. Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage-CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1
24. Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells
25. Regulation of IL-1-stimulated GMCSF mRNA levels in human endothelium
26. Protein kinase C regulates MHC-class II expression on endothelial cells
27. Characteristics and growth patterns of human peritoneal mesothelial cells: Comparison between advanced epithelial ovarian cancer and non-ovarian cancer sources
28. Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes
29. Expression of cytolytic mediators by synovial fluid lymphocytes in rheumatoid arthritis
30. Soluble granzymes are released during human endotoxemia and in patients with severe infection due to Gramnegative bacteria
31. Lysis of bystander target cells after triggering of human cytotoxic T lymphocytes
32. Self recognition by T cells. I. Bystander killing of target cells bearing syngeneic MHC antigen
33. + cytotoxic T cell (CTL) clones: Implications for CTL lytic mechanisms
34. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, refilling of the lytic granules and secretion of lytic proteins via a non-granule pathway
35. Secretion of MCP-1 and IL-6 by cytokine stimulated production of reactive oxygen species in endothelial cells
36. Pleural mesothelial cell expression of C-C (monocyte chemotactic peptide) and C-X-C (interleukin-8) chemokines
37. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production
38. 2+ mobilization, and enzyme release
39. Nucleocytoplasmic distribution of the Ovalbumin serpin PI-9 requires a non-conventional nuclear import pathway and the export factor Crm1