Gap junctions are involved in the early generation of left-right asymmetry

Developmental Biology

Volumn 203, Issue 1, 1998, Pages 90-105

  Levin, Michael ^a   Mercola, Mark ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Connexins; Gap junctions; Heterotaxia; Laterality; Left right asymmetry

Indexed keywords

GAP JUNCTION PROTEIN;

ARTICLE; CELL SPECIFICITY; EMBRYO; EMBRYO DEVELOPMENT; GAP JUNCTION; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; XENOPUS;

VERTEBRATA;

EID: 0032212639     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1998.9024     Document Type: Article

References (66)

1. Britz-Cunningham, S., Shah, M., Zuppan, C., and Fletcher, W. (1995). Mutations of the connexin-43 gap-junction gene in patients with heart malformations and defects of laterality. New Engl. J. Med. 332, 1323-1329.
2. Brown, N., and Wolpert, L. (1990). The development of handedness in left/right asymmetry. Development 109, 1-9.
3. Bruzzone, R., White, T., and Goodenough, D. (1996a). The cellular Internet: On-line with connexins. Bioessays 18, 709-718.
4. Bruzzone, R., White, T. W., and Paul, D. L. (1996b). Connections with connexins: The molecular basis of direct intercellular signaling. Eur. J. Biochem. 238, 1-27.
5. Burn, J. (1991). Disturbance of morphological laterality in humans. CIBA Found. Symp. 162, 282-296.
6. Burt, J. (1991). Modulation of cardiac gap junction channel activity by the membrane lipid environment. In "Biophysics of Gap Junction Channels" (C. Peracchia, Ed.), pp. 75-93. CRC Press, Boston.
7. Casey, B., and Ballabio, A. (1995). Connexin43 mutations in sporadic and familial defects of laterality. New Engl. J. Med. 333, 941.
8. Chanson, M., Bruzzone, R., Bosco, D., and Meda, P. (1989). Effects of n-alcohols on junctional coupling and amylase secretion of pancreatic acinar cells. J. Cell. Physiol. 139, 147-156.
9. Collignon, J., Varlet, I., and Robertson, E. (1996). Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381, 155-158.
10. Cuniff, C., Jones, K., Jones, M., Saunders, B., Shepard, T., and Benirschke, K. (1988). Laterality defects in conjoined twins: Implications for normal asymmetry in human embryogenesis. Am. J. Med. Genet. 31, 669-677.
11. Dale, L., and Slack, J. (1987). Fate map for the 32-cell stage of Xenopus laevis. Development 100, 279-296.
12. Danos, M., and Yost, H. (1995). Linkage of cardiac left-right asymmetry and dorsal-anterior development in Xenopus. Development 121, 1467-1474.
13. Danos, M., and Yost, H. (1996). Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. Dev. Biol. 177, 96-103.
14. Davidson, J. S., and Baumgarten, I. M. (1988). Glycyrrhetinic acid derivatives: A novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships. J. Pharmacol. Exp. Ther. 246, 1104-1107.
15. Davies, T. C., Barr, K. J., Jones, D. H., Zhu, D., and Kidder, G. M. (1996). Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev. Genet. 18, 234-243.
16. deLaat, S., Tertoolen, L., Dorresteijn, A., and Biggelaar, J. v. d. (1980). Intercellular communication patterns are involved in cell determination in early molluscan development. Nature 287, 546-548.
17. Ewart, J. L., et al. (1997). Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene. Development 124, 1281-1292.
18. Flagg-Newton, J. L., and Loewenstein, W. R. (1980). Asymmetrically permeable membrane channels in cell junction. Science 207, 771-773.
19. Fraser, S., Green, C., Bode, H., and Gilula, M. (1987). Selective disruption of gap junctional communication interferes with a patterning process in hydra. Science 237, 49-55.
20. Fujinaga, M. (1996). Development of sidedness of asymmetric body structures in vertebrates. Int. J. Dev. Biol. 41, 153-186.
21. Gebbia, M., Towbin, J. A., and Casey, B. (1996). Failure to detect connexin43 mutations in 38 cases of sporadic and familial heterotaxy. Circulation 94, 1909-1912.
22. Giaume, C., Tabernero, A., and Medina, J. M. (1997). Metabolic trafficking through astrocytic gap junctions. Glia 21, 114-123.
23. Goldberg, G., Moreno, A., Bechberger, J., Hearn, S., Shivers, R., MacPhee, D., Zhang, Y., and Naus, C. (1996). Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative. Exp. Cell Res. 222, 48-53.
24. Goodenough, D. A., Goliger, J. A., and Paul, D. L. (1996). Connexins, connexons, and intercellular communication. Annu. Rev. Biochem. 65, 475-502.
25. Guthrie, S. (1984). Patterns of junctional communication in the early amphibian embryo. Nature 311, 149-151.
26. Guthrie, S., and Gilula, N. (1989). Gap junctional communication and development. Trends Neurosci. 12, 12-16.
27. Guthrie, S., Turin, L., and Warner, A. (1988). Patterns of junctional communication during development of the early amphibian embryo. Development 103, 769-783.
28. Hotary, K. B., and Robinson, K. R. (1994). Endogenous electrical currents and voltage gradients in Xenopus embryos and the consequences of their disruption. Dev. Biol. 166, 789-800.
29. Hotz-Wagenblatt, A., and Shalloway, D. (1993). Gap junctional communication and neoplastic transformation. Crit. Rev. Oncogen. 4, 541-558.
30. Krutovskikh, V., and Yamasaki, H. (1997). The role of gap junctional intercellular communication (GJIC) disorders in experimental and human carcinogenesis. Histol. Histopathol. 12, 761-768.
31. Lazrak, A., Peres, A., Giovannardi, S., and Peracchia, C. (1994). Ca-mediated and independent effects of arachidonic acid on gap junctions and Ca-independent effects of oleic acid and halothane. Biophys. J. 67, 1052-1059.
32. Levin, M. (1997). Left-right asymmetry in vertebrate embryogenesis. BioEssays 19, 287-296.
33. Levin, M., Johnson, R., Stern, C., Kuehn, M., and Tabin, C. (1995). A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82, 803-814.
34. Levin, M., and Mercola, M. (1998). The evolutionary conservation of mechanisms upstream of asymmetric Nodal expression: Reconciling chick and Xenopus. Dev. Genet., in press.
35. Levin, M., and Nascone, N. (1997). Two models of initial LR determination. Med. Hypoth. 49, 429-435.
36. Levin, M., Pagan, S., Roberts, D., Cooke, J., Kuehn, M., and Tabin, C. (1997). Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo. Dev. Biol. 189, 57-67.
37. Levin, M., Roberts, D., Holmes, L., and Tabin, C. (1996). Laterality defects in conjoined twins. Nature 384, 321.
38. Lo, C. W. (1996). The role of gap junction membrane channels in development. J. Bioenerg. Biomembr. 28, 379-385.
39. Lohr, J., Danos, M. C., and Yost, H. J. (1997). Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures duirng Xenopus development. Development 124, 1465-1472.
40. Lowe, L., Supp, D., Sampath, K., Yokoyama, T., Wright, C., Potter, S., Overbeek, P., and Kuehn, M. (1996). Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 381, 158-161.
41. Marx, J. L. (1981). Electric currents may guide development. Science 211, 1147-1149.
42. Mathias, R. T., Rae, J. L., and Baldo, G. J. (1997). Physiological properties of the normal lens. Physiol. Rev. 77, 21-50.
43. McCain, E., and McClay, D. (1994). The establishment of bilateral asymmetry in sea urchin embryos. Development 120, 395-404.
44. Metcalf, M., and Borgens, R. (1994). J. Exp. Zool. 268, 322-338.
45. Nascone, N., and Mercola, M. (1997). Organizer induction determines left-right asymmetry in Xenopus. Dev. Biol. 189, 68-78.
46. Nedergaard, M. (1994). Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 263, 1768-1771.
47. Nieuwkoop, P. D., and Faber, J. (1967). "Normal Table of Xenopus laevis (Daudin)," 2nd ed. North-Holland, Amsterdam.
48. Olson, D., and Moon, R. (1992). Distinct effects of ectopic expression of Wnt-1, activin B, and bFGF on gap junctional permeability in 32-cell Xenopus embryos. Dev. Biol. 151, 204-212.
49. Omori, Y., Mesnil, M., and Yamasaki, H. (1996). Connexin 32 mutations from X-linked Charcot-Marie-Tooth disease patients: Functional defects and dominant negative effects. Mol. Biol. Cell 7, 907-916.
50. Palmer, J., and Slack, C. (1970). Some bio-electric parameters of early Xenopus embryos. J. Embryol. Exp. Morphol. 24, 535-553.
51. Paul, D., Yu, K., Bruzzone, R., Gimlich, R., and Goodenough, D. (1995). Expression of a dominant negative inhibitor of intercellular communication in the early Xenopus embryo causes delamination and extrusion of cells. Development 121, 371-381.
52. Reaume, A. G., De Sousa, P. A., Kilkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., and Rossant, J. (1995). Cardiac malformation in neonatal mice lacking connexin43. Science 267, 1831-1834.
53. Robinson, S. R., Hampson, E. C., Munro, M. N., and Vaney, D. I. (1993). Unidirectional coupling of gap junctions between neuroglia. Science 262, 1072-1074.
54. Saez, J., Connor, J., Spray, D., and Bennett, M. (1989). Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate and to calcium ions. Proc. Natl. Acad. Sci. USA 86, 2708-2712.
55. Sampath, K., Cheng, A., Frisch, A., and Wright, C. (1997). Functional differences among Xenopus nodal-related genes in left-right axis determination. Development 124, 3293-3302.
56. Shi, R., and Borgens, R. B. (1994). Embryonic neuroepithelial sodium transport, the resulting physiological potential, and cranial development. Dev. Biol. 165, 105-116.
57. Shi, R., and Borgens, R. B. (1995). Three-dimensional gradients of voltage during development of the nervous system as invisible coordinates for the establishment of embryonic pattern. Dev. Dyn. 202, 101-114.
58. Takens-Kwak, B., Jongsma, H., Rook, M., and VanGinneken, A. (1992). Mechanism of heptanol-induced uncoupling of cardiac gap junctions: A perforated patch-clamp study. Am. J. Physiol. 262, C1531-C1538.
59. Ubeda, A., Trillo, M. A., House, D. E., and Blackman, C. F. (1995). Melatonin enhances junctional transfer in normal C3H/10T1/2 cells. Cancer Lett. 91, 241-245.
60. Venance, L., Piomelli, D., Glowinski, J., and Giaume, C. (1995). Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature 376, 590-594.
61. White, T., and Bruzzone, R. (1996). Multiple connexin proteins in single intercellular channels: Connexin compatibility and functional consequences. J. Bioenerg. Biomembr. 28, 339-350.
62. Winer-Muram, H. (1995). Adult presentation of heterotaxic syndromes and related complexes. J. Thoracic Imag. 10, 43-57.
63. Wood, W. (1997). Left-right asymmetry in animal development. Annu. Rev. Cell Dev. Biol. 13, 53-82.
64. Woodruff, R. I., and Telfer, W. H. (1980). Electrophoresis of proteins in intercellular bridges. Nature 286, 84-86.
65. Yamasaki, H., Mesnil, M., Omori, Y., Mironov, N., and Krutovskikh, V. (1995). Intercellular communication and carcinogenesis. Mutat. Res. 333, 181-188.
66. Zahs, K., and Newman, E. (1997). Asymmetric gap junctional coupling between glial cells in the rat retina. Glia 20, 10-22.