The role of the brachyury gene in heart development and left-right specification in the mouse

Mechanisms of Development

Volumn 79, Issue 1-2, 1998, Pages 29-37

  King, Tim ^a   Beddington, Rosa S P ^b   Brown, Nigel A ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Brachyury; Heart looping; Left right asymmetry; Lefty; Nodal; Situs

Indexed keywords

ARTICLE; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; HEART DEVELOPMENT; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FETAL PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEART DEFECTS, CONGENITAL; MICE; MICE, MUTANT STRAINS; MYOCARDIUM; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

VERTEBRATA;

EID: 0032432959     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00166-X     Document Type: Article

References (35)

1. Beddington, R,S., Rashbass, P., Wilson, V., 1992. Brachyury - a gene affecting mouse gastrulation and early organogenesis. Development (Suppl.), 157-165.
2. Biben, C., Harvey, R.P., 1997. Homeodomain factor Nkx2-5 controls left/ right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev. 11, 1357-1369.
3. Brown, N.A., Anderson R.H., 1998. Symmetry and laterality in the human heart: developmental implications. In: Harvey, R., Rosenthal, N. (Eds.), Heart Development. Academic Press, New York, pp. 447-461.
4. Chiang, C., Litingtung, Y., Lee, E., Young, K.E., Corden, J.L., Westphal, H., Beachy, P.A., 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.
5. Collignon, J., Varlet, I., Robertson, E.J., 1996. Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381, 155-158.
6. Danos, M.C., Yost, H.J., 1996. Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. Dev. Biol. 177, 96-103.
7. Franco, D., Kelly, R., Lamers, W.H., Buckingham, M., Moorman, A.F.M., 1997. Regionalized transcriptional domains of myosin light chain 3f transgenes in the embryonic mouse heart: Morphogenetic implications. Dev. Biol. 188, 17-33.
8. Halpern, M.E., Hatta, K., Amacher, S.L., Talbot, W.S., Yan, Y.L., Thisse, B., Thisse, C., Postlethwait, J.H., Kimmel, C.B., 1997. Genetic interactions in zebrafish midline development. Dev. Biol. 187, 154-170.
9. Harvey, R.P., 1998. Links in the left/right axial pathway. Cell 94, 273-276.
10. Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., Ish-Horowicz, D., 1995. Expression of a Delta homologue in prospective neurons in the chick. Nature 375, 787-790.
11. Hyatt, B.A., Yost, H.J., 1998. The left-right coordinator: The role of Vg1 in organising left-right axis formation. Cell 93, 37-46.
12. Kispert, A., Koschorz, B., Herrmann, B.G., 1995. The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J. 14, 4763-4772.
13. Layton, W.M. Jr., Manasek, F.J., 1980. Cardiac looping in early iv/iv mouse embryos. In: Van Praagh, R., Takao, A. (Eds.), Etiology and Morphogenesis of Congenital Heart Disease. Futura, New York, pp. 109-127.
14. Levin, M., Johnson, R.L., Stern, C.D., Kuehn, M., Tabin, C., 1995. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82, 803-814.
15. Levin, M., Pagan, S., Roberts, D.J., Cooke, J., Kuehn, M.R., Tabin, C.J., 1997. Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo. Dev. Biol. 189, 57-67.
16. Levin, M., Mercola, M., 1998. The compulsion of chirality: Toward an understanding of left-right asymmetry. Genes Dev. 12, 763-769.
17. Logan, M., Pagan-Westphal, S.M., Smith, D.M., Paganessi, L., Tabin, C.J., 1998. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell 94, 307-317.
18. Lohr, J.L., Danos, M.C., Yost, H.J., 1997. Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development. Development 124, 1465-1472.
19. Lowe, L.A., Supp, D.M., Sampath, K., Yokoyama, T., Wright, C.V., Potter, S.S., Overbeek, P., Kuehn, M.R., 1996. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 381, 158-161.
20. Matzuk, M.M., Kumar, T.R., Bradley, A., 1995. Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 374, 356-360.
21. Melloy, P.G., Ewart, J.L., Cohen, M.F., Desmond, M.E., Kuehn, M.R., Lo, C.W., 1998. No turning, a mouse mutation causing left-right and axial patterning defects. Dev. Biol. 193, 77-89.
22. Meno, C., Saijoh, Y., Fujii, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y., Hamada, H., 1996. Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature 381, 151-155.
23. Meno, C., Ito, Y., Saijoh, Y., Matsuda, Y., Tashiro, K., Kuhara, S., Hamada, H., 1997. Two closely related left-right asymmetrically expressed genes, lefty-1 and lefty-2: Their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells 2, 513-525.
24. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, O., Noji, S., Kondoh, H., Hamada, H., 1998. lefty-1 Is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94, 287-297.
25. Nomura, M., Li, E., 1998. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 393, 786-790.
26. Oh, S.P., Li, E., 1997. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11, 1812-1826.
27. Pagan-Westphal, S.M., Tabin, C.J., 1998. The transfer of left-right positional information during chick embryogenesis. Cell 93, 25-35.
28. Piedra, M.E., Icardo, J.M., Albajar, M., Rodnguez-Rey, J.C., Ros, M.A., 1998. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell 94, 319-324.
29. Rashbass, P., Wilson, V., Rosen, B., Beddington, R.S., 1994. Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos. Int. J. Dev. Biol. 38, 35-44.
30. Ryan, A.K., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Pena, J., Sabbagh, W., Greenwald, J., Choe, S., Noms, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G., Izpisua-Belmonte, J.C., 1998. Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 394, 545-551.
31. Seo, J.-W., Brown, N.A., Ho, S.Y., Anderson, R.H., 1992. Abnormal laterality and congenital cardiac anomalies. Relations of visceral and cardiac morphologies in the iv/iv mouse. Circulation 86, 642-650.
32. St. Amand, T.R., Ra, J., Zhang, Y., Hu, Y., Baber, S.I., Qui, M.S., Chen, Y.P., 1998. Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic looping. Biochem. Biophys. Res. Commun. 247, 100-105.
33. Supp, D.M., Witte, D.P., Potter, S.S., Brueckner, M., 1997. Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature 389, 963-966.
34. Yoshioka, H., Meno, C., Koshiba, K., Sugihara, M., Itoh, H., Ishimaru, Y., Inoue, T., Ohuchi, H., Semina, E.V., Murray, J.C., Hamada, H., Noji, S., 1998. Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94, 299-305.
35. Weinstein, D.C., Ruiz i Altaba, A., Chen, W.S., Hoodless, P., Prezioso, V.R., Jessell, T.M., Darnell, J.E. Jr., 1994. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell 78, 575-588.