Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis

International Immunology

Volumn 13, Issue 12, 2001, Pages 1541-1550

  Wedderburn, Lucy R ^a   Patel, Alka ^a   Varsani, Hemlata ^a   Woo, Patricia ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autoimmunity; Clonotype; Expansion; Heteroduplex; HLA B27; HLA DRB1; Human; Juvenile idiopathic arthritis memory; TCR

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA B27 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ALLELE; ANTIGEN PRESENTATION; ARTHRITIS; ARTICLE; BIODIVERSITY; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLONE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DNA POLYMORPHISM; ENTHESITIS; FEMALE; GENE LOCUS; GENETIC CODE; HELPER CELL; HLA SYSTEM; HUMAN; HUMAN CELL; INFLAMMATORY CELL; JOINT; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOLECULAR RECOGNITION; PATHOGENESIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RISK; SYNOVIUM; T LYMPHOCYTE SUBPOPULATION;

EID: 0035214004     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.12.1541     Document Type: Article

References (55)

1. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997
2. Juvenile chronic arthritis-a time for change?
3. Transmission disequilibrium as a test of linkage and association between HLA alleles and pauciarticular-onset juvenile rheumatoid arthritis
4. Ankylosing spondylitis and HL-A 27
5. T cell receptor V beta usage in synovial fluid of children with arthritis
6. T cell receptor rearrangements in juvenile rheumatoid arthritis: A search for oligoclonality
7. + clones in juvenile rheumatoid arthritis
8. Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: Evidence for antigenic selection of T cells in the synovium
9. Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood
10. + subset in normal human subjects
11. + T-cell population. Analysis using a multiplex PCR assay for CDR3 length
12. T-cell clonality in immune responses
13. Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype
14. An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations
15. + population
16. The developing T cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T cell expansions
17. Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis
18. Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis
19. + cells in human cytomegalovirus and other viral infections
20. + T cells in acute infectious mononucleosis
21. Independent regulation of lymphocytic choriomeningitis virus-specific T cell memory pools: Relative stability of CD4 memory under conditions of CD8 memory T cell loss
22. Limited heterogeneity of T cell receptor variable region gene usage in juvenile rheumatoid arthritis synovial T cells
23. Analysis of T cell receptor gamma transcripts in right and left knee synovial fluids of patients with rheumatoid arthritis
24. Patterns of T lymphocyte clonal expansion in HLA-typed patients with juvenile rheumatoid arthritis
25. + T cells in rheumatoid arthritis
26. + T cell populations prepared directly from rheumatoid synovium
27. + T cell clones in the synovial fluid of patients with rheumatoid arthritis
28. Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings
29. + T cells in severe rheumatoid arthritis
30. T cell homeostasis in patients with rheumatoid arthritis
31. Thymic activity in rheumatoid arthritis is dependent on disease factor such as inflammation
32. Multiple T cell expansions are found in the blood and synovial fluid of patients with reactive arthritis
33. Common intra-articular T cell expansions in patients with reactive arthritis: Identical beta-chain junctional sequences and cytotoxicity toward HLA-B27
34. Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven
35. + monozygotic twins
36. CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response
37. Juvenile rheumatoid arthritis and the trimolecular complex (HLA, T cell receptor, and antigen). Differences from rheumatoid arthritis
38. Restricted T cell receptor expression by human T cell clones specific for mycobacterial 65-kDa heat-shock protein: Selective in vivo expansion of T cells bearing defined receptors
39. HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segments. A study in patients with reactive arthritis
40. A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis
41. Evaluating candidate autoantigens in rheumatoid arthritis
42. The role of T cells in the immunopathogenesis of rheumatoid arthritis: New perspectives
43. Pathogenesis and mechanisms of inflammation in the childhood rheumatic diseases
44. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry
45. Antigen-independent activation of resting T-cells in the liver of patients with chronic hepatitis
46. Interferon-beta mediates stromal cell rescue of T cells from apoptosis
47. Persistence of memory CD8 T cells in MHC class I-deficient mice
48. Class II-independent generation of CD4 memory T cells from effectors
49. Effect of IL15 on T cell clonality in vitro and in the synovial fluid of patients with rheumatoid arthritis
50. Interleukin-15 up-regulates the expression of CD154 on synovial fluid T cells
51. + memory T cells by opposing cytokines
52. Differential survival of naive CD4 and CD8 T cells
53. + T cells
54. Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure
55. Jekyll and Hyde: The transformation of HLA-B27