A Single Nonamer from the Yersinia 60-kDa Heat Shock Protein Is the Target of HLA-B27-Restricted CTL Response in Yersinia-Induced Reactive Arthritis

Journal of Immunology

Volumn 159, Issue 11, 1997, Pages 5715-5723

  Ugrinovic, Sanja ^a,b   Mertz, Andreas ^a   Wu, Peihua ^b   Braun, Jürgen ^a   Sieper, Joachim ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; EPITOPE; HEAT SHOCK PROTEIN; HLA B27 ANTIGEN; PEPTIDE FRAGMENT;

ARTICLE; CD8+ T LYMPHOCYTE; CELL LINE; CHEMISTRY; CYTOLOGY; CYTOTOXIC T LYMPHOCYTE; HUMAN; IMMUNOLOGY; INFECTIOUS ARTHRITIS; MICROBIOLOGY; SYNOVIAL FLUID; YERSINIA;

ARTHRITIS, INFECTIOUS; BACTERIAL PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; EPITOPES; HEAT-SHOCK PROTEINS; HLA-B27 ANTIGEN; HUMANS; PEPTIDE FRAGMENTS; SYNOVIAL FLUID; T-LYMPHOCYTES, CYTOTOXIC; YERSINIA;

EID: 0031303865     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Brewerton, D. A., F. D. Hart, A. Nicholls, M. Caffrey, D. C. James, and R. D. Sturrock. 1973. Ankylosing spondylitis and HL-A 27. Lancet 1:904.
2. Brewerton, D. A., M. Caffrey, A. Nicholls, D. Walters, J. K. Oates, and D. C. James. 1973. Reiter's disease and HL-A 27. Lancet 2:996.
3. Dougados, M., S. van der Linden, R. Juhlin, B. Huitfeldt, B. Amor, A. Calin, A. Cats, B. Dijkmans, I. Olivieri, G. Pasero, E. Veys, and H. Zeidler. 1991. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum. 34:1218.
4. Sieper, J., and J. Braun. 1995. Pathogenesis of spondylarthropathies: persistent bacterial antigen, autoimmunity, or both? Arthritis Rheum. 38:1547.
5. Leirisalo-Repo, M., K. Laasila, P. Helenius, and M. Nissilä. 1996. Epidemiology and prognostic features of reactive arthritis. Ann. Rheum. Dis. 55:576.
6. Nikkari, S., R. Merilahti-Palo, R. Saario, K. O. Söderstöm, K. Granfors, M. Skurnik, and P. Toivanen. 1992. Yersinia-triggered reactive arthritis: use of polymerase chain reaction and immunocytochemical staining in the detection of bacterial components from synovial specimens. Arthritis Rheum. 35:682.
7. Taylor Robinson, D., C. B. Gilroy, B. J. Thomas, and A. C. Keat. 1992. Detection of Chlamydia trachomatis DNA in joints of reactive arthritis patients by polymerase chain reaction. Lancet 340:81.
8. Sieper, J., and G. Kingsley. 1996. Recent advances in the pathogenesis of reactive arthritis. Immunol. Today 17:160.
9. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287.
10. Benjamin, R., and P. Parham. 1990. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol. Today 11:137.
11. Autenrieth, I. B., A. Tingle, A. Reske Kunz, and J. Heesemann. 1992. T lymphocytes mediate protection against Yersinia enterocolitica in mice: characterization of murine T-cell clones specific for Y. enterocolitica. Infect. Immun. 60: 1140.
12. Magee, D. M., D. M. Williams, J. G. Smith, C. A. Bleicker, B. G. Grubbs, J. Schachter, and R. G. Rank. 1995. Role of CD8 T cells in primary Chlamydia infection. Infect. Immun. 63:516.
13. + T cells which can proliferate in vitro and mediate delayed-type hypersensitivity reactivity. Immunology 81:183.
14. Ramsey, K. H., and R. G. Rank. 1991. Resolution of chlamydial genital infection with antigen-specific T-lymphocyte lines. Infect. Immun. 59:925.
15. Hermann, E., D. T. Yu, K. H. Meyer zum Buschenfelde, and B. Fleischer. 1993. HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 342:646.
16. Pfeifer, J. D., M. J. Wick, R. L. Roberts, K. Findlay, S. J. Normark, and C. V. Harding. 1993. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361:359.
17. + T lymphocyte-mediated lysis of Chlamydia-infected L cells using an endogenous antigen pathway. J. Immunol. 153:4588.
18. Starnbach, M. N., M. J. Bevan, and M. F. Lampe. 1994. Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis. J. Immunol. 153:5183.
19. k) mice. Arthritis Rheum. 40:945.
20. Rock, K. L. 1996. A new foreign policy: MHC class I molecules monitor the outside world. Immunol. Today 17:131.
21. Mertz, A. K., A. Daser, M. Skurnik, K. H. Wiesmuller, J. Braun, H. Appel, S. Batsford, P. Wu, A. Distler, and J. Sieper. 1994. The evolutionarily conserved ribosomal protein L23 and the cationic urease beta-subunit of Yersinia enterocolitica O:3 belong to the immunodominant antigens in Yersinia-triggered reactive arthritis: implications for autoimmunity. Mol. Med. 1:44.
22. Mertz, A., R. Lauster, J. Braun, and J. Sieper. 1996. Synovial T cell response to the heat shock protein HSP 60 of Yersinia enterocolitica in Yersinia-arthritis patients. Arthritis Rheum. 39:S299.
23. Kingsley, G., and J. Sieper. 1996. Meeting report: third international workshop on reactive arthritis. Ann. Rheum. Dis. 55:564.
24. Sieper, J., G. Kingsley, A. Palacios Boix, C. Pitzalis, J. Treharne, R. Hughes, A. Keat, and G. S. Panayi. 1991. Synovial T lymphocyte-specific immune response to Chlamydia trachomatis in Reiter's disease. Arthritis Rheum. 34:588.
25. Starnbach, M. N., and M. J. Bevan. 1994. Cells infected with Yersinia present an epitope to class I MHC-restricted CTL. J. Immunol. 153:1603.
26. Noll, A., and I. B. Autenrieth. 1996. Yersinia-hsp60-reactive T cells are efficiently stimulated by peptides of 12 and 13 amino acid residues in a MHC class II (I-Ab)-restricted manner. Clin. Exp. Immunol. 105:231.
27. Jardetzky, T. S., W. S. Lane, R. A. Robinson, D. R. Madden, and D. C. Wiley. 1991. Identification of self peptides bound to purified HLA-B27. Nature 353:326.
28. Madden, D. R., J. C. Gorga, J. S. Strominger, and D. C. Wiley. 1992. The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Cell 70:1035.
29. Daser, A., H. Urlaub, and P. Henklein 1994. HLA-B27 binding peptides derived from the 57 kD heat shock protein of Chlamydia trachomatis: novel insights into the peptide binding rules. Mol. Immunol. 31:331.
30. Rötzschke, O., K. Falk, S. Stefanovic, V. Gnau, G. Jung, and H. G. Rammensee. 1994. Dominant aromatic/aliphatic C-terminal anchor in HLA-B*2702 and HLA-B*2705 peptide motifs, Immunogenetics 39:74.
31. Tonigaki, N., D. Fruci, E. Vigneti, G. Starace, P. Rovero, M. Londei, R. H. Butler, and R. Tosi. 1994. The peptide binding specificity of HLA-B27 subtypes. Immunogenetics 40:192.
32. Aidoo, M., A. Lalvani, C. E. Allsopp, M. Plebanski, S. J. Meisner, P. Krausa, M. Browning, S. Morris Jones, F. Gotch, D. A. Fidock, M. Takiguchi, K. J. H. Robson, and et al. 1995. Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria. Lancet 345:1003.
33. Hill, A. V., J. Elvin, A. C. Willis, M. Aidoo, C. E. Allsopp, F. M. Gotch, X. M. Gao, M. Takiguchi, B. M. Greenwood, A. R. Townsend, A. J. McMichael, and H. C. Whittle. 1992. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360:434.
34. + T cells specific for single nonamer epitope of Listeria monocytogenes are protective in vivo. J. Exp. Med. 175:1531.
35. Van Bleek, G. M., and S. G. Nathenson. 1990. Isolation of an endogenously processed immunodominant viral peptide from the class I H-2Kb molecule. Nature 348:213.
36. + cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 348:245.
37. Falk, K., O. Rotzschke, S. Stefanovic, G. Jung, and H. G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
38. Noll, A., A. Roggenkamp, J. Heesemann, and I. B. Autenrieth. 1994. Protective role for heat shock protein-reactive alpha beta T cells in murine yersiniosis. Infect. Immun. 62:2784.
39. Silva, C. L., M. F. Silva, R. C. Pietro, and D. B. Lowrie. 1996. Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infect. Immun. 64:2400.
40. Oldstone, M. B., M. Nerenberg, P. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65:319.
41. Kaufmann, S. H. E. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol 11:129.
42. Scofield, R. H., B. Kurien, T. Gross, W. L. Warren, and J. B. Harley. 1995. HLA-B27 binding of peptide from its own sequence and similar peptides from bacteria: implication for spondyloarthropathies. Lancet 345:1542.
43. Garcia, F., A. Marina, P. Albar, and J. A. Lopez de Castro. 1997. HLA-B27 presents a peptide from a polymorphic region of its own molecule with homology to proteins from arthritogenic bacteria. Tissue Antigens 49:23.
44. Selin, L. K., S. R. Nahill, and R. M. Welsh. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179: 1933.
45. Zugel, U., B. Schoel, S. Yamamoto, H. Hengel, B. Morein, and S. H. Kaufmann. 1995. Cross-recognition by CD8 T cell receptor alpha beta cytotoxic T lymphocytes of peptides in the self and the mycobacterial hsp60 which share intermediate sequence homology. Eur. J. Immunol. 25:451.
46. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
47. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
48. Burmester, G. R., A. Daser, T. Kamradt, A. Krause, N. A. Mitchison, J. Sieper, and N. Wolf. 1995. Immunology of reactive arthritides. Annu. Rev. Immunol. 13:229.
49. Altman, J. D., P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94.
50. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanism and roles in the T cell biology. Annu. Rev. Immunol. 14:1.