Common intra-articular T cell expansions in patients with reactive arthritis: Identical β-chain junctional sequences and cytotoxicity toward HLA-B27

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 3830-3839

  Dulphy, Nicolas ^a   Peyrat, Marie Alix ^a   Tieng, Vannary ^a   Douay, Corinne ^a   Rabian, Claire ^a   Tamouza, Ryad ^a   Laoussadi, Saddek ^b   Berenbaum, Francis ^c   Chabot, Agnes ^d   Bonneville, Marc ^a   Charron, Dominique ^a   Toubert, Antoine ^a,e  

^a INSERM   (France)

^b Inst Natl S et de la Rech Med Unit 463 Institut de Biologie ^*  (France)

^c HÔPITAL SAINT ANTOINE   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B27 ANTIGEN;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; CHILD; CHLAMYDIA TRACHOMATIS; CLINICAL ARTICLE; FEMALE; HLA TYPING; HUMAN; IMMUNOPATHOGENESIS; MALE; MOLECULAR MIMICRY; PRIORITY JOURNAL; REACTIVE ARTHRITIS; SHIGELLA SONNEI; SYNOVIAL FLUID; T LYMPHOCYTE ACTIVATION; YERSINIA ENTEROCOLITICA;

EID: 0033120067     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Dougados, M., S. van der Linden, R. Juhlin, B. Huitfeldt, B. Amor, A. Calin, A. Cals, B. Dijkmans, I. Olivieri, G. Pasero, et al. 1991. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum. 34:1218.
2. Brown, M., and P. Wordsworth. 1997. Predisposition factors to spondylarthropathies. Curr. Opin. Rheumatol. 9:308.
3. Taurog, J., J. A. Richardson, J. T. Croft, W. A. Simmons, M. Zhou, J. L. Femandez-Sueiro, E. Balish, and R. E. Hammer. 1994. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180:2359.
4. 2-microglobulin: a model of human spondyloarthropathies. J. Exp. Med. 182:1153.
5. Madden, D. R., J. C. Gorga, J. L. Strominger, and D. C. Wiley. 1991. The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature 353:321.
6. Lopez de Castro, J. A. 1998. The pathogenic role of HLA-B27 in chronic arthritis. Curr. Opin. Immunol. 10:59.
7. Hermann, E., D. T. Y. Yu, K. H. Meyer zum Büschenfelde, and B. Fleischer. 1993. HLA-B27 restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 342:646.
8. Branigan, P. J., H. C. Gérard, A. P. Hudson, and H. R. Schumacher, Jr. 1996. Comparison of synovial tissue and synovial fluid as the source of nucleic acids for the detection of Chlamydia trachomatis by polymerase chain reaction. Arthritis Rheum. 39:1740.
9. Nikkari, S., T. Möttönen, R. Saario, U. Yli-Kerttula, M. Leirisalo-Repo, P. Laitio, and P. Toivanen. 1996. Demonstration of Salmonella DNA amplification in the synovial fluid in reactive arthritis. Arthritis Rheum. 39:S185 (Abstr.).
10. Mertz, A. K. H., S. Ugrinovic, R. Lauster, P. Wu, M. Grolms, U. Böttcher, H. Appel, Z. Yin, E. Schiltz, S. Batsford, et al. 1998. Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis. Arthritis Rheum. 41:315.
11. Gaston, J. S., K. H. Deane, R. M. Jecock, and J. H. Pearce. 1996. Identification of two Chlamydia trachtomatis antigens recognized by synovial fluid T cells from patients with Chlamydia induced reactive arthritis. J. Rheumatol. 23:130.
12. Ugrinovic, S., A. Mertz, P. Wu, J. Braun, and J. Sieper. 1997. A single nonamer from the Yersinia 60-kDa heal shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis. J. Immunol. 159:5715.
13. Struyk, L., G. E. Hawes, M. K. Chatila, F. C. Breedveld, J. T. Kurnick, and P. van den Elsen. 1995. T-cell receptors in rheumatoid arthritis. Arthritis Rheum. 5:577.
14. Lim, A., A. Toubert, C. Pannetier, M. Dougados, D. Charron, P. Kourilsky, and J. Even. 1996. Spread of clonal T-cell expansions in rheumatoid arthritis patients. Hum. Immunol. 48:77.
15. Kato, T., M. Kurokawa, K. Masuko-Hongo, H. Sasakawa, T. Sekine, S. Ueda, K. Yamamoto, and K. Nishioka. 1997. T cell clonality in synovial fluid of a patient with rheumatoid arthritis. J. Immunol. 159:5143.
16. Verjans, G. M. G. M., U. N. A. Klaren, M. Leirisalo-Repo, J. H. Ringrose, H. Repo, A. Steinle, C E. M. van Doornik, and T. E. W. Fellkamp. 1996. Heterogeneity of rearranged T cell receptors Va and Vβ gene transcripts in synovial fluid T cells of HLA-B27 positive reactive arthritis patients. Clin. Rheumatol. 15:91.
17. Allen, R. L., G. M. Gillespie, F. Hall, S. Edmonds, M. A. Hall, B. P. Wordsworth, A. J. McMichael, and P Bowness. 1997. Multiple T cell expansions are found in the blood and synovial fluid of patients with reactive arthritis. J. Rheumatol. 24:1750.
18. Duchmann, R., E. May, B. Ackermann, B. Goergen, K. H. Meyer zum Buschenfelde, and E. Märker-Hermann. 1996. HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria of self-antigens are dominated by closely related TCRBV gene segments: a study in patients with reactive arthritis. Scand. J. Immunol. 43:101.
19. May, E., R. Duchmann, B. Ackermann, K. H. Meyer zum Büschenfelde, and E. Marker-Hermann. 1996. TCRB junctional regions from HLA-B27-restricted T cells and HLA-B27 binding peptides display conserved hydropathy profiles in the absence of primary sequence homology. Int. Immunol. 11:1815.
20. Garboczi, D., P. Ghost, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley, 1996 Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
21. Maslanka, K. T. Piatek, J. Gorski, M. Yassai, and J. Gorski. 1995. Molecular analysis of T cell repertoires. Spectratypes generated by multiplex polymerase chain reaction and evaluated by radioactivity or fluorescence. Hum. Immunol. 44:28.
22. Pannetier, C., M. Cochet, S. Darche, A. Casrouge, M. Zöller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad Sci. USA 90:4319.
23. Even, J., A. Lim, I. Puisieux, L. Ferradini, P. Y. Dietrich, A. Toubert, T. Hercend, F. Triebel, C. Pannetier, and P. Kourilsky. 1995. T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: evidence for oligoclonal expansions in tumours and inflammatory diseases. Res. Immunol. 146:65.
24. Garcia, C. O., S. Paira, R. Burgos, J. Molina, J. F. Molina, C. Calvo, L. Vega, L. J. Lara, A. Garcia-Kutzbach, M. L. Cuellar, et al. 1996. Detection of Salmonella DNA in synovial membrane and synovial fluid from latin american patients with reactive arthritis using the polymerase chain reaction. Arthritis Rheum. 39: S185 (Abstr.).
25. Garderet, L., N. Dulphy, C. Douay, N. Chalumeau, V. Schaeffer, M. T. Zilber, A. Lim, J. Even, N. Mooney, C. Gelin, et al. 1998. The umbilical cord blood αβ T-cell repertoire: characteristics of a polyclonal and naive but completely formed repertoire. Blood 91:340.
26. Puisieux, I., J. Even, C. Pannetier, F. Jottereau, M. Favrot, and P. Kourilsky. 1994. Oligoclonality of tumor-infiltrating lymphocytes from human melanomas. J. Immunol. 153:2807.
27. Currier, J. R., M. Yassai, M. A. Robinson, and J. Gorski. 1996. Molecular defects in TCRBV genes preclude thymic selection and limit the expressed TCR repertoire. J. Immunol. 157:170.
28. Scotet, E., J. David-Ameline, M. A. Peyrat, A. Moreau-Aubry, D. Pinczon, A. Lim, J. Even, G. Semana, J. M. Berthelot, R. Breathnach, et al. 1996. T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis. J. Exp. Med. 184:1791.
29. Cerundolo, V., K. J. Alexander, K. Anderson, C. Lamb, P. Cresswell, A. McMichael, F. Gotch, and A. Townsend. 1990. Presentation of a viral antigen controlled by a gene in the major histocompatibility complex. Nature 345:449.
30. Barnstable, C. J., W. F. Bodmer, G. Brown, G. Galfre, C. Milstein, A. F. Williams, and A. Ziegler. 1978. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens. New tools for genetic analysis. Cell 14:9.
31. Layet, C., P. LeBouteiller, C. N'Guyen, P. Mercier, F. Rosa, M. Fellous, D. Caillol, B. R. Jordan, and F. A. Lemonnier. 1984. Transformation of LMTK-cells with purified HLA class I gene. VI. Serological characterization of HLA-B7 and Aw24 molecules. Hum. Immunol. 11:31.
32. Tamouza, R., F. Marzais, R. Krishnamoorthy, C. Besmond, C. Raffoux, and D. Charron. 1997. Rapid subtyping for HLA B27 by denaturing gradient gel electrophoresis (DGGE). In HLA: Genetic Diversity of HLA. Functional and Medical Implication, D. Charron, ed. EDK, Paris, p. 345.
33. + subset in normal human subjects. J. Immunol. 151: 5762.
34. Arden, B., S. P. Clark, D. Kabelitz, and T. W. Mak. 1995. Human T-cell receptor variable gene segment families. Immunogenetics 42:455.
35. Wilbrink, B., I. M. van der Heijden, L. M. Schouls, J. D. A. van Embden, J. M. W. Hazes, F. C. Breedveld, and P. P. Tak. 1998. Detection of bacterial DNA in joint samples from patients with undifferentiated arthritis and reactive arthritis. using polymerase chain reaction with universal 16S ribosomal RNA primers. Arthritis Rheum. 41:535.
36. Kim, G., N. Tanuma, T. Kojima, K. Kohyama, Y. Suzuki, Y. Kawazoe, and Y. Matsumoto. 1998. CDR3 size spectratyping and sequencing of spectratype-derived TCR of spinal cord T cells in autoimmune encephalomyelitis. J. Immunol. 160:509.
37. Yang, Y., B. Charlton, A. Shimada, R. Dal Canto, and C. G. Fathman. 1996. Monoclonal T cells identified in early NOD islet infiltrates. Immunity 4:189.
38. Gonzales-Quintial, R., R. Baccalà, R. M. Pope, and A. N. Theofilopoulos. 1996. Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay. J. Clin. Invest. 97:1335.
39. Oksenberg, J. R., M. A. Panzara, A. B. Begovich, D. Mitchell, H. A. Erlich, R. S. Murray, R. Shimonkevitz, M. Sherritt, J. Rothbard, C. C. A. Bernard, et al. 1993. Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362:68.
40. Prisco, A., R. Troncone, G. Mazzarella, C. Gianfrani, S. Auricchio, J. Even, C. Tiberio, J. Guardiola, and P. De Berardinis. 1997. Identical T-cell receptor β chain rearrangements are present in T cells infiltrating the jejunal mucosa of untreated celiac patients. Hum. Immunol. 55:22.
41. + lymphocytes in chronic inflammatory bowel disease. J. Immunol. 157:3183.
42. + T-cell population in newly diagnosed and untreated HLA-DR2 multiple sclerosis patients. Proc. Natl. Acad. Sci. USA 93: 12461.
43. Bowness, P., P. A. H. Moss, S. Rowland-Jones, J. I. Bell, and A. J. McMichael. 1993. Conservation of T cell receptor usage by HLA-B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses. Eur. J. Immunol. 23:1417.
44. Barber, D. F., D. Lopez, and J. A. Lopez de Castro. 1995. T cell receptor diversity in alloreactive responses against HLA-B27 (B*2705) is limited by multiple-level restrictions in both a and β chains. Eur. J. Immunol. 25:2479.
45. Maryanski, J. L., J. L. Casanova, K. Falk, H. Gournier, C. Jaulin, P. Kourilsky. F. A. Lemonnier, R. Lüthy, H. G. Rammensee, O. Rötzschke, et al. 1997. The diversity of antigen-specific TCR repertoires reflects the relative complexity of epilopes recognized. Hum. Immunol. 54:117.
46. Barber, D. F., D. Obeso, R. Garcia-Hoyo, A. Villadangos, and J. A. Lopez de Castro. 1996. T-cell receptor usage in alloreactivity against HLA-B*2703 reveals significant conservation of the antigenic structure of B*2705. Tissue Antigens 47:478.
47. Wang, F., T. Ono, A. M. Kalergis, W. Zhang, T. P. DiLorenzo, K. Lim, and S. Nathenson. 1998. On defining the rules for interactions between the T cell receptor and its ligand: a critical role for a specific amino acid residue of the T cell receptor β chain. Proc. Natl. Acad. Sci. USA 95:5217.
48. Londei, M., G. F. Bottazzo, and M. Feldmann. 1985. Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 228:85.
49. Hill, A. B., S. P. Lee, J. S. Haurum, N. Murray, Q.-Y. Yao, M. Rowe, N. Signoret, A. B. Rickinson, and A. J. McMichael. 1995. Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV) nuclear antigens fail to lyse the EBV-transformed B lymphoblastoid cell lines against which they were raised. J. Exp. Med. 181:2221.
50. Pazmany, L., S. Rowland-Jones, S. Huet, A. Hill, J. Sutton, R. Murray, J. Brooks, and A. McMichael. 1992. Genetic modulation of antigen presentation by HLA-B27 molecules. J. Exp. Med. 175:361.
51. Den Haan, J. M. M., L. M. Meadows, W. Wang, J. Pool, E. Blokland, T. L. Bishop, C. Reinhardus, J. Shabanowitz, R. Offringa, D. F. Hunt, et al. 1998. The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science 279:1054.
52. Simmons, W. A., D. C. Roopenian, S. G. Summerfield, R. C. Jones, B. Galocha, G. J. Christianson, S. D. Maika, M. Zhou, S. J. Gaskell, R. S. Bordoli, et al. 1997. A new MHC locus that influences class I peptide presentation. Immunity 7:641.
53. Brown, M. A., K. D. Pile, L. G. Kennedy, D. Campbell, L. Andrew, R. March, J. L. Shatford, D. E. Weeks, A. Calin, and B. P. Wordsworth. 1998. A genome-wide screen for susceptibility loci in ankylosing spondylitis. Arthritis Rheum. 41:588.