Multiple T cell expansions are found in the blood and synovial fluid of patients with reactive arthritis

Journal of Rheumatology

Volumn 24, Issue 9, 1997, Pages 1750-1757

  Allen, Rachel L ^a,c   Gillespie, Geraldine M A ^a   Hall, Frances ^a   Edmonds, Sally ^b   Hall, M Ann ^b   Wordsworth, B Paul ^a   McMichael, Andrew J ^a   Bowness, Paul ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b WEXHAM PARK HOSPITAL   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

CD4; CD8; Monoclonal antibody; Reactive arthritis; T cell receptor; T lymphocyte

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; HLA B27 ANTIGEN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; BLOOD; CAMPYLOBACTER JEJUNI; CHLAMYDIA TRACHOMATIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; GASTROINTESTINAL INFECTION; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; NEISSERIA GONORRHOEAE; PHENOTYPE; PRIORITY JOURNAL; REACTIVE ARTHRITIS; SALMONELLA TYPHIMURIUM; SYNOVIAL FLUID; T LYMPHOCYTE; UROGENITAL TRACT INFECTION;

ADOLESCENT; ADULT; ARTHRITIS, INFECTIOUS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SYNOVIAL FLUID; T-LYMPHOCYTE SUBSETS;

EID: 0030764230     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Benjamin R, Parham P: Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today 1990;11:137-42.
2. Sieper J, Kingsley G: Recent advances in the pathogenesis of reactive arthritis. Immunol Today 1996;17:160-3.
3. Keat A, Thomas B, Dixey J, Osborn M, Sonnex C, Taylor-Robinson D: Chlamydia trachomatis and reactive arthritis: The missing link. Lancet 1987;1:72-4.
4. Lahesmaa-Rantala R, Granfors K, Isomaki H, Toivanen A: Yersinia-specific immune complexes in the synovial fluid of patients with Yersinia triggered reactive arthritis. Ann Rheum Dis 1987;46:510-4.
5. Schumacher HR, Magge S, Cherian PV, et al: Light and electron microscopic studies on the synovial membrane in Reiter's syndrome. Immunocytochemical identification of chlamydial antigen in patients with early disease. Arthritis Rheum 1988;31:937-46.
6. Granfors K, Jalkanen S, von-Essen R, et al: Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. N Engl J Med 1989;320:216-21.
7. Hammer M, Zeidler H, Klimsa S, Heesemann J: Yersinia enterocolitica in the synovial membrane of patients with Yersinia-induced arthritis. Arthritis Rheum 1990;33:1795-800.
8. Taylor-Robinson D, Gilroy CB, Thomas BJ, Keat AC: Detection of Chlamydia trachomatis DNA in joints of reactive arthritis patients by polymerase chain reaction. Lancet 1992;340:81-2.
9. Granfors K, Jalkanen S, Toivanen P, Koski J, Lindberg AA: Bacterial lipopolysaccharide in synovial fluid cells in Shigella triggered reactive arthritis (letter). J Rheumatol 1992;19:500.
10. Nikkari S, Merilahti-Palo R, Saario R, et al: Yersinia-triggered reactive arthritis. Use of polymerase chain reaction and immunocytochemical staining in the detection of bacterial components from synovial specimens. Arthritis Rheum 1992;35:682-7.
11. Bas S, Griffais R, Kvien TK, Glennas A, Melby K, Vischer TL: Amplification of plasmid and chromosome Chlamydia DNA in synovial fluid of patients with reactive arthritis and undifferentiated seronegative spondylarthropathies. Arthritis Rheum 1995;38:1005-13.
12. Hermann E, Fleischer B, Mayet WJ, Poralla T, Meyer zum Buschenfelde KH: Response of synovial fluid T cell clones to Yersinia enterocolitica antigens in patients with reactive Yersinia arthritis. Exp Immunol 1989;75:365-70.
13. Hermann E, Mayet WJ, Poralla T, Meyer zum Buschenfelde KH, Fleischer B: Salmonella-reactive synovial fluid T-cell clones in a patient with post-infectious Salmonella arthritis. Scand J Rheumatol 1990;19:350-5.
14. Hassell AB, Reynolds DJ, Deacon M, Gaston JSH, Pearce JH: Identification of T-cell stimulatory antigens of Chlamydia trachomatis using synovial fluid-derived T-cell clones. Immunology 1993;79:513-9.
15. Probst P, Hermann E, Meyer zum Buschenfelde KH, Fleischer B: Identification of the Yersinia enterocolitica urease b subunit as a target antigen for human synovial T lymphocytes in reactive arthritis. Infect Immun 1993;61:4507-9.
16. Hermann E, Yu DTY, Meyer zum Buschenfelde KH, Fleischer B: HLA-B27 restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 1993;342:646-50.
17. Duchmann R, May E, Ackermann B, Georgen B, Meyer zum Buschenfelde KH, Marker-Hermann E: HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segments. A study in patients with reactive arthritis. Scand J Immunol 1996;43:101-8.
18. Bowness P, Moss PA, Rowland-Jones S, Bell JI, McMichael AJ: Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex Class I-restricted responses. Eur J Immunol 1993;23:1417-21.
19. Kappler JW, Pullen A, Callahan J, et al: Consequences of self and foreign superantigen interaction with specific V beta elements of the murine TCR alpha beta. Cold Spring Harbor Symp Quant Biol 1989;1:401-7.
20. Romagne F, Besnardeau L, Malissen B: A versatile method to produce antibodies to human T cell receptor V beta segments: Frequency determination of human V beta 2+ T cells that react with toxic-shock syndrome toxin-1. Eur J Immunol 1992;22:2749-52.
21. Calaman SD, Carson GR, Henry LD, et al: Characterisation of monoclonal antibodies specific for the V beta 3 family of the human TCR generated using soluble TCR beta chain. J Invest Med 1993;164:233-44.
22. Maeker HT, Levy R: Prevalence of antigen receptor variants in human T cell lines and tumors. J Immunol 1989;142:1395-404.
23. Boylston AW, Borst J, Yssel H, Blanchard D, Spits H, De Vries JE: Properties of a panel of mAb which react with the human TCR of the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes. J Immunol 1986;137:741-4.
24. Posnett DN, Wang CY, Friedman SM: Inherited polymorphism of the human TCR detected by a monoclonal antibody. Proc Natl Acad Sci USA 1986;83:7888-92.
25. Callan MFC, Reyburn HT, Bowness P, et al: A method for producing monoclonal antibodies to the human TCR beta chain variable regions. Proc Natl Acad Sci USA 1993;90:10454-8.
26. Carrel S, Isler P, Schreyer M, et al: Expression on human thymocytes of the idiotype structures (Ti) from two leukemia T cell lines Jurkat and HPB-ALL. Eur J Immunol 1986;16:649-52.
27. Dellabona P, Padovan E, Casorati G, Brockhaus M, Lanzavecchia A: An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8-T cells. J Exp Med 1994;180:1171-6.
28. Bigler RD, Fisher DE, Wang CY, Rinnoy Kan EA, Kunkel HG: Idiotype-like molecules on cells of human T cell leukemia. J Exp Med 1983;158:1000-5.
29. Friedman SM, Crow MK, Tumang JR, et al: Characterisation of human T cells reactive with the mycoplasma arthritis derived superantigen (MAM): Generation of a Mab against V beta 17, the TCR gene product expressed by a large fraction of MAM-reactive human T cells. J Exp Med 1991;174:891-900.
30. Padovan E, Casorati G, Dellabona P, Meyer S, Brockhaus M, Lanzavecchia A: Expression of two T cell receptor a chains: Dual receptor T cells. Science 1993;262:422-4.
31. Posnett DN, Sinha R, Kabak S, Russo C: Clonal populations of T cells in normal elderly humans: The T cell equivalent of "benign monoclonal gammapathy." J Exp Med 1994;179:609-18.
32. Marvel J, Lightstone E, Samberg NL, Ettinghausen D, Stauss HJ: The CD45RA molecule is expressed in naive murine CTL precursors but absent in memory and effector CTL. Int J Immunol 1991;3:21-8.
33. Hoy MD, O'Donnell JL, Hart DN: Dual CD45RA, CD45RO positive T-lymphocytes within rheumatoid arthritic joints. Pathology 1993;25:167-73.
34. Callan MF, Steven N, Krausa P, et al: Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nature Medicine 1996;2:906-11.
35. Moss P, Gillespie G, Frodsham P, Bell J, Reyburn H: Clonal populations of CD4+ and CD8+ T cells in patients with multiple myeloma and paraproteinemia. Blood 1996;87:3297-306.
36. Fitzgerald JE, Ricalton NS, Meyer A-C, et al: Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol 1995;154:3539-47.
37. Nityanand S, Giscombe R, Srivastava S, et al: A bias in the ab T cell receptor variable region gene usage in Takayasu's arteritis. Clin Exp Immunol 1997;107:261-8.
38. Salmi M, Andrew DP, Butcher EC, Jalkanen S: Dual binding capacity of mucosal immunoblasts to mucosal and synovial endothelium in humans: Dissection of the molecular mechanisms. J Exp Med 1995;181:137-49.
39. Howell MD, Diveley JP, Lundeen KA, et al: Limited T-cell receptor b-chain heterogeneity among interleukin-2 receptor positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci USA 1991;88:10921-5.
40. Paliard X, West SG, Lafferty JA, et al: Evidence for the effects of a superantigen in rheumatoid arthritis. Science 1991;253:325-9.
41. Sensi M, Salvi S, Castelli C, et al: T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: Tumor-infiltrating lymphocytes overexpress in vivo the TCR beta chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone. J Exp Med 1993;178:1231-46.
42. Moss PAH, Rowland-Jones SL, Frodsham PM, et al: Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc Natl Acad Sci USA 1995;92:5773-5.
43. Choi Y, Lafferty JA, Clements JR, et al: Selective expansion of T cells expressing V beta 2 in toxic shock syndrome. J Exp Med 1990;172:981-4.
44. Lahesmaa R, Soderberg C, Bliska J, et al: Pathogen antigen- and superantigen-reactive synovial fluid T cells in reactive arthritis. J Infect Dis 1995;172:1290-7.