Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells

Gastroenterology

Volumn 114, Issue 3, 1998, Pages

  Kennedy, M ^a   Denenberg, A G ^a   Szabo, C ^a   Salzman, A L ^a   Colgan, S P ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; PEROXYNITRITE; SINGLE STRANDED DNA;

ARTICLE; CANCER CELL CULTURE; COLON CANCER; DNA STRAND BREAKAGE; ENTERITIS; HUMAN; INTESTINE MUCOSA PERMEABILITY; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0031936405     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70534-7     Document Type: Article

References (66)

1. SJ Middleton M Shorthouse JO. Hunter Increased nitric oxide synthesis in ulcerative colitis Lancet 341 1993 465 466
2. M. Guslandi Nitric oxide in ulcerative colitis Lancet 341 1993 905 906
3. M Mourelle F Casellas F Guarner A Salas V Riveros-Moreno S Moncada J-R. Malagelada Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon Gastroenterology 109 1995 1497 1502
4. VW. Yang Eicosanoids and inflammatory bowel disease Clin North Am 25 1996 317 332
5. RP. MacDermott Alterations of the mucosal immune system in inflammatory bowel disease J Gastroenterol 31 1996 906 916
6. DD Tran JJ Visser MO Pool MA Cuesta K Hoekman AS Pena SGM. Meuwissen Enhanced systemic nitric oxide production in inflammatory bowel disease Lancet 341 1993 1150
7. H Wiseman B. Halliwell Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Biochem J 313 1996 17 29
8. NK Boughton-Smith SM Evans CJ Hawkey AT Cole M Balsitis BJ Whittle S. Moncada Nitric oxide synthase activity in ulcerative colitis and Crohn's disease Lancet 342 1993 338 340
9. D Rachmilewitz JS Stamler D Bachwich F Karmeli Z Ackerman DK. Podolsky Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease Gut 36 1995 718 723
10. AL. Salzman Nitric oxide in the gut New Horizons 3 1995 352 364
11. II Singer DW Kawka S Scott JR Weidner RA Mumford TE Riehl WF. Stenson Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease Gastroenterology 111 1996 871 885
12. MB Grisham RD Specian TE. Zimmerman Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomotous colitis J Pharm Exp Ther 271 1994 1114 1121
13. MB Grisham T. Yamada Neutrophils, nitrogen oxides, and inflammatory bowel disease Ann NY Acad Sci 664 1992 103 115
14. AL Salzman AG Denenberg I Ueta M O'Connor S Linn C. Szabó Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers Am J Physiol 270 1995 G565 G573
15. SC Linn PJ Morelli I Edry SE Cottongim C Szabó AL. Salzman Transcriptional regulation of the human inducible nitric oxide synthase gene in an intestinal epithelial cell line Am J Physiol 272 1997 G1499 G1508
16. AL Salzman MJ Menconi N Unno RM Ezzell DM Casey PK Gonzales MP. Fink Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers Am J Physiol 268 1994 G361 G373
17. MJS Miller JH Thompson XJ Zhang H Sadowska-Krowicka JL Kakkis UK Munshi M Sandoval J Rossi S Elobi-Childress J Beckman YZ Ye CP Rodi P Manning M Currie DA. Clark Inducible nitric oxide synthase gene expression and peroxynitrite formation in guinea pig ileitis Gastroenterology 109 1995 1475 1483
18. C Szabó AL. Salzman Endogenous peroxynitrite is involved in the inhibition of cellular respiration in immuno-stimulated J774.2 macrophages Biochem Biophys Res Commun 209 1995 739 743
19. C. Szabó The role of peroxynitrite in the pathophysiology of shock, inflammation, and ischemia-reperfusion injury Shock 6 1996 79 88
20. C Szabó B Zingarelli AL. Salzman Peroxynitrite-mediated activation of poly-ADP ribosyl synthetase contributes to the vascular failure in shock The pathophysiology of shock: proceedings of the Third International Shock Meeting 1995 Elsevier New York
21. B Zingarelli M O'Connor AL Salzman C. Szabó Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide J Immunol 156 1996 350 358
22. C Szabó AL Salzman H. Ischiropoulos Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagtic shock and ischemia-reperfusion injury FEBS Lett 372 1995 229 232
23. C Szabó B Zingarelli M O'Connor AL. Salzman DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite Proc Natl Acad Sci USA 93 1996 1753 1758
24. C Szabó B Zingarelli AL. Salzman Role of poly-ADP ribosyltransferase activation in the nitric oxide– and peroxynitrite-induced vascular failure Circ Res 78 1996 1051 1063
25. C. Szabó DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite Free Radic Biol Med 21 1996 855 869
26. C Szabó B Zingarelli S Cuzzocrea AL. Salzman Activation of poly (ADP-ribose) synthetase is involved in the endothelial dysfunction in response to peroxynitrite and endotoxin shock (abstr) Crit Care Med 25 1996 A34
27. C. Szabó DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite Free Radic Biol Med 21 1996 855 869
28. NA. Berger Oxidant-induced cytotoxicity: a challenge for metabolic modulation Am J Respir Cell Mol Biol 4 1991 1 3
29. S Cuzzocrea B Zingarelli G Constantino A Szabó AL Salzman AP Caputi C. Szabó Beneficial effects of 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion Br J Pharmacol 121 1997 1065 1074
30. B Zingarelli S Cuzzocrea Z Zsengeller AL Salzman C. Szabó Beneficial effect of inhibition of poly-ADP ribose synthetase activity in myocardial ischemia-reperfusion injury Cardiovasc Res 36 1997 205 215
31. C Szabó LH Lim S Cuzzocrea SJ Getting B Zingarelli RJ Flower AL Salzman M. Perretti Inhibition of poly(ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment J Exp Med 186 1997 1041 1049
32. MD Peterson MS. Mooseker Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal line, Caco-2 J Cell Sci 102 1992 581 600
33. MJ Briske-Anderson JW Finley SM. Newman The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells Proc Soc Exp Med Biol 214 1997 248 257
34. V Meunier M Bourrie Y Berger G. Fabre The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications Cell Biol Toxicol 11 1995 187 194
35. PI Bauer E Kirsten G Varadi LJT Young A Hakam JA Comstock E. Kun Reversal of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone, a non-covalently binding ligand of poly (ADP-ribose) polymerase Biochimie 77 1995 347 377
36. M Banasik H Komura M Shimoyama K. Ueda Specific inhibitors of poly (ADP-ribose) synthetase and mono(ADP-ribosyl) transferase J Biol Chem 267 1992 1569 1575
37. C Szabó S Cuzzocrea B Zingarelli M O'Connor AL. Salzman Endothelial dysfunction in endotoxic shock: importance of the activation of poly (ADP ribose) synthetase (PARS) by peroxynitrite J Clin Invest 100 1997 723 735
38. N Munfakh J Steinberg J Titus D Denenberg D O'Keefe W Daggett G. Geffin Protection of the hypertrophied myocardium by crystalloid cardioplegia J Surg Res 51 1991 447 456
39. T Lowry A Rosebough A Farr R. Randall Protein measurement with the folin phenol reagent J Biochem 193 1951 265 275
40. J. Reden Molsidomine Blood Vessels 27 1990 282 294
41. IlY Haddad JP Crow P Hu Y Ye J Beckman S. Matalon Concurrent generation of nitric oxide and superoxide damages surfactant protein Am J Physiol 267 1994 L2249 L2452
42. C Szabó C Saunders M O'Connor AL. Salzman Peroxynitrite causes energy depletion and increases permeability via activation of poly-ADP ribosyl synthetase in pulmonary epithelial cells Am J Respir Mol Biol 60 1996 105 109
43. IU Schraufstatter DB Hinshaw PA Hyslop RG Spragg CG. Cochrane Oxidant injury of cells: DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide J Clin Invest 77 1986 1312 1320
44. MJ Menconi AL Salzman N Unno RM Ezzel DM Casey Y Tsuji MP. Fink Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers Am J Physiol 272 1997 G1007 G10021
45. N Unno MJ Menconi M Smith DE Aguirre MP. Fink Nitric oxide (NO)-induced derangements in the permeability of cultured intestinal epithelial monolayers: effect of low extracellular pH Am J Physiol 272 1997 G923 G934
46. T Yamada RB Sartor S Marshall RD Specian MB. Grisham Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats Gastroenterology 104 1994 759 771
47. W Pryor G. Squadrito The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide Am J Physiol 268 1995 L699 L722
48. S Dimmeler F Lottspeich B. Brüne Nitric oxide causes ADP-ribosylation and inhibition of glyceraldhyde-3-phosphate dehydrogenase J Biol Chem 267 1992 16771 16774
49. J Stadler RD Curran JB Ochoa BG Harbrecht RA Hoffman RL Simmons TR. Billiar Effect of endogenous nitric oxide on mitochondrial respiration of rat hepatcytes in vitro and in vivo Arch Surg 126 1994 186 191
50. JA Corbett JL Wang MA Sweetland JR Lancaster ML. McDaniel Interleukin 1β induces the formation of nitric oxide by B-cells purified from rodent islets of Langerhans J Clin Invest 90 1994 2384 2391
51. PR Gardner G Constantino C Szabó AL. Salzman Nitric oxide sensitivity of the aconitases J Biol Chem 272 1997 25071 25076
52. J-C Drapier JB. Hibbs Differentiation of murine macrophages to express nonspecific cytotoxicity in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells J Immunol 14 1994 2829 2838
53. I Kurose S Kato H Ishii D Fukumura S Miura M Suematsu M. Tsuchiya Nitric oxide mediates lipopolysaccharide-induced alteration of mitochondrial function in cultured hepatocytes and isolated perfused liver Hepatology 18 1993 380 388
54. N Welsh DL Eizirik K Bendtzen S. Sandler Interleukin-1β–induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase Endocrin 129 1991 3167 3173
55. L Castro M Rodriguez R. Radi Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide J Biol Chem 269 1994 29409 29415
56. A Hausladen I. Fridovich Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not J Biol Chem 269 1994 29405 29408
57. C. Szabó Role of poly (ADP-ribose) synthetase activation in suppression of cellular energetics in response to nitric oxide and peroxynitrite Biochem Soc Trans 25 1997 841 846
58. C. Szabó Nitric oxide and PARS G Rubanyi Pathophysiology and clinical applications of nitric oxide. 1998 Karger Basel, Switzerland (in press)
59. S Tamir S Burney SR. Tannenbaum DNA damage by nitric oxide Chem Res Toxicol 9 1996 821 827
60. J Zhang JP. Steiner Nitric oxide synthase, immunophyllins and poly (ADP-ribose) synthetase: novel targets for the development of neuroprotective drugs Neurol Res 17 1995 285 288
61. ZQ Wang B Auer L Sting H Berghammer D Haidacher M Schweiger EF. Wagner Mice lacking ADPRT and poly(ADP-ribosylation) develop normally but are susceptible to skin disease Genes Dev 9 1995 510 520
62. K Yamamoto K Tsukidate JL. Farber Differing effects of the inhibition of poly(ADP-ribose) polymerase on the course of exidative cell injury in hepatocytes and fibroblasts Biochem Pharmacol 46 1993 483 491
63. B Zingarelli AL Salzman C. Szabó Protective effects of nicotinamide against nitric oxide mediated vascular failure in endotoxic shock: potential involvement of poly ADP ribosyl synthetase Shock 5 1996 258 264
64. V Burkart H. Kolb Protection of islet cells from inflammatory cell death in vitro Clin Exp Immunol 93 1993 273 278
65. JB Schulz RT Matthews MM Muqit SE Browne MF. Beal Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice J Neurochem 64 1995 936 939
66. J Zhang VL Dawson TM Dawson SH. Snyder Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity Science 263 1994 687 689