Splenic NK1.1-negative, TCRβ intermediate CD4+ T cells exist in naive NK1.1 allelic positive and negative mice, with the capacity to rapidly secrete large amounts of IL-4 and IFN-γ upon primary TCR stimulation

Journal of Immunology

Volumn 162, Issue 9, 1999, Pages 5156-5163

  Moodycliffe, Angus M ^a   Maiti, Sourindra ^a   Ullrich, Stephen E ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HELPER CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION;

ALLELES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; ANTIGENS, CD3; ANTIGENS, SURFACE; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-4; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PROTEIN BIOSYNTHESIS; PROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, IGG; SPLEEN; T-LYMPHOCYTE SUBSETS;

EID: 0033136736     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Bendelac, A., M. N. Rivera, S.-H. Park, and J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535.
2. β family. Proc. Natl. Acad. Sci. USA 89:6506.
3. + cells in the liver of mice. J. Exp. Med. 180:699.
4. + cells. J. Immunol. 145:3209.
5. + T cells: a new family of T cells. Immunol. Today 17:71.
6. - T cells in mice and humans. J. Exp. Med. 180:1097.
7. + T-cell antigen receptor α chain in mice. Proc. Natl. Acad. Sci. USA 88:7518.
8. + cells: new clues to their origin, specificity, and function. J. Exp. Med. 182:633.
9. + cells. J. Immunol. 160:1158.
10. + thymocytes selected by MHC class I molecules. Science 263:1774.
11. Sato, K., K. Ohtsuka, K. Hasegawa, S. Yamagiwa, H. Watanabe, H. Asakura, and T. Abo. 1995. Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J. Exp. Med. 182:759.
12. + T lymphocytes. Science 268:863.
13. + T cell development and early IL-4 production in CD1-deficient mice. Immunity 6:459.
14. Mendiratta, S. K., W. D. Martin, S. Hong, A. Boesteanu, S. Joyce, and L. Van Kaer. 1997. CD1dl mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469.
15. - thymocytes with specific lymphokine secretion. Eur. J. Immunol. 23:307.
16. + T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1. J. Immunol. 159:2240.
17. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
18. H2 response and in immunoglobulin E production. Science 270:1845.
19. + T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. USA 92:11931.
20. Bendelac, A., R. D. Hunziker, and O. Lantz. 1996. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med. 184:1285.
21. Smiley, S. T., M. H. Kaplan, and M. J. Grusby. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275:977.
22. -. Eur. J. Immunol. 25:3298.
23. - T cell population. J. Immunol. 157:4421.
24. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184:1295.
25. 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J. Exp. Med. 184:1507.
26. +CTLs in vivo. J. Immunol. 155:2564.
27. Cui, J., T. Shin, T. Kawano, H. Sato, E. Kondo, I. Toura, Y. Kaneko, H. Koseki, M. Kanno, and M. Taniguchi. 1997. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 278:1623.
28. + thymocyte population associated with intact Fas antigen expression on the target. J. Exp. Med. 180:423.
29. Takeda, K., and G. Dennert. 1993. The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms. J. Exp. Med. 177:155.
30. + NK T cells associated with disease development in autoimmune-prone mice. J. Immunol. 156:4035.
31. + effector function against intracellular infection. J. Exp. Med. 184:131.
32. +T cells are present within a population of intermediate TCR cells. J. Immunol. 155:2972.
33. Julius, M. H., E. Simpson, and L. A. Herzenberg. 1973. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:645.
34. 2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression. J. Immunol. 160:3783.
35. + T cells upon NKR-P1 cross-linking. J. Exp. Med. 183: 2391.
36. Lynch, R. G. 1998. The biology and pathology of lymphocyte Fc receptors. Am. J. Pathol. 152:631.
37. + T cells lose NK1.1 expression upon in vitro activation. J. Immunol. 158:5112.
38. Lantz, O., L. I. Sharara, F. Tilloy, A. Andersson, and J. P. DiSanto. 1997. Lineage relationships and differentiation of natural killer (NK) T cells: intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1l and Ly49 molecules. J. Exp. Med. 185:1395.