Protective activity of aromatic amines and imines against oxidative nerve cell death

Biological Chemistry

Volumn 382, Issue 11, 2001, Pages 1601-1612

  Moosmann, B ^a   Skutella, T ^a   Beyer, K ^a   Behl, C ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Antioxidant; Cytoprotection; Free radical; Neurodegeneration; Oxidative stress; Quantitative structure activity relationship (QSAR)

Indexed keywords

(1 NAPHTHYL) PHENYLAMINE; (2 NAPHTHYL) PHENYLAMINE; 1 NAPHTHYLAMINE; 10,11 DIHYDRO 5H DIBENZ[B,F]AZEPINE; 4 BUTYLANILINE; 4 DODECYLANILINE; 4 DODECYLPHENOL; ANTIOXIDANT; AROMATIC AMINE; DIBENZAZEPINE; DIPHENYLAMINE; GLUTAMIC ACID; GLUTATHIONE; HYDROGEN PEROXIDE; IMINE; N METHYL PHENOTHIAZINE; N N DIMETHYL 1 NAPHTHYLAMINE; PHENOL DERIVATIVE; PHENOTHIAZINE; PHENOXAZINE DERIVATIVE; QUERCETIN; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCULATION; CELL CLONING; CELL CULTURE; CELL DEATH; CELL PROTECTION; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; HIPPOCAMPUS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MOUSE; NERVE CELL; NEUROPATHOLOGY; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CELL SURVIVAL; DIBENZAZEPINES; ELECTRON SPIN RESONANCE SPECTROSCOPY; HIPPOCAMPUS; HUMANS; HYDROGEN BONDING; IMINES; LIPID PEROXIDATION; MICE; NEURONS; NITROGEN; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PEROXIDES; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0035198214     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.195     Document Type: Article

References (65)

1. Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases
2. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury
3. Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches
4. Hydrogen peroxide mediates amyloid β protein toxicity
5. Oxidative stress in Huntington's disease
6. Antioxidant activity of vitamin E and related phenols: Importance of stereoelectronic factors
7. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
8. Oxidative stress and Alzheimer disease
9. Oxidative stress and motor neurone disease
10. Pathobiology of ischemic stroke: An integrated view
11. Oxidative stress and antioxidant therapy in Parkinson's disease
12. Blood-brain barrier permeation: Molecular parameters governing passive diffusion
13. Antioxidants, oxidative stress, and degenerative neurological disorders
14. Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson's disease
15. Oxidative stress-induced neurodegenerative diseases: The need for antioxidants that penetrate the blood-brain barrier
16. MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: Neuroprotective strategies
17. Vitamin E and Alzheimer disease: The basis for additional clinical trials
18. Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases
19. What transgenic mice tell us about neurodegenerative disease
20. Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: Update on a 2-year double-blind multicentre study
21. The antioxidant paradox
22. A hypothesis on the pathogenesis of Alzheimer's disease
23. Safety and tolerability of the free-radical scavenger OPC-14117 in Hungtington's disease
24. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
25. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
26. Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
27. Pathways to neuronal injury and apoptosis in HIV-associated dementia
28. Different risk factors for different stroke subtypes: Association of blood pressure, cholesterol, and antioxidants
29. Quantitative structure-activity relationship analysis of phenolic antioxidants
30. Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia
31. Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis
32. Oxidative stress in brain ischemia
33. Prion infection impairs the cellular response to oxidative stress
34. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties
35. Cytoprotective antioxidant function of tyrosine and tryptophan residues in transmembrane proteins
36. Dietary phenols: Antioxidants for the brain?
37. Antioxidants as treatment for neurodegenerative disorders
38. Neuroprotective potential of aromatic alcohols against oxidative cell death
39. Oxidative stress in Alzheimer's disease
40. Alzheimer disease: Protective factors
41. Ebselen in acute middle cerebral artery occlusion: A placebo-controlled, double-blind clinical trial
42. Friedreich's ataxia and frataxin: Molecular genetics, evolution and pathogenesis
43. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurones
44. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
45. Ebselen: Prospective therapy for cerebral ischemia
46. Multiple antioxidants in the prevention and treatment of neurodegenerative disease: Analysis of biologic rationale
47. Multiple antioxidants in the prevention and treatment of Alzheimer disease: Analysis of biologic rationale
48. Oxidative damage in the central nervous system: Protection by melatonin
49. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study
50. Molecular mechanisms of calcium-dependent excitotoxicity
51. A method to determine the ability of drugs to diffuse through the blood-brain barrier
52. Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis
53. Datatop: A decade of neuroprotective inquiry. Deprenyl and tocopherol antioxidative therapy of parkinsonism
54. Ebselen, a selenoorganic compound as glutathione peroxidase mimic
55. Glutathione and its role in cellular functions
56. Oxidative stress in neurodegenerative diseases
57. Demyelination: The role of reactive oxygen and nitrogen species
58. Ongoing trials in Alzheimer's disease
59. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells
60. Molecular pharmacology of vitamin E: Structural aspects of antioxidant activity
61. A quantum mechanical explanation of the antioxidant activity of flavonoids
62. α-Tocopherol in CSF of subjects taking high-dose vitamin E in the Datatop study
63. Mechanisms of neurodegenerative disorders: Control of cell death
64. Prion disease: A loss of antioxidant function?
65. Phenothiazines as lipid-peroxidation inhibitors and cytoprotective agents