Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study

Neurology

Volumn 50, Issue 6, 1998, Pages 1900-1902

  Vatassery, Govind T ^a,c   Fahn, Stanley ^b   Kuskowski, Michael A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Columbia University ^*  (United States)

^c VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; SELEGILINE;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG MEGADOSE; EXTRACELLULAR FLUID; HUMAN; MULTICENTER STUDY; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0031746550     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.50.6.1900     Document Type: Article

References (9)

1. Fahn S, Cohen G. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann Neurol 1992;32: 804-812.
2. The Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1993;328:176-183.
3. Shoulson I. Antioxidative therapeutic strategies for Parkinson's disease. Ann NY Acad Sci 1992;648:37-42.
4. Markwell MAK, Haas SM, Bieber LL, Tolbert NE. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem 1978;87: 206-210.
5. Vatassery GT, Smith WE, Quach HT. A liquid chromatographic method for the simultaneous determination of alpha tocopherol and tocopherolquinone in human red blood cells and other biological samples where tocopherol is easily oxidized during sample treatment. Anal Biochem 1993;214:426-430.
6. Vatassery GT, Nelson MJ, Maletta GJ, Kuskowski MA. Vitamin E (tocopherols) in human cerebrospinal fluid. Am J Clin Nutr 1991;53:95-99.
7. Horwitt MK, Harvey CC, Dahm CH Jr, Searcy MT. Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy. Ann NY Acad Sci 1972;203:223-236.
8. Pappert EJ, Tangney CC, Goetz CG, et al. Alpha tocopherol in the ventricular cerebrospinal fluid of Parkinson's patients. Neurology 1996;47:1037-1042.
9. Vatassery GT, Brin MF, Fahn S, Kayden HJ, Traber MG. Effect of high doses of dietary vitamin E on the concentrations of vitamin E in several brain regions, plasma, liver and adipose tissue of rats. J Neurochem 1988;51:621-623.