One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats

Journal of Neurotrauma

Volumn 16, Issue 2, 1999, Pages 109-122

  Dixon, C E ^a,b,c   Kochanek, P M ^a,b   Yan, H Q ^a,b   Schiding, J K ^a,b   Griffith, R G ^a,b   Baum, E ^a,b   Marion, D W ^a,b   DeKosky, S T ^a,b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cholinergic; Cortical impact; Cortical lesions; M2 muscarinic; Rat; VAChT

Indexed keywords

ACETYLCHOLINE; CARRIER PROTEIN; MUSCARINIC M2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CHOLINERGIC NERVE CELL; COGNITIVE DEFECT; CONTROLLED STUDY; CRANIOTOMY; HEMISPHERE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE TEST; NONHUMAN; PARIETAL LOBE; RAT; SPATIAL MEMORY;

EID: 0032956180     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1999.16.109     Document Type: Article

References (44)

1. ANDERSON, C.V., BIGLER, E.D., and BLATTER, D.D. (1995). Frontal lobe lesions, diffuse damage, and neuropsychological functioning in traumatic brain-injured patients. J. Clin. Exp. Neuropsychol. 17, 900-908.
2. BALDWIN, S.A., GIBSON, T., CALLIHAN, C.T., SULLIVAN, P.G., PALMER, E., and SCHEFF, S.W. (1997). Neuronal cell loss in the CA3 subfield of the hippocampus following cortical contusion utilizing the optical disector method for cell counting. J. Neurotrauma 14, 385-398.
3. BERGER-SWEENEY, J., HECKERS, S., MESULAM, M.-M., WILEY, R.G., LAPPI, D.A., and SHARMA, M. (1994). Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis rnagnocellularis. J. Neurosci. 14, 4507-4519.
4. BIGLER, E.D., BLATTER, D.D., ANDERSON, C.V., et al. (1997). Hippocampal volume in normal aging and traumatic brain injury. Am. J. Neuroradiol. 18, 11-23.
5. BRAMLETT, H.M., DIETRICH, W.D., GREEN, E.J., and BUSTO, R. (1997). Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia. Acta Neuropathol. 92, 190-199.
6. 2 muscarinic receptor protein in rats. Exp. Neurol. 152, 11-19.
7. DEKOSKY, S.T., SCHEFF, S.W., HACKNEY, C.G, and BASS, N.H. (1985). Strain differences and laminar localization of structural neurochemical changes in aging rat. Neurobiol. Aging 6, 277-286.
8. DESALLES, A.F., NEWLON, P.G., KATAYAMA, Y., et al. (1987). Transient suppression of event-related evoked potentials produced by mild head injury in the cat. J. Neurosurg. 66, 102-108.
9. 2 muscarinic receptor binding sites in temporal cortex following head injury: a preliminary human postmortem study. J. Neurotrauma 13, 181-187.
10. 3H]choline uptake but not extracellular choline levels in rats. Neurosci. Lett. 180, 127-130.
11. DIXON, C.E., CLIFTON, G.L., LIGHTHALL, L.W., YAGHMAI, A.A., and HAYES, R.L. (1991). A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39, 253-262.
12. DIXON, C.E., LIU, S.J., JENKINS, L.W., et al. (1995). Time course of increased vulnerability of cholinergic neurotransmission following traumatic brain injury in the rat. Behav. Brain Res. 70, 125-131.
13. DIXON, C.E., LYTHE, B.G., POVLISHOCK, J.T., et al. (1987). A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119.
14. DIXON, C.E., MA, X., and MARION, D.W. (1997). Reduced evoked release of acetylcholine in the rodent neocortex following traumatic brain injury. Brain Res. 749, 127-130.
15. DOW, R.S., ULETT, G., and TUNTURI, A. (1945). Electroencephalographic changes following head injuries in dogs. J. Neurophysiol. 8, 161-172.
16. FEENEY, D.M., BOYESON, M.G., LINN, R.T., MURRAY, H.M., and DAIL, W.G. (1981). Responses to cortical injury. I. Methodology and local effects of contusion in the rat. Brain Res. 211, 67-77.
17. GALE, S.D., JOHNSON, S.C., BIGLER, E.D., and BLATTER, D.D. (1995). Trauma-induced degenerative changes in brain injury: a morphometric analysis of three patients with preinjury and postinjury MR scans. J. Neurotrauma 12, 151-158.
18. GORMAN, L.K., FU, K., HOVDA, D.A., MURRAY, M., and TRAYSTMAN, R.J. (1996). Effects of traumatic brain injury on the cholinergic system in the rat. J. Neurotrauma 13, 457-463.
19. HAMM, R.J., WHITE-GBADEBO, D.M., LYETH, B.G., JENKINS, L.W., and HAYES, R.L. (1992). The effect of age on motor and cognitive deficits after traumatic brain injury in rats. Neurosurgery 31, 1072-1078.
20. HOFFMAN, S.W., FULOP, Z., and STEIN, D.G. (1994). Bilateral frontal contusion in the rat: behavioral and anatomic consequences. J. Neurotrauma 11, 417-431.
21. ISHIGE, N., PITT, L.H., BERRY, I., et al. (1987). The effect of hypoxia on traumatic head injury in rats: alterations in neurologic function, brain edema, and cerebral blood flow. J. Cereb. Blood Flow Metab. 7, 759-767.
22. KATAYAMA, Y., REUTHER, S., DIXON, C.E., BECKER, D.P., and HAYES, R.L. (1985). Dissociation of endogenous components of auditory evoked potentials following carbachol microinjection into the cholinoceptive pontine inhibitory area. Brain Res. 334, 366-371.
23. KOCHANEK, P.M., MARION, D., ZHANG, W., et al. (1995). Severe cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. J. Neurotrauma 12, 1015-1025.
24. LEONARD, J.R., MARIS, D.O., and GRADY, M.S. (1994). Fluid percussion injury causes loss of forebrain choline acetyltransferase and nerve growth factor receptor immunoreactive cells in the rat. J. Neurotrauma 11, 379-392.
25. LEVEY, A., EDMUNDS, S., KOLIATSOS, V., WILEY, R., and HEILMAN, C. (1995). Expression of m1-m4 muscarinic acetylcholine receptor proteins on rat hippocampus and regulation by cholinergic innervation. J. Neurosci. 15, 4077-4092.
26. LEVIN, H.S., AMPARO, E., EISENBERT, H.M., et al. (1987). Magnetic resonance imaging and computerized tomography in relation to the neurobehavioral sequelae of mild and moderate head injuries. J. Neurosurg. 66, 706-713.
27. LEVIN, H.S., GROSSMAN, R.G., ROSE, J.E., and TEASDALE, G. (1979). Long-term neuropsychological outcome of close head injury. J. Neurosurg. 50, 412-422.
28. LYETH, B.G., JENKINS, L.W., HAMM, R.J., et al. (1990). Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res. 526, 249-258.
29. MARMAROU, A., ABD-ELFATTAH, M.A., VANDENBRINK, W., CAMPBELL, J., KITA, H., and DEMETRIADOU, K. (1994). A new model of diffuse brain injury in rats. Part I. Pathophysiology and biomechanics. J. Neurosurg. 80, 291-300.
30. MCINTOSH, T.K., VINK, R., YAMAKAMI, I., FERNYAK, S., SOARES, H., and FADEN, A.L. (1989). Traumatic brain injury in the rat: characterization of a midline fluid percussion model. J. Neurosci. 28, 233-244.
31. MOSER, E., MOSER, M., and ANDERSEN, P. (1993). Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesion. J. Neurosci. 13, 3916-3925.
32. MURDOCH, I., PERRY, I.K., COURT, J.A., GRAHAM, D.I., and DEWAR, D. (1998). Cortical cholinergic dysfunction after human head injury. J. Neurotrauma 15, 295-305.
33. NISSEN, M.J., KNOPMAN, D.S., and SCHACTER, D.L. (1987). Neurochemical dissociation of memory systems. Neurology 37, 789-794.
34. PALMER, A.M., MARION, D.W., BOTSCHELLER, M.L., SWEDLOW, P.E., STYREN, S.D., and DEKOSKY, S.T. (1993). Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J. Neurochem. 61, 2015-2024.
35. PARKER, S.A., and SERRATS, A.F. (1976). Memory recovery after traumatic coma. Acta Neurochir. 34, 71-77.
36. PIERCE, J.E.S., SMITH, D.H., TROJANOWSKI, J.Q., and MCINTOSH, T.K. (1998). Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats. Neuroscience 87, 359-369.
37. 2: diverse functional implications of differential synaptic localization. Life Sci. 60, 1031-1038.
38. SCHMIDT, R.H., and GRADY, M.S. (1995). Loss of forebrain cholinergic neurons following fluid-percussion injury: implications for cognitive impairment in closed head injury. J. Neurosurg. 83, 496-502.
39. 2 muscarinic receptor and mRNA and protein in rat. J. Neurotrauma.
40. SINSON, G., VODDI, M., and MCINTOSH, T.K. (1995). Nerve growth factor administration attenuates cognitive but not neurobehavioral motor dysfunction or hippocampal cell loss following fluid-percussion brain injury in rats. J. Neurosurg. 65, 2209-2216.
41. SMITH, D.H., OKIYAMA, K., THOMAS, M.J., CLAUSSEN, B., and MCINTOSH, T.K. (1991). Evaluation of memory dysfunction following experimental brain injury using the Morris water maze. J. Neurotrauma 8, 259-269.
42. SMITH, D.H., CHEN, X.H., PIERCE, J.E., et al. (1997). Progressive atrophy and neuron death for one year following brain trauma in the rat. J Neurotrauma 14, 715-727.
43. SQUIRE, L.R. (1985). Memory and hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol. Rev. 99, 195-231.
44. SQUIRE, L.R. (1987). Memory and Brain. Oxford University Press: New York.