RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood

Journal of Immunology

Volumn 166, Issue 1, 2001, Pages 377-386

  Girschick, H J ^a   Grammer, A C ^a   Nanki, T ^a   Mayo, M ^a   Lipsky, P E ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; IMMUNOGLOBULIN G; MESSENGER RNA;

ARTICLE; B LYMPHOCYTE; BLOOD; CELL SELECTION; CHILD; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE REARRANGEMENT; GERMINAL CENTER; HUMAN; HUMAN CELL; MEMORY CELL; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; THYMUS; TONSIL;

EID: 0035173472     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.1.377     Document Type: Article

References (56)

1. Somatic generation of antibody diversity
2. Downregulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement
3. RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination
4. Localization, interaction, and RNA binding properties of the V(D)J recombination-activation proteins RAG1 and RAG2
5. A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
6. The V(D)J recombination activating gene. RAG-1
7. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
8. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development
9. Receptor editing and commitment in B lymphocytes
10. Germinal centers
11. From the dark zone to the light
12. The germinal center: A crucible for lymphocyte selection
13. Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development
14. Germinal centers develop oligoclonally
15. The center of hypermutation
16. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
17. Analysis of somatic hypermutation in five B cell subsets of human tonsil
18. Maturation of the immune response in germinal centers
19. Germinal center development
20. Germinal centers: Form and function
21. Germinal centers: A second childhood for lymphocytes
22. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
23. Neoteny in lymphocytes: RAG1 and RAG2 expression germinal center B cells
24. V(D)J recombination in mature B cells: A mechanism for altering antibody responses
25. V(D)J recombinase activity in a subset of germinal center B lymphocytes
26. Expression and function of recombination activating genes in mature B cells
27. The reuse of B lymphocytes in germinal centers
28. Can receptor editing play an important role in normal B-cell development?
29. Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes
30. Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells
31. B lymphocytes may escape tolerance by revising their antigen receptors
32. Expression, regulation and function of B cells expressed CD154 in germinal centers
33. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization
34. RAG2: GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues
35. Immunoglobulin κ chain receptor editing in systemic lupus erythematosus
36. κ gene rearrangements in systemic lupus erythematosus
37. Analysis of heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
38. CD69 is expressed on platelets and mediates platelet activation and aggregation
39. T-cell receptor Vβ gene utilization in primary biliary cirrhosis
40. MHC class II antigens on lung epithelia of human fetuses and neonates: Ontogeny and expression in lungs with histologic evidence of infection
41. Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers
42. V(D)J recombination: Molecular biology and regulation
43. Cell cycle regulation of V(D)J recombination-activating protein RAG-2
44. V(D)J recombination and the cell cycle
45. Accessibility and the developmental regulation of V(D)J recombination
46. Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements of 5′ of RAG
47. Subepithelial B cells in the human palatine tonsil. II. Functional characterization
48. - bone marrow cells in vitro
49. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
50. Regulation of gene expression at early stages of B cell differentiation
51. Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines
52. Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines
53. In-vitro analyses of mechanisms of B-cell development
54. Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells
55. Isolation of genes negatively or positively co-expressed with human recombination activating gene 1 (RAG1) by differential display PCR
56. hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene (RAG1)